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New study aims to better predict recovery after head injury in seniors

NCT ID NCT07296783

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study follows 1,500 older adults (65+) who come to the emergency department after a traumatic brain injury, along with matched controls. Researchers will track their recovery over 12 months using brain scans, blood tests, and health assessments. The goal is to develop age-appropriate tools to diagnose TBI and predict long-term outcomes in seniors.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to better tools for diagnosing and predicting recovery after head injury in older adults.
What could go wrong
This is an observational study, not testing a treatment. Results may not apply to all older adults or lead to immediate changes in care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 1,500 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2019

Expected to finish

Jan 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Participants are those with and without TBI, along with study partners.

Ages

65 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

TRACK-GERI/VA TBI PATIENT INCLUSION/EXCLUSION CRITERIA Inclusion Criteria: 1. Age 65 years and older, no upper age limit 2. Reliable report or physical evidence of head trauma 3. Injury occurred \<72 hours ago (within 14 days of injury for TRACK-VA TBI patients) 4. Acute brain CT for clinical use 5. Fluency in English/Chinese (UCSF only) 6. Ability to obtain informed consent from subject or legally authorized representative 7. Ability to be co-enrolled with a study partner who meets Study Partner enrollment criteria Exclusion Criteria: 1. Significant polytrauma that would interfere with follow-up and outcome assessment 2. Prisoners or patients in custody 3. Patients on psychiatric hold (e.g. 5150, 5250) 4. Low likelihood follow-up (participant or family is indicating a low interest, homelessness, out of state/country) 5. Current participation in an interventional trial 6. Penetrating TBI 7. Spinal cord injury with ASIA score of C or worse 8. Acute disabling neurological injury (e.g. acute stroke, cardiac arrest concurrent with head trauma presentation) TRACK-GERI/VA STUDY PARTNERS OF TBI PATIENTS INCLUSION/EXCLUSION CRITERIA Inclusion Criteria: 1. Age 18 years or older 2. Either designated by the patient, presents with patient to the Emergency Department, is listed in the patient's medical chart as an alternate/emergency contact, or is the patient's case manager/social worker, and knows the patient well enough to comment on the patient's health and functional status (e.g. may be family member, friend, caregiver, case manager, etc). 3. Ability to read, write, and speak English/Chinese (UCSF only) 4. Ability to provide informed consent for self Exclusion Criteria: 1. Pre-existing and major disabling medical, psychiatric, or other neurological disease (e.g. dementia) that interferes with ability to provide evaluation of patient's health and functional status. 2. Prisoners or patients in custody 3. Patients on psychiatric hold (e.g. 5150, 5250) TRACK-GERI/VA CONTROL SUBJECT INCLUSION/EXCLUSION CRITERIA Inclusion Criteria: 1. Age 65 years or older, no upper age limit 2. Visual acuity/hearing adequate for testing 3. Fluency in English/Chinese (UCSF only) 4. Ability to obtain informed consent from subject or legally authorized representative 5. Ability to be co-enrolled with a study partner who meets study partner enrollment criteria (see control study partner enrollment criteria) 6. For TRACK-VA patients only: Presentation to SFVAMC ED for acute care with planned discharge from ED. Exclusion Criteria: 1. Medically diagnosed with traumatic brain or orthopedic injury in the last year (TRACK-VA Control Subjects are not excluded for orthopedic injuries) 2. Significant polytrauma that would interfere with follow-up and outcome assessment 3. Prisoners or patients in custody 4. Patients on psychiatric hold (e.g. 5150, 5250) 5. Low likelihood follow-up (participant or family is indicating low interest, homelessness, out of state/country) 6. Current participation in an interventional trial 7. Penetrating TBI 8. Spinal cord injury with ASIA score of C or worse 9. Acute disabling neurological injury (e.g. acute stroke, cardiac arrest) TRACK-GERI/VA STUDY PARTNERS OF CONTROL SUBJECTS INCLUSION/EXCLUSION CRITERIA Inclusion Criteria: 1. Age 18 years or older 2. Designated by the control subject as someone who knows the subject well enough to comment on their health and functional starus (e.g., may be family member, friend, caregiver, case manager, etc.) 3. Ability to read, write and speak English/Chinese (UCSF only) 4. Ability to provide informed consent for self Exclusion Criteria: 1. Pre-existing and major disabling medical, psychiatric, or other neurological disease (e.g. dementia) that interferes with ability to provide evaluation of control subject's health and functional status. 2. Prisoners or in custody 3. On psychiatric hold (e.g. 5150, 5250)

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Conditions

The condition(s) this trial relates to.

Brain Injuries, Traumatic traumatic brain injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    3 sites. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • San Francisco Veterans Affairs Medical Center

    San Francisco, California, 94121, United States

  • University of California, San Francisco

    San Francisco, California, 94110, United States

  • University of Pittsburgh

    Pittsburgh, Pennsylvania, 15213, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.