TRAUMATIC BRAIN INJURY

This study is testing whether adding a 5-day course of the steroid methylprednisolone to standard hospital care can help adults recover better from a moderate to severe traumatic brain injury. Researchers will compare the steroid against a placebo in 520 patients to see if it imp…

This study is testing a new support program called TBI-RECOVER for people with both a brain injury and a substance use disorder. It will train therapists to screen for brain injuries and adjust their therapy methods to help patients stay in treatment longer. The goal is to see if…

This study tests a new personalized approach to managing blood pressure in patients with severe traumatic brain injury. Currently, all patients receive the same fixed blood pressure targets in intensive care. Researchers will use new technology to determine the 'optimal' blood pr…

This study is testing whether a mild electrical stimulation applied to the spine during walking exercises can improve mobility more than exercises alone for people with weakness on one side of their body after a traumatic brain injury. Researchers will compare walking speed, bala…

This study is testing whether giving sodium lactate through an IV can help the brain heal after a severe traumatic injury. It will involve 264 patients in intensive care units across 10 medical centers. The research aims to find the safest, most effective dose and see if this tre…

This study aims to find out if giving the steroid dexamethasone to adults with traumatic brain injury helps reduce dangerous brain swelling that can occur in the second week after the injury. Researchers will compare recovery in about 280 patients who receive the steroid treatmen…

This study aims to find the best amount of protein to give to critically ill brain injury and stroke patients through a feeding tube. Researchers will compare three different protein doses to see which one most helps patients regain consciousness, survive, and leave the hospital …

This study is testing a new, portable scanner designed to quickly detect dangerous brain bleeds (intracranial hemorrhage) in people with head injuries. The goal is to provide a fast, accurate diagnostic tool for use in emergency settings like battlefields or remote areas where tr…

This study is testing a new type of brain scan to see if it can better detect and measure the effects of a traumatic brain injury (TBI). Researchers will compare brain activity in adults who have had a head injury to healthy adults without an injury. The goal is to see if this sc…

This study aims to find a safer way to measure dangerous pressure inside the skull after a head injury. Researchers will test if a simple bedside ultrasound scan on the eye and head is as accurate as the current method, which requires surgery to place a monitor. The goal is to pr…

This study is testing a wearable robot designed to help people who have recently had a stroke or traumatic brain injury (TBI) regain movement in their legs. The robot guides patients through stretching, sensory stimulation, and movement games, even if they are currently paralyzed…

This study is testing whether a gentle, non-invasive brain stimulation technique can help improve thinking skills in people with long-term effects from a traumatic brain injury (TBI). Researchers will combine this stimulation with personalized cognitive training therapy. The goal…

This study is testing whether augmented reality games can make rehabilitation more engaging for people recovering from brain injuries like stroke or trauma. Researchers want to see if turning therapy exercises into fun games helps patients stick with their treatment plans better …

This study is testing a new virtual reality (VR) program to help people with traumatic brain injury or stroke improve their walking. It compares immersive VR therapy where patients walk on the ground to a standard treadmill-based VR system. The goal is to see if the immersive VR …

This study aims to better understand how the lungs work in brain-injured patients who are trying to stop using a ventilator. Researchers will use a special belt with sensors to take pictures of how air moves in different parts of the lungs. They hope to find patterns that can pre…

This study aims to gather information on the safety and potential effects of an experimental stem cell therapy (called MUSE cells) for people with chronic traumatic brain injury. It will follow 10 participants, aged 6 to 75, who have chosen to receive this treatment at clinics ou…

This study aims to understand if gently stimulating a deep part of the brain can help improve navigation and memory problems in people who have had a traumatic brain injury. Participants will play a virtual reality game to test their memory while receiving either real or placebo …