TRAUMATIC BRAIN INJURY

This study is testing whether stem cells taken from a patient's own fat tissue can help the brain heal after a serious head injury. Researchers will give three infusions of these cells to 51 adults who have had a brain injury for more than six months, to see if it improves their …

This study is testing whether using real-time monitoring of harmful brain waves, called spreading depolarizations, can help doctors better guide treatment for patients with severe traumatic brain injury (TBI). About 72 patients who need emergency brain surgery will be enrolled. T…

This study aims to improve surgery for children with tight ankle muscles that limit their ability to walk properly. Researchers are testing if cutting a small, often-overlooked leg muscle (the plantaris) first, before the larger calf muscles, leads to better ankle movement and a …

This large study is testing if a simple muscle injection of a drug called tranexamic acid (TXA), given soon after a mild head injury, can help older adults. The goal is to see if it reduces brain bleeding, disability, death, and the later development of dementia. About 5000 adult…

This study is testing whether breathing pure oxygen in a pressurized chamber can help people recover from severe traumatic brain injuries. Researchers are enrolling 200 patients aged 16-65 who recently suffered severe brain trauma to find the safest and most effective pressure le…

This study is gathering more information about an already-approved medical stitch called STRATAFIX. Researchers want to see how well it works and how safe it is for closing wounds after brain or spine surgeries over the long term. They will track wound healing, check for infectio…

This study is testing if sildenafil citrate, the active ingredient in Viagra, can improve blood flow in the brain and help with long-term symptoms after a traumatic brain injury (TBI). Researchers will give 160 adults with chronic TBI either sildenafil or a placebo pill for four …

This study is testing a new therapy designed specifically for military veterans and service members who have both post-traumatic stress disorder (PTSD) and a traumatic brain injury. The treatment involves individual counseling sessions that focus on managing PTSD symptoms without…

This study is testing whether a non-invasive device called REAC can help the brain recover after a severe traumatic injury. Researchers will enroll 60 patients with diffuse axonal injury (a type of brain damage) and randomly assign them to receive either the real REAC treatment o…

This study is testing if a procedure that freezes specific nerves in the shoulder works as well as standard Botox injections for reducing pain and improving movement. It involves 50 adults with shoulder pain and stiffness (spasticity) caused by conditions like stroke, multiple sc…

This study is testing whether a safe, non-invasive light therapy can help older adults who have had a moderate to severe traumatic brain injury. Researchers want to see if shining light on the forehead improves blood flow to the brain and helps with thinking skills like planning …

This study aims to find out which of two common seizure-prevention medicines works better for adults with a serious traumatic brain injury. It will enroll 600 patients to see if one drug leads to fewer seizures and less agitation or behavioral problems than the other. The goal is…

This study is testing whether combining brain stimulation with memory training can improve thinking problems in veterans with lingering symptoms from mild traumatic brain injuries (mTBI). Participants will receive either real or fake brain stimulation along with cognitive exercis…

This study is testing whether adding a special egg yolk powder called Salovum to standard hospital care can help control dangerous swelling in the brain after a severe head injury. Twenty patients will be randomly assigned to receive either the active powder or a placebo powder f…

This study is testing a new method to objectively diagnose and monitor light sensitivity. Researchers will measure participants' facial muscle reactions, pupil responses, and other physical signals when exposed to light. The goal is to create a more reliable test for light sensit…

This study is testing a new forehead-mounted device called Crainio that aims to measure pressure inside the skull without surgery. It will be tested on 54 adults with traumatic brain injury who are already having standard, invasive pressure monitoring as part of their care. The g…

This study aims to develop a simple blood test to help doctors diagnose traumatic brain injuries (TBI) and predict patient recovery. It also seeks to use the test to monitor hospitalized patients for developing complications. The study will enroll 2000 adults who come to the emer…

This study is testing a portable device called SENSE to see if it can accurately detect bleeding in the brain after a traumatic head injury. Researchers will compare the SENSE Device's readings to the current standard test, a CT scan, in 150 adults. The goal is to see if this new…

This study is testing a new brain scanning technology to help personalize magnetic stimulation therapy for people with PTSD and traumatic brain injury. Researchers want to see if directly measuring brain activity with a special scanner can lead to more accurate treatment dosing t…

This study aims to develop a better test for diagnosing dizziness triggered by moving visual scenes, a common problem after concussion. Researchers will measure balance in 240 people—including those with post-concussion dizziness, other dizzy patients, and healthy volunteers—whil…

This study is testing a new device that aims to measure pressure inside the skull without needing surgery. Researchers will compare readings from the new, non-invasive device to those from the current surgical method in 581 patients with brain injuries or conditions. The goal is …

This study is testing whether a computer-based brain training program can improve memory, attention, and thinking skills in adults who have had a traumatic brain injury. Researchers will compare 25 adults using the specific BrainHQ training program against 25 adults using general…

