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Could head injuries trigger a strange sleep disorder? new study investigates

NCT ID NCT06270290

Knowledge-focused Sponsor: Guy's and St Thomas' NHS Foundation Trust Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This observational study is recruiting 140 people to see if a history of concussions or playing contact sports is more common in those with REM sleep behavior disorder (RBD) compared to those without. RBD causes people to physically act out their dreams. Participants will answer questions about past head injuries and sports. The goal is to understand possible links, not to test a treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If this study finds a link, it could point to head injuries as a risk factor for RBD, helping with earlier detection or prevention.
What could go wrong
This is an early observational study, not a treatment trial. It cannot prove cause and effect, only show an association. Results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 140 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2024

Expected to finish

Sep 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients with a diagnosis of RBD at the Sleep Disorders Centre (Guy's and St Thomas' NHS Foundation Trust) will be identified via the sleep clinics. Expected number of eligible participants are 100, from which we expect 80 to agree to participate. An age- and sex-matched control group of 60 participants will be obtained also via the Sleep Disorders Centre clinics (Guy's and St Thomas' NHS Foundation Trust).

Ages

50 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria group with RBD: * Patient at the SDC with diagnosis of RBD (Guy's and St Thomas' NHS Foundation Trust). * 50 years of age or above (patients below this age would not be expected to have a RBD related to a synucleinopathy and other causes of RBD would need to be considered instead - e.g. narcolepsy, post-traumatic stress disorder). Inclusion criteria control group: * Patients who have undergone a v-PSG at the SDC (Guy's and St Thomas' NHS Foundation Trust) and who do not have history of suspected RBD or RBD confirmed by v-PSG. * 50 years of age or above This group will be age- and sex-matched to the RBD group. Exclusion criteria group with RBD: * Age \< 50 years of age. * Diagnoses of narcolepsy or post-traumatic stress disorder. * Subjects lacking capacity or literacy. * Non-English speakers. Exclusion criteria control group: * Age \< 50 years of age (in order to match RBD group). * REM sleep without atonia or confirmed RBD on v-PSG. * Diagnosis of neurological diseases, cognitive complaints or motor complaints. * Clinical history suggestive of parasomnia that may be included in the differential of RBD. * Subjects lacking capacity or literacy. * Non-English speakers.

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Conditions

The condition(s) this trial relates to.

Brain Concussion REM sleep behavior disorder traumatic brain injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Concussion, brain Rem sleep behavior disorder

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Guy's & St Thomas' NHS Foundation Trust

    RECRUITING

    London, London, SE1 9RT, United Kingdom

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