TRAUMATIC BRAIN INJURY

This study looks at two medications, levetiracetam and lacosamide, to see which one is better at preventing seizures in the first few days after a traumatic brain injury. Researchers will also check which drug causes fewer side effects like agitation or behavioral issues. The stu…

This study is testing whether a single IV infusion of stem cells taken from a patient's own belly fat can safely improve brain function and reduce inflammation in people who have had a traumatic brain injury at least 6 months ago. The trial will enroll 51 adults aged 18 to 55. Th…

This study tests if giving high-pressure oxygen (hyperbaric oxygen therapy) soon after a severe traumatic brain injury can improve recovery. It involves 200 people aged 16 to 65 with severe injuries. The goal is to find the best way to use this treatment to help patients regain f…

This study tests whether an early injection of tranexamic acid (TXA) can reduce brain bleeding, disability, and death in adults aged 50 and older who have had a mild head injury. Participants receive either TXA or a placebo within 3 hours of injury. The goal is to see if this sim…

This study looks at people who already have a deep brain stimulation (DBS) device for movement problems like tremor or stroke. Researchers will adjust the device's settings and then test how well participants can move their hands, speak, swallow, and make facial expressions. The …

This study tests whether a special egg yolk powder called Salovum can help people with severe traumatic brain injury. About 20 participants will receive either Salovum or a placebo powder alongside standard care. Researchers will measure brain pressure, oxygen levels, and inflamm…

This study tests a device called SSMD to see if it helps adults with arm weakness from stroke or traumatic brain injury. About 150 participants will get either SSMD therapy plus standard rehab or standard electrical stimulation plus rehab. The goal is to measure improvements in a…

This study tests whether baricitinib, a drug used for arthritis, can help people recover from moderate to severe traumatic brain injuries that involve bleeding. About 100 adults will receive the drug or a placebo within 24 hours of injury. The main goal is to see if it improves l…

This study tests whether sildenafil (the drug in Viagra) can improve blood flow in the brains of people who had a traumatic brain injury (TBI) at least 6 months ago. Researchers will give 160 adults different doses to find the safest and most effective one. The goal is to help th…

This study tests whether using a brain wave monitor to guide a step-by-step treatment plan can reduce harmful electrical events after severe traumatic brain injury. About 72 adults who need emergency brain surgery will be randomly assigned to standard care or the monitor-guided a…

This study tests a portable device called SENSE that aims to quickly detect bleeding in the brain after a traumatic injury. Researchers will enroll 150 adults aged 22 and older, including those with and without brain bleeding, plus healthy controls. The device's results will be c…

This study is testing a new device called Crainio that measures pressure inside the skull without needing surgery. It uses light sensors on the forehead to check for dangerous pressure levels in people with traumatic brain injury. The goal is to see if it can detect high pressure…

This study aims to create an objective way to diagnose and monitor light sensitivity by measuring facial expressions, pupil reactions, and nerve responses to light. Researchers will compare 120 people with and without light sensitivity (due to traumatic brain injury or migraine) …

This study aims to create a blood test that helps doctors quickly diagnose traumatic brain injury (TBI) and predict patient outcomes. Researchers will enroll 2,000 adults with suspected TBI and compare blood biomarkers to standard CT scans and clinical assessments. The goal is to…

This study looks at how moving visual patterns affect balance in people with dizziness, including those who have had a concussion. Researchers will compare patients with persistent dizziness to healthy volunteers to find better ways to diagnose visually induced dizziness. The goa…

This study is testing whether a non-invasive nerve stimulation on the wrist can help improve thinking and memory in people who have had a traumatic brain injury. The researchers will enroll 30 adults aged 18-64 who have thinking problems after their injury. Participants will rece…

This study tests whether a week-long course of accelerated brain stimulation (TMS) can quickly reduce PTSD symptoms. About 132 adults with PTSD, including some with traumatic brain injury, will receive either real or sham TMS over 5 days. The goal is to see if this condensed trea…

This study tests whether taking branched chain amino acids (BCAAs) twice a day for 21 days can improve sleep in people with traumatic brain injury. 300 veterans and community members with sleep problems will be randomly assigned to receive BCAAs or a placebo. The study will measu…

This study tests whether community health workers can help care partners of people with traumatic brain injury (TBI) manage the transition from hospital rehab to home. About 126 care partners will receive support via texts, calls, and check-ins. The goal is to improve care partne…