This study is testing whether gentle vibrations applied to leg muscles can help improve movement and walking in people recovering from a stroke or similar brain injury. Researchers will compare real vibrations to fake (sham) vibrations in 56 participants to see if the treatment h…

This study is testing whether a special mobile app system can help people with chronic conditions like spinal cord injury or cerebral palsy better manage their daily self-care. The app sends reminders for tasks like medication, bladder routines, and skin checks, and lets users re…

This study is testing whether daily cannabidiol (CBD) pills can help reduce symptoms of Post-Traumatic Stress Disorder (PTSD). It will involve 120 adults with PTSD, half of whom also have a mild traumatic brain injury (TBI). Participants will take either a 400mg CBD dose, an 800m…

This study is testing a new rehabilitation method for adults recovering from traumatic brain injury (TBI). Researchers want to see if wearing special prism lenses that shift vision, combined with playing targeted computer games, can improve thinking skills like memory and attenti…

This study is testing two different telehealth programs to help veterans with mild to moderate traumatic brain injury sleep better. Researchers will compare a structured sleep coaching program (CBT-I) with a mindfulness-based approach (MBTI), both delivered in six video sessions.…

This study is testing whether breathing pure oxygen in a pressurized chamber can reduce long-term symptoms from traumatic brain injuries in military veterans and active service members. Researchers will compare the real oxygen treatment to a fake treatment (normal air) in 420 par…

This study tests whether combining gentle brain stimulation with computer-based thinking exercises can improve attention, memory, and decision-making in older adults who have had a traumatic brain injury (TBI). Researchers will compare two groups of veterans aged 65+ to see if th…

This study is testing whether gentle electrical stimulation of a neck nerve through the ear can help people with traumatic brain injury hear speech better in noisy environments. Researchers will compare two different stimulation approaches in 55 participants, including both peopl…

This study is testing a new rehabilitation device called the SSMD to see if it helps improve arm and hand movement in adults recovering from a stroke or traumatic brain injury. About 150 participants will be randomly assigned to use either the new SSMD device or a standard electr…

This study aims to see if Botox injections can help reduce painful sensitivity to light in people who have had a traumatic brain injury. Researchers will enroll 50 adults who have experienced light sensitivity for at least six months. The main goal is to measure changes in pain l…

This study is testing whether adding supervised aerobic exercise to a proven memory training technique helps people with moderate-to-severe traumatic brain injury (TBI) improve their ability to learn and remember new information. Researchers will enroll 60 adults with TBI-related…

This study is exploring whether hypnosis can be a helpful add-on therapy for people with neurological conditions like stroke, traumatic brain injury, or multiple sclerosis. It will test if hypnosis sessions are practical and acceptable for patients and if they show early signs of…

This study is testing whether a gentle, non-invasive brain stimulation technique can help people who have trouble finding words after a traumatic brain injury (TBI). Researchers will use a special cap to deliver a tiny electrical current to specific brain areas involved in memory…

This study is testing a brain implant system designed to help people with 'locked-in syndrome' communicate. Participants, who are fully conscious but severely paralyzed, will have a small device placed on their brain's surface. The goal is to see if they can learn to control a co…

This study is testing whether taking a dietary supplement called branched chain amino acids (BCAAs) can improve sleep quality and thinking skills in Veterans who have trouble sleeping. Researchers will recruit 300 Veterans and randomly assign them to take either the BCAA suppleme…

This small pilot study is testing whether gently stimulating a nerve in the wrist can help improve thinking skills like memory and attention in people who have recently suffered a traumatic brain injury. Researchers will enroll 30 patients to see if this non-invasive technique is…

This study is looking at whether a medical procedure called a bilateral cervical sympathetic block (BCSB) can help reduce trauma-related symptoms in Special Operations veterans. The procedure involves injecting medication near nerves in the neck to calm the body's stress response…

This study is testing whether a gentle, non-invasive electric stimulation to the brain can improve word-finding and memory problems in military veterans who have had a mild traumatic brain injury. Researchers will compare a real stimulation treatment to a fake one to see if it he…

This study aims to see if Xeomin injections work differently for preventing migraines in two groups of patients: those with a history of traumatic brain injury (TBI) and those with a history of anomalous health incidents (AHIs, sometimes called 'Havana Syndrome'). Researchers wil…

This study is testing whether a virtual wellness program can help people who have had a traumatic brain injury. The program combines mindfulness, exercise, and nutrition guidance to improve emotional well-being, physical activity, and overall quality of life. About 138 participan…

This study is testing whether listening to preferred music can help improve the level of consciousness in patients with severe brain injuries. It will involve 66 patients in early neurological rehabilitation who have disorders like coma or minimal consciousness. Patients will be …

This study is testing if a guided online sleep therapy program can help people with moderate to severe traumatic brain injuries who have insomnia. Researchers will compare the computer program against standard care in 80 participants across Colorado. All study activities, includi…

This study is testing a computer system designed to predict dangerous increases in brain pressure or drops in brain oxygen in patients with severe traumatic brain injury (TBI). The goal is to see if the system can accurately warn doctors 30 minutes to several hours before these h…

This study aims to understand how deep brain stimulation (DBS) surgery helps improve movement and speech in people with conditions like Parkinson's disease or essential tremor. Researchers will measure brain and muscle activity in 60 patients already scheduled for the standard DB…

This study is testing a new tool called the Pressure Relief Frequency Scale (PReFS). Researchers want to see if the tool is reliable and valid for creating personalized recommendations. The goal is to help clinicians advise wheelchair users on how often they should shift their we…

This study aims to understand if there is a connection between how a breathing machine is set and the severity of a patient's recent brain injury. Researchers will observe 19 adult patients who are on a ventilator due to a stroke, traumatic brain injury, or brain hemorrhage. They…

This study aims to understand how traumatic brain injuries affect the brain over three years. Researchers will compare MRI scans, blood samples, and thinking tests from 110 people with moderate-to-severe brain injuries against healthy volunteers. The goal is to measure how quickl…

This study is testing whether a gentle electrical brain stimulation technique can improve thinking skills like memory, attention, and decision-making in people with various mental health conditions and brain injuries. Researchers will recruit 600 adults with conditions including …

This study aims to better understand the real-world walking and navigation difficulties faced by people who have recovered from moderate to severe traumatic brain injuries. Researchers will compare how 40 participants (half with past brain injuries, half healthy) navigate complex…

This study aims to see if smart insoles can measure walking patterns as accurately as a specialized lab system. Researchers will compare measurements from pressure-sensitive insoles worn in shoes with those from an advanced treadmill lab in 30 people recovering from stroke or spi…

This small, early-stage study aims to understand how a single dose of ketamine affects brain pressure and oxygen levels in patients with severe traumatic brain injury. Researchers will monitor 10 critically ill patients who already have special brain monitors in place. The goal i…

This study aims to collect health information from thousands of people with conditions like Long COVID, ME/CFS, autoimmune diseases, and brain inflammation disorders over 10+ years. Participants will use a secure app to share symptoms, health history, and daily activity data. The…

This study aims to understand how a moderate traumatic brain injury (TBI) from many years ago might affect a person's balance and thinking skills as they get older. Researchers will compare 70 Veterans aged 50-75, some with a past TBI and some without, using balance and cognitive…

This study is testing whether a computer-based decision support system can help doctors better prevent dangerous blood clots (venous thromboembolism) in patients hospitalized with traumatic brain injury. The research will involve 15,000 adult patients across seven hospitals. The …

This study aims to understand the chemical changes in the body after a severe traumatic brain injury. Researchers will compare blood samples from 60 adults with severe brain injuries to samples from people with other serious injuries but no brain trauma. By analyzing these chemic…

This study aims to discover if unconscious brain injury patients who show brain activity in response to music and language during a simple bedside test are more likely to recover consciousness and function. Researchers will track 300 adults with traumatic brain injury or hemorrha…

This study aims to better understand a harmful process in the brain called 'cortical spreading depolarization' that can worsen damage after a severe traumatic brain injury (TBI). Researchers will place a small grid of electrodes on the surface of the brain in 10 patients who alre…

This study is testing whether breathing small, controlled amounts of carbon dioxide (CO2) can help move waste proteins out of the brain and into the blood. Researchers are enrolling 200 adults, both with and without a history of traumatic brain injury, to see if this process work…

This study aims to understand how traumatic brain injuries (TBI) in military service members and veterans might lead to thinking problems and vascular dementia. Researchers will follow 300 participants who had a TBI at least three years ago, collecting brain scans, blood tests, a…

This study is testing a new brain pressure monitor to see if it can better predict how patients recover from serious brain injuries. It will observe 250 adults with traumatic brain injury or stroke who need pressure monitoring as part of their standard care. The goal is to see if…

This study aims to better understand how deep brain stimulation (DBS) affects movement, speech, and swallowing in people with movement disorders. Researchers will recruit 60 patients who already have DBS implants to perform tasks with the stimulation turned on and off. The goal i…

This study aims to see if detailed pictures of the back of the eye (the retina) can reveal early signs of brain diseases like Alzheimer's and Parkinson's. Researchers will use special, non-invasive camera scans on 2000 people, both with and without these conditions. The goal is t…

This study aims to identify which factors best predict whether patients with severe brain injuries will regain consciousness during rehabilitation. Researchers will observe 130 patients in a coma or similar state, tracking their brain scans, electrical activity, and health status…