New brain training may ease daily struggles for veterans with mild TBI
NCT ID NCT02920788
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a cognitive training program called GOALS for veterans who have had a mild traumatic brain injury (mTBI) and still have trouble with attention and daily tasks. The program teaches mindfulness and goal-management skills through real-life activities. Researchers will see if it improves thinking and daily function compared to usual care.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Goal-Oriented Attentional Self-Regulation (GOALS) cognitive training program
- What this could lead to
- If it works, this could provide an effective, non-drug therapy to help veterans with mild TBI improve attention and manage daily life better.
- What could go wrong
- This is a small, early-stage study (65 participants) testing a behavioral intervention, so results may not apply broadly. The training requires active participation and may not help everyone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 65 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Mar 2017
- Expected to finish
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Apr 2027
An estimate. End dates often move.
- Lead sponsor
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A government agency
The lead sponsor is a US federal agency other than the NIH.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: For TBI-positive veteran participants, to be randomized to either GOALS or TAU: * Ages 18+ * A history of mild TBI (as defined by DOD / VA; confirmed by medical records and in person Ohio State University TBI Instrument) * Chronic, stable phase of recovery (\>6 months from last post-concussive event) * Report of residual cognitive difficulties (1 moderate or severe cognitive symptom(s) on the Neurobehavioral Symptom Inventory (NSI)) that interfere(s) with daily function * Able and willing to commit to participate in training and assessments * If on psychoactive medications, must be stable on medications (\> 30 days) For the TBI-negative healthy veteran control group: * Ages 18+ * No history of any (mild to severe) TBI (as defined by DOD / VA; confirmed by medical records and in person Ohio State University TBI Instrument) * Able and willing to commit to participate in assessments * If on psychoactive medications, must be stable on medications (\> 30 days) Exclusion Criteria: For the TBI-positive veteran participants, to be randomized to either GOALS or TAU: * A history of moderate or severe TBI * Unstable medical, neurologic, or psychiatric condition, including severe cognitive dysfunction, or other reasons for being unable or unwilling to participate in study procedures (e.g., contraindications to MRI) * Ongoing illicit drug or alcohol abuse (AUDIT\>8) * Psychosis * Severe depression, anxiety or PTSD that precludes participation in research activities * Poor English comprehension * Eligible participants may have other co-morbid stable neuropsychiatric disorders, including depression and PTSD * There will be no restriction in regard to gender, race and socioeconomic status For the TBI-negative healthy veteran control group: * A history of any mild, moderate, or severe TBI * Unstable medical, neurologic, or psychiatric condition, including severe cognitive dysfunction, or other reasons for being unable or unwilling to participate in study procedures (e.g. contraindications to MRI) * Ongoing illicit drug or alcohol abuse (AUDIT\>8) * Psychosis * Severe depression, anxiety or PTSD that precludes participation in research activities * Poor English comprehension * Eligible participants may have other co-morbid stable neuropsychiatric disorders, including depression and PTSD. * There will be no restriction in regard to gender, race and socioeconomic status
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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San Francisco VA Medical Center, San Francisco, CA
COMPLETEDSan Francisco, California, 94121-1563, United States
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University of California, San Francisco
RECRUITINGSan Francisco, California, 94158, United States
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