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Brain scans reveal why head injuries can harm the heart

NCT ID NCT06958406

Knowledge-focused Sponsor: Shanghai 6th People's Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how a traumatic brain injury (TBI) can lead to heart problems like irregular heartbeat or heart failure. Researchers will use MRI scans to see if damage to certain brain areas disrupts the network that controls the heart. By studying 90 people with mild to moderate TBI, they hope to find brain targets that could be stimulated to prevent these heart complications.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could identify specific brain areas to target with noninvasive stimulation to prevent heart problems after a head injury.
What could go wrong
This is an early observational study with only 90 participants, so results may not apply to everyone. It aims to understand the brain-heart connection, not to test a treatment directly.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 90 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2025

Expected to finish

Jul 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Traumatic brain injury patients and healthy volunteers.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients with isolated closed head trauma * Age 18-80 years old * Admitted to hospital within 24 hours of injury * Mild or moderate TBI (Glasgow Coma Scale score of 9-15) * Signed consent form Exclusion Criteria: * Severe TBI (Glasgow Coma Scale score of 3-8) * A history of stroke, TBI, intracranial tumor or surgery in the past 1 year * A history of coronary heart disease, structural heart disease and other primary heart diseases or suspected cardiac symptoms prior to injury * Causes of abnormal cardiac biomarkers such as renal insufficiency, severe anemia, sepsis, cardiotoxic drugs and so on * Not suitable for MRI examinations, such as pregnant women and those with metal implants in the body * Undergo surgery prior to MRI examinations or cardiac testing

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Conditions

The condition(s) this trial relates to.

Alagille syndrome Brain Injuries, Traumatic neurocirculatory asthenia traumatic brain injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cerebrocardiac syndrome Traumatic brain injury

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Shanghai 6th People's Hospital

    RECRUITING

    Shanghai, 200233, China

  • Shanghai Sixth People's Hospital

    RECRUITING

    Shanghai, China

More trials for these conditions

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