This study tests whether cannabidiol (CBD) can reduce PTSD symptoms and improve thinking in 120 adults with PTSD, half of whom also have a mild traumatic brain injury. Participants take either 400 mg, 800 mg of CBD, or a placebo daily for 8 weeks. The goal is to see if CBD helps …

This study tests if Botox can reduce light sensitivity (photophobia) in people who have had a traumatic brain injury. Researchers will measure changes in pain and visual function in 50 adults with chronic light sensitivity. The goal is to find a new treatment to ease this common …

This study is testing a noninvasive treatment called REAC therapy in 60 people who have suffered a severe traumatic brain injury called diffuse axonal injury. The treatment uses gentle electrical signals to try to rebalance brain activity. Researchers will measure changes in brai…

This study explores whether hypnosis can help people with stroke, traumatic brain injury, or multiple sclerosis improve their attention and reduce fatigue. Researchers will use EEG to monitor brain activity during hypnosis sessions. The goal is to see if this approach is practica…

This study tests a virtual program that teaches mindfulness, exercise, and nutrition to people who have had a traumatic brain injury (TBI) at least one year ago. About 138 participants will be randomly assigned to start the program right away or after a delay. The goal is to see …

This study looks at a special stitch (STRATAFIX) already approved for closing wounds after brain or spine surgery. Researchers want to see if it helps wounds heal better and with fewer problems. About 160 adults having these surgeries will take part. The goal is to improve recove…

This study tests whether a low-level electric current applied to a specific brain area can improve verbal retrieval (word-finding) in military veterans who have had a mild traumatic brain injury. Researchers will compare changes in memory tests over several months between those r…

This study tests whether adding aerobic exercise to a memory training program helps people with moderate to severe traumatic brain injury learn and remember better. Sixty adults with memory problems will be assigned to either memory training plus exercise or memory training plus …

This study tests whether listening to preferred music can improve the level of consciousness in patients with severe brain injuries, such as traumatic brain injury or disorders of consciousness. Researchers will measure changes in consciousness using a standard scale and brain sc…

This study tests whether a gentle, non-invasive brain stimulation technique called HD-tDCS can improve word-finding difficulties in people who had a traumatic brain injury at least one year ago. About 24 adults will receive either real or fake stimulation during word and memory t…

This study looks at whether a procedure called a cervical sympathetic block can reduce PTSD, anxiety, and other trauma-related symptoms in Special Operations Veterans. About 75 veterans will receive the block alone or with added therapy. The goal is to see if this approach provid…

This study tests whether using special prismatic lenses, combined with brain-training games, can improve thinking and behavior in people recovering from a traumatic brain injury. Fifty adults who had a brain injury within the past 90 days will be randomly assigned to receive eith…

This study tests whether adding gentle brain stimulation (rTMS or HD-tDCS) to cognitive training can improve memory, attention, and quality of life in veterans with mild traumatic brain injury. About 108 participants will receive 16 sessions of either real or sham stimulation whi…

This study tests a non-invasive light therapy called transcranial photobiomodulation (tPBM) in 70 older adults (ages 55-85) who had a moderate to severe traumatic brain injury 1-2 years ago. The goal is to see if the light can increase blood flow to the brain and improve thinking…

This study tests a procedure called cryoneurolysis, which uses cold to freeze specific nerves in the shoulder, to see if it relieves pain and improves movement in people with spasticity (muscle tightness) after stroke, brain injury, or multiple sclerosis. It compares the freezing…

This study tests a nurse-guided brief behavioral treatment for insomnia in people recovering from traumatic brain injury (TBI). About 93 participants will receive either in-person or mobile-delivered therapy to improve sleep, mood, and thinking skills. The goal is to find a simpl…

This study tests whether a gentle, non-invasive brain stimulation (tDCS) combined with computer-based brain games can improve attention, memory, and decision-making in veterans aged 65 and older who have had a mild traumatic brain injury. Participants will do brain-training exerc…

This study tests if breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) can reduce long-term symptoms like headaches, memory problems, and mood changes in veterans with mild to moderate traumatic brain injury. About 420 veterans and active military members …

This study looks at whether Xeomin (a Botox-like drug) can prevent migraines in 60 adults who have either a traumatic brain injury or an anomalous health incident (like those reported by diplomats). Participants get Xeomin injections and report their headache pain and frequency o…

