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Can a brain scan predict epilepsy after a head injury?

NCT ID NCT03999164

Knowledge-focused Sponsor: University of California, Davis Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 15, 2026 · Updated 2 times

Summary

This study looks at 30 people who have had a moderate to severe traumatic brain injury. Researchers use special PET scans to measure inflammation in the brain at two weeks and two months after the injury. The goal is to see if the amount of inflammation is linked to a higher risk of developing epilepsy later on.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2020

Expected to finish

Nov 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 100 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Acute Traumatic Brain Injury (TBI) * Age 18-100 are eligible * Glasgow Coma Scale (GCS) 3-13 without continuous sedation at time of enrollment * Ability to enroll within 72 hours of injury * Hemorrhagic contusional injuries to frontal and/or temporal lobes. * Polytrauma including long bone fractures, blunt trauma, abdominal trauma or similar will be allowed * Penetrating TBI if continuous electroencephalography (cEEG) is feasible and survival for 2 years is feasible, recognizing that MRI may not be feasible with some forms of penetrating trauma Exclusion Criteria: * Low-affinity TSPO binding profile * Ages 17 years or younger * Patients with diffuse axonal injury in the absence of hemorrhagic contusions or skull fracture, and isolated epidural hemorrhages that improve after evacuation * No planned continuous EEG monitoring during injury day 1-7 * Inability to undergo MRI at 14 days (± 4 days) due to bullet, metal implant, or pacemaker * Pregnancy * Pre-existing Neurodegenerative Disorders * Pre-existing epilepsy/seizure disorder * Pre-existing dementia * Isolated anoxic brain injury * Incarceration present or pending * Devastating cervical spine injury

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Conditions

The condition(s) this trial relates to.

Brain Injuries, Traumatic Neuroinflammatory Diseases traumatic brain injury post-traumatic epilepsy prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Epilepsy, post-traumatic

Contacts and locations

Locations

  • University of California, Davis

    Sacramento, California, 95817, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.