TRAUMATIC BRAIN INJURY

This study tests a program called BETTER, designed to help adults with traumatic brain injury and their families after they leave the hospital. The program provides education, training, and therapy to improve recovery and quality of life. About 500 participants will be randomly a…

This study tests a program called the Reentry Continuum for Brain Injury (RCBI) for prisoners with traumatic brain injury (TBI) who are about to be released. The goal is to help them avoid returning to prison and reduce violent behavior. 102 participants will be randomly assigned…

This study tests a weight-loss program designed for people with traumatic brain injury (TBI). About 57 adults with TBI and a BMI of 25 or higher will join a group lifestyle program or a support group. Researchers will track weight, physical activity, and other health measures for…

This study tests whether certain FDA-approved drugs, used off-label, can improve recovery after a traumatic brain injury (TBI). Researchers will compare recovery in 672 adults who receive the experimental drug versus a placebo. The goal is to see if these drugs reduce brain damag…

This study aims to make a proven weight-loss program more accessible for people with traumatic brain injury (TBI) by delivering it via telehealth. About 85 adults with moderate to severe TBI and a BMI of 25 or higher will participate. The program focuses on healthy eating and phy…

This study tests whether an FDA-approved drug, used off-label, can improve recovery in adults with severe traumatic brain injury (TBI). 26 participants will receive either the drug or a placebo within 24 hours of injury. The main goal is to see if the drug improves daily function…

This study tests whether a non-invasive brain stimulation technique called tDCS can improve thinking skills and daily function in veterans who had a mild traumatic brain injury more than a year ago. Forty-one participants will receive either real tDCS or a sham (fake) version whi…

This study tests a new type of magnetic brain stimulation in 15 adults with ongoing symptoms after a mild traumatic brain injury. Participants receive 30 short treatment sessions and undergo MRI scans to see if the therapy reduces symptoms and improves daily functioning. The goal…

This pilot study tests whether virtual reality treadmill training can improve balance, mobility, and reduce fear of falls in people with traumatic brain injury. Twenty adults aged 18 to 90 who have had a TBI for at least a year will be randomly assigned to either VR treadmill tra…

This study tests whether morning bright light therapy can improve sleep in 300 veterans who have had a traumatic brain injury. Participants use a light box at home each morning. Researchers also check if better sleep leads to improvements in thinking, mood, and quality of life, a…

This study tests whether a daily dose of pregnenolone, a natural hormone, can improve mental and physical health in veterans who have had a traumatic brain injury (TBI) for years. About 108 veterans from recent conflicts will take either the hormone or a placebo for 8 weeks. Rese…

This study is testing a set of five virtual reality games (exergames) in the metaverse designed to improve cognitive skills like memory, attention, and problem-solving in people with neurological disorders such as multiple sclerosis, Parkinson's disease, stroke, and traumatic bra…

This study aimed to use high-frequency brain signals to better understand how the brain works in people with epilepsy, migraines, and other conditions. Researchers planned to create a database of these signals to improve diagnosis and treatment. However, the study was withdrawn b…

This study follows 1,500 adults aged 65 and older who have had a traumatic brain injury (TBI), along with similar healthy participants, for 12 months. Researchers will use brain scans, blood tests, and health history to better understand how recovery happens and to create tools t…

This study looks at why some children have poor recovery after a severe head injury. The researchers are using special monitors to track oxygen and chemical changes in the brain, which are not routinely used in children. By collecting this information from 50 children aged 3 to 1…

This study was designed to test a program that would help caregivers of people with traumatic brain injury improve their problem-solving skills. It was withdrawn before any participants were enrolled, so no results are available.

This study watches people with brain or nerve conditions like traumatic brain injury, cerebral palsy, multiple sclerosis, Alzheimer's, Parkinson's, stroke, or autism who choose to get intranasal stem cell or exosome therapy as part of their regular care. Researchers track safety …

This study looks at whether a computer program can help doctors set breathing machines (ventilators) in a way that protects both the lungs and the brain. About 728 adults with serious brain injuries from strokes, bleeding, or trauma took part. The goal was to see if the program c…

This study tests a new therapy designed to help veterans with traumatic brain injury improve how they tell stories and have conversations. The therapy targets both the content and organization of stories. Researchers are checking if the treatment is practical and acceptable to pa…

This study follows 300 people who had a traumatic brain injury (TBI) to better understand how epilepsy can develop months or years later. Researchers will check participants' recovery and any seizure-like events over time, using interviews and blood tests. The goal is to improve …

This study is testing a remote therapy program called ICARE for people who have had a traumatic brain injury (TBI) at least one year ago. The program aims to help them and their care partners better recognize and respond to others' emotions. Researchers are checking if the progra…

This study looks at how a serious injury or burn that requires ICU care can affect thinking and memory years later. Researchers are following 432 adults to measure long-term cognitive problems and understand how inflammation in the body might play a role. The goal is to learn why…