TRAUMATIC BRAIN INJURY

This study tests whether a sodium lactate infusion is safe for people with severe traumatic brain injury in the intensive care unit. Researchers will monitor for side effects and measure biological markers. The trial involves 264 adults aged 18-80 with a low score on a brain func…

This study tests whether a hormone called hCG (Ovidrel) can help men aged 18-65 recover thinking skills and daily function after a moderate to severe traumatic brain injury. Participants receive either the hormone or a placebo twice a week for 24 weeks. The main goal is to check …

This study tests whether using a personalized 'optimal' blood pressure target for each patient with severe traumatic brain injury can reduce brain damage compared to standard one-size-fits-all targets. About 60 adults in the ICU will be randomly assigned to either personalized or…

This study tests whether a 5-day course of the steroid methylprednisolone can help adults with moderate to severe traumatic brain injury recover better. About 520 participants will receive either the drug or a placebo, added to standard care. Researchers will check brain function…

This study tests a wearable robot that helps people with traumatic brain injury (TBI) relearn movement while still in bed, even if they are paralyzed. The robot guides the ankle through exercises to improve motor and sensory function. The trial involves 100 adults aged 30-85 with…

This study looks at whether three ultrasound techniques can accurately measure pressure inside the skull after a head injury, without needing surgery. Researchers will compare these non-invasive methods to the standard invasive monitor in 64 adults with traumatic brain injury. If…

This study tests a small, portable device that uses near-infrared light to find brain bleeds in people with traumatic brain injury. The goal is to see if it works as well as a CT scan, especially in places like battlefields or rural areas where CT machines aren't available. About…

This early-stage study tests whether a non-invasive device that stimulates the vagus nerve through the ear is safe and practical for people with moderate to severe traumatic brain injury. Sixteen adults in the ICU will receive either real or sham stimulation. Researchers will tra…

This study tests a new virtual reality (VR) walking program for people with traumatic brain injury or stroke. Participants will use a VR headset while walking overground, and their progress will be tracked with a Fitbit and walking tests. The goal is to see if this immersive ther…

This study tests a stepped-care version of Parent-Child Interaction Therapy (PCIT) for children aged 2 to 7 who have a mild to moderate traumatic brain injury (TBI) and behavior problems. Researchers will work with 20 parent-child pairs to see if the therapy reduces disruptive be…

This study tests whether an interactive website called Man Therapy can help reduce problematic anger in male military service members. About 226 participants who screen positive for anger issues will either use the program right away or wait and receive it later. The goal is to s…

This early study tests whether a low-strength magnetic therapy device, used at home, is safe and practical for people with cognitive issues from brain injury, Long COVID, or Alzheimer's. About 30 adults will use the device regularly and complete computer-based thinking tests. The…

This study tests whether adding a mild electrical stimulation to the spinal cord during walking exercises helps people with traumatic brain injury (TBI) walk better and improve balance. Thirty adults with weakness on one side of the body will be enrolled. The goal is to see if th…

This pilot study tests whether a non-invasive technique called transcranial alternating current stimulation (tACS) can improve working memory in 30 adults with mild cognitive impairment or traumatic brain injury. Participants will receive gentle electrical stimulation to the brai…

This study tests if using augmented reality (AR) games can help people with brain injuries stick with their rehab therapy. Researchers will have 30 adults try the GlenXRose AR program alongside standard care to see if it improves how often they practice and their overall recovery…

This study tests whether a safe, noninvasive brain stimulation technique called tDCS, combined with thinking exercises, can improve attention, memory, and mental flexibility in people who had a traumatic brain injury at least two years ago. About 20 adults will receive personaliz…

This study looks at a program called TBI-RECOVER that screens people in substance use treatment for brain injuries and provides special support. Researchers want to see if this helps patients stay in treatment longer and feel better. About 900 patients and their providers will ta…

This study looks at whether playing special music to people in a coma after a severe brain injury can help them recover thinking skills. About 35 adults will listen to music through headphones. Their progress will be compared to similar patients from the past who did not get musi…

This study looks at whether giving different amounts of protein early on can help people with serious brain injuries or strokes recover better. About 216 adults in the ICU will be split into three groups, each receiving a different protein dose. Researchers will check their consc…

This study looks at how a device that sends small electrical signals to the leg muscles affects walking in people with stroke, traumatic brain injury, or multiple sclerosis. Researchers will measure walking speed, step length, and balance in 90 adults who have trouble lifting the…

This study follows 10 people aged 6 to 75 with chronic traumatic brain injury who choose to get MUSE stem cell therapy outside the U.S. Researchers will watch for side effects and track changes in brain function, quality of life, and daily activities over 12 months. No treatment …

This study looks at how air moves in the lungs of brain-injured patients when doctors are trying to remove their breathing tube. Researchers will use a special imaging belt (electrical impedance tomography) to see if certain lung ventilation patterns can predict whether the tube …

This study aims to find out which of two strategies better helps people with traumatic brain injury feel more in control and involved in their healthcare. About 142 adults who are at least one year post-injury and see a brain injury doctor will take part. Participants will comple…

This study looks at 100 people with moderate to severe traumatic brain injury to see if special MRI scans can help predict how well they will recover after one year. Participants get an extra MRI scan, but no change to their treatment. The goal is to find better ways to understan…

This study tests whether gentle, non-invasive brain stimulation can help people with traumatic brain injury remember locations better. About 25 adults with TBI will use a virtual reality game to find objects while their brain is stimulated or not. Researchers will also measure br…

This study looks at whether a steroid called dexamethasone can help reduce brain swelling in people who have had a traumatic brain injury. Researchers will follow 280 adults aged 18 to 70 who already receive this treatment as part of their care, and compare them to similar patien…

This study aims to see if a device that combines magnetic brain stimulation with EEG can detect differences in brain activity between people with traumatic brain injury (TBI) and healthy individuals. Researchers will test 215 participants, including those with recent or past TBI.…