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New brain training may ease daily struggles for veterans with mild TBI

NCT ID NCT02920788

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a cognitive training program called GOALS for veterans who have had a mild traumatic brain injury (mTBI) and still have trouble with attention and daily tasks. The program teaches mindfulness and goal-management skills through real-life activities. Researchers will see if it improves thinking and daily function compared to usual care.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Goal-Oriented Attentional Self-Regulation (GOALS) cognitive training program
What this could lead to
If it works, this could provide an effective, non-drug therapy to help veterans with mild TBI improve attention and manage daily life better.
What could go wrong
This is a small, early-stage study (65 participants) testing a behavioral intervention, so results may not apply broadly. The training requires active participation and may not help everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 65 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2017

Expected to finish

Apr 2027

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a US federal agency other than the NIH.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: For TBI-positive veteran participants, to be randomized to either GOALS or TAU: * Ages 18+ * A history of mild TBI (as defined by DOD / VA; confirmed by medical records and in person Ohio State University TBI Instrument) * Chronic, stable phase of recovery (\>6 months from last post-concussive event) * Report of residual cognitive difficulties (1 moderate or severe cognitive symptom(s) on the Neurobehavioral Symptom Inventory (NSI)) that interfere(s) with daily function * Able and willing to commit to participate in training and assessments * If on psychoactive medications, must be stable on medications (\> 30 days) For the TBI-negative healthy veteran control group: * Ages 18+ * No history of any (mild to severe) TBI (as defined by DOD / VA; confirmed by medical records and in person Ohio State University TBI Instrument) * Able and willing to commit to participate in assessments * If on psychoactive medications, must be stable on medications (\> 30 days) Exclusion Criteria: For the TBI-positive veteran participants, to be randomized to either GOALS or TAU: * A history of moderate or severe TBI * Unstable medical, neurologic, or psychiatric condition, including severe cognitive dysfunction, or other reasons for being unable or unwilling to participate in study procedures (e.g., contraindications to MRI) * Ongoing illicit drug or alcohol abuse (AUDIT\>8) * Psychosis * Severe depression, anxiety or PTSD that precludes participation in research activities * Poor English comprehension * Eligible participants may have other co-morbid stable neuropsychiatric disorders, including depression and PTSD * There will be no restriction in regard to gender, race and socioeconomic status For the TBI-negative healthy veteran control group: * A history of any mild, moderate, or severe TBI * Unstable medical, neurologic, or psychiatric condition, including severe cognitive dysfunction, or other reasons for being unable or unwilling to participate in study procedures (e.g. contraindications to MRI) * Ongoing illicit drug or alcohol abuse (AUDIT\>8) * Psychosis * Severe depression, anxiety or PTSD that precludes participation in research activities * Poor English comprehension * Eligible participants may have other co-morbid stable neuropsychiatric disorders, including depression and PTSD. * There will be no restriction in regard to gender, race and socioeconomic status

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Conditions

The condition(s) this trial relates to.

Brain Injuries, Traumatic traumatic brain injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • San Francisco VA Medical Center, San Francisco, CA

    COMPLETED

    San Francisco, California, 94121-1563, United States

  • University of California, San Francisco

    RECRUITING

    San Francisco, California, 94158, United States

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