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Veterans with PTSD to test cannabis as a treatment for suicidal thoughts

NCT ID NCT06381180

Symptom relief Sponsor: Wayne State University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 1 time

Summary

This study looks at whether cannabis can help veterans who have PTSD and thoughts of suicide. About 500 veterans who have used cannabis in the past year will take part. Researchers will track changes in PTSD symptoms, mood, and suicide risk over time using interviews and questionnaires.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1/2

Runs two stages together: safety and dose first, then whether the treatment works.

Participants

About 500 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2025

Expected to finish

Dec 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

19 to 69 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * a healthy veteran who has served in a branch of the US armed forces * report using cannabis within the past year * currently meet DSM-5 criteria for PTSD and a score of 25 or greater on the CAPS-5 (the anchor, or index, trauma does not have to be related to military service) * between the ages of 19-69 years old * not seeking treatment for Cannabis Use Disorder * stable (i.e., under the care of a physician or therapist and not experiencing acute symptoms) on psychotropic medications and/or psychotherapy before the study begins (participants can be in treatment for PTSD) * agree to adhere to study procedures Exclusion Criteria: * pregnant, lactating, or heterosexually active women and not using medically approved birth control * current or past bipolar or psychotic disorder as determined using the SCID-5 * at immediate high risk for suicide based on the C-SSRS * current SUD other than Nicotine Use Disorder and Alcohol Use Disorder (mild or moderate) * allergies and/or other contradictions for using cannabis * any clinically significant medical problems * systolic/diastolic BP \>140/90 mmHg or systolic BP \<95 mmHg * elevated liver function tests * exhibit cognitive impairment (\<80 IQ) * enrolled in another clinical trial or have received any drug as part of a research study within 30 days of dosing * used a prescription medication (with the exception of birth control) within 14 days of study entry that in the opinion of the medically responsible investigator will interfere with the safety of the participant or the study results * unable to provide informed consent

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Conditions

The condition(s) this trial relates to.

cannabis dependence post-traumatic stress disorder Suicide

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cannabis use Marijuana Post traumatic stress disorder Suicide Veterans

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Wayne State University

    RECRUITING

    Detroit, Michigan, 48201, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.