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Machine learning may forecast brain decline after head injury

NCT ID NCT05084352

Knowledge-focused Sponsor: University of Maryland, Baltimore Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 04, 2026 · Last updated Sep 04, 2026

Summary

This study tests whether a computer algorithm can predict neurological decline in people who arrive at the hospital within 6 hours of a traumatic brain injury. Researchers will collect vital sign data and use machine learning to see if it can forecast worsening brain function, such as a drop in consciousness or the need for emergency intervention. The study includes 1,200 adults with traumatic brain injury. If successful, this approach could help doctors act faster to prevent further damage.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Predictive algorithm using vital sign data and machine learning
What this could lead to
If the algorithm works, doctors could use it to spot early signs of worsening brain injury and intervene sooner, potentially saving lives and reducing long-term damage.
What could go wrong
The algorithm is still being tested for accuracy. It may not work reliably across all patients, and the study does not test a treatment, so it will not directly change outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

1,200 people

The number who actually took part.

Started

Mar 2021

Finished

Aug 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult TBI patients

Ages

18 to 79 years

Sex

Anyone

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Arrival to the hospital within 6 hours of injury * Age \>= 18 years old * Patients with traumatic brain injury(TBI). TBI is defined as any alteration or loss of consciousness with or without positive head C.T findings. Exclusion Criteria: * Deemed to have a non-survivable TBI * Brain dead on arrival * Active substance abuse for opiates and cocaine as noted by admission toxicology screen. * Any thoracic or abdominal injury resulting in open surgical intervention * Pregnancy * Prisoners * Active military * Non - English speaking (due to necessity for consent in aims 2 and 3) * Age \> 89 years

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Conditions

The condition(s) this trial relates to.

Brain Injuries, Traumatic traumatic brain injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Traumatic brain injury

Contacts and locations

Locations

  • University of Maryland Medical Center

    Baltimore, Maryland, 21210, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.