This study is testing whether a mobile health app can help people with chronic conditions like spinal cord injury, cerebral palsy, spina bifida, or traumatic brain injury better manage their health and improve their quality of life. About 160 participants aged 12 and older who li…

This study tests whether a special liquid diet (semi-elemental nutrition) can reduce stomach and bowel problems like vomiting, diarrhea, and bloating in people with severe traumatic brain injury. About 100 adults will be randomly assigned to receive either this special diet or st…

This study tests a portable virtual reality system called VERVE that uses eye-tracking to deliver automated eye exercises. It aims to improve convergence insufficiency—a common vision problem after mild traumatic brain injury—in 100 veterans. Participants will be divided into act…

This study tests two types of talk therapy—cognitive behavioral therapy (CBT) and mindfulness-based therapy—to see which works better for treating insomnia and related depression in people who have had a mild to moderate traumatic brain injury (TBI) and also have post-traumatic s…

This study tests a guided online program for insomnia in 80 adults who had a moderate to severe traumatic brain injury at least one year ago. The program is a computerized version of cognitive behavioral therapy for insomnia (cCBT-I) and is compared to usual care. The goal is to …

This study tests a non-trauma psychotherapy for military veterans and service members who have both PTSD and a mild or moderate traumatic brain injury (TBI). The treatment involves individual talk therapy sessions to help manage PTSD symptoms. The study will enroll 30 participant…

This study uses special eye scans to look for early signs of brain diseases like Alzheimer's, Parkinson's, and multiple sclerosis. Researchers will examine the tiny blood vessels and layers in the eyes of 2,000 adults—both healthy and with brain conditions—to see if eye changes c…

This study aims to see if a new technology combining brain stimulation (TMS) with brain imaging (fNIRS) can directly measure brain activity to personalize treatment dosing for people with PTSD, with or without mild traumatic brain injury. About 60 adults aged 18-70 who are eligib…

This study explores whether breathing small amounts of carbon dioxide (CO2) can safely increase the movement of proteins from the brain into the blood, which may indicate better waste clearance. Researchers will compare 200 adults with and without a history of traumatic brain inj…

This study looks at how deep brain stimulation (DBS) changes movement in people with conditions like Parkinson's disease or essential tremor. About 60 people already scheduled for DBS surgery will have temporary brain recordings during their procedure. The goal is to understand t…

This study tests a noninvasive nerve stimulation device to see if it can improve how people with traumatic brain injury understand speech in noisy environments. Researchers will compare brain responses and speech test scores between a treatment and a placebo. The goal is to under…

This study tests a computer program that predicts when dangerous brain pressure or low oxygen levels will occur in people with severe traumatic brain injury. The goal is to give doctors a warning so they can treat the problem before permanent damage happens. About 120 adults will…

This study checks if a pressure-sensitive insole (Ceriter Stride One) can accurately measure walking patterns in people recovering from stroke, brain injury, or spinal cord injury. About 30 participants will wear the insoles while walking on a high-tech treadmill (GRAIL) before a…

This study looks at a small leg muscle called the plantaris and its role in treating tight ankles (ankle equinus) in children aged 4-17. About 42 kids having surgery for this condition will have the plantaris and larger calf muscles lengthened in a random order. The goal is to se…

This study is testing a computer tool that helps doctors follow the best guidelines for preventing blood clots in adults with traumatic brain injury. About 15,000 patients across 7 hospitals will take part. The goal is to see if the tool improves how often patients get the right …

This study is testing whether a new digital test battery called Mindmore Distance can accurately assess thinking and memory skills in people with neurological conditions like traumatic brain injury, stroke, multiple sclerosis, Parkinson's disease, epilepsy, or brain tumors. Resea…

This study looks at how past traumatic brain injuries (TBI) may affect thinking skills and blood vessel health in military personnel and veterans. Researchers will measure substances in the blood linked to blood vessel damage, inflammation, and brain cell loss. They aim to find p…

This study tests whether a computer program called BrainHQ can help improve memory and attention in adults who have had a traumatic brain injury (TBI). About 150 adults with mild, moderate, or severe TBI will either use BrainHQ or play regular brain games. Researchers will compar…

