Spinal injury heart risk under the microscope
NCT ID NCT07456722
First seen Jun 27, 2026 · Last updated Aug 28, 2026 · Updated 2 times
Summary
This study looks at whether people with long-term spinal cord injury who also have a condition called autonomic dysreflexia (