This study looks at how people with moderate to severe traumatic brain injury (TBI) walk and navigate in realistic virtual environments, like streets with other people. Researchers want to understand the specific difficulties these individuals face in everyday situations. The stu…

This study looks at how a traumatic brain injury (TBI) can lead to heart problems, a condition called cerebrocardiac syndrome. Researchers will use MRI scans to examine the brains of 90 people with mild or moderate TBI and check their heart health with ECGs, echocardiograms, and …

This study follows 130 patients with severe brain injuries (from stroke, trauma, or lack of oxygen) who are in a coma or minimally conscious state. Researchers will use brain scans, electrical tests, and regular check-ups to find clues that predict if and when a patient might reg…

This study involves 4,000 emergency room patients who take blood thinners and have a head injury. Researchers want to develop a checklist to determine who can safely avoid a CT scan of the brain. The goal is to reduce unnecessary scans while still catching serious injuries.

This study looks at whether unconscious patients with brain injuries show brain activity when they hear music or language. Researchers use a simple bedside EEG test to measure this. The goal is to see if this brain activity can predict who will wake up and recover better. The stu…

This study tests whether gentle muscle vibrations can help the brain form new connections after a stroke or traumatic brain injury. Researchers will measure brain and nerve activity in 56 participants before, during, and after a 5-week vibration treatment. The goal is to understa…

This study collects health information from up to 10,000 people with conditions like Long COVID, ME/CFS, and autoimmune diseases. Participants use a phone app to share symptoms, wearables data, and lifestyle details. The goal is to help researchers better understand these illness…

This study explores whether a brain-computer interface (BCI) can help people with motor disorders, like spinal cord injury or stroke, control assistive devices just by thinking about moving. Researchers will use electrical stimulation to train the brain and improve BCI accuracy. …

This study places special electrodes on the brain surface of 10 people who need surgery for severe traumatic brain injury. The goal is to record brain activity and find where abnormal electrical waves called cortical spreading depolarizations begin. Researchers will also compare …

This study is testing whether a non-invasive brain stimulation technique called tDCS can improve executive functions—like memory, attention, and decision-making—in people with various neuropsychiatric conditions. Researchers will enroll 600 adults with diagnoses such as traumatic…

This study looks at Veterans aged 50-75 who had a moderate traumatic brain injury (TBI) at least 15 years ago. Researchers want to see if these individuals have hidden problems with balance and thinking, even if they feel fine. The goal is to learn how to design future programs t…

This study is testing a new device that measures pressure around the brain from outside the head, avoiding the need for risky surgery. Researchers will collect data from 581 patients who already have standard surgical monitors, to help develop a safer, non-invasive alternative. T…

This study looks at how a single dose of ketamine affects brain pressure and oxygen levels in 10 adults with severe traumatic brain injury. Participants must already have monitors in place to measure these brain signals. The goal is to gather early safety data, not to treat the i…

This study is testing a new monitor that continuously measures pressure inside the skull in patients with serious brain injuries like traumatic brain injury or stroke. The goal is to see if the pressure readings can help doctors predict which patients will recover well and which …

This study looks at how sleep problems—like trouble falling asleep or waking up often—affect people who have had a traumatic brain injury (TBI). Researchers will track sleep using a movement monitor and ask about mental health and daily activities. The goal is to understand these…

This study is testing a new questionnaire called the Pressure Relief Frequency Scale (PReFS) to see if it can help wheelchair users with neurologic disorders (like spinal cord injury, stroke, or traumatic brain injury) know how often they should shift their weight to prevent pres…

This study looks at chemical markers in the blood of people with severe traumatic brain injury (TBI) compared to those with broken bones but no brain injury. Researchers aim to find differences that could help doctors better understand injury severity and predict recovery. The st…

This study tests a brain implant that lets people with locked-in syndrome control a computer using their thoughts. Two participants will have electrodes placed on their brain to try typing or selecting words. The goal is to see if they can use the system at home on their own.

This study follows 110 people with moderate to severe traumatic brain injury (TBI) for up to 3 years to see how their brains change compared to healthy individuals. Participants will give blood samples, have MRI scans, and take thinking and memory tests. The goal is to measure ho…

This observational study looks at whether the settings on a breathing machine (like pressure and power) are linked to how severe a person's brain injury is. It includes 19 adults with brain injuries from stroke, trauma, or bleeding who need a breathing machine. The goal is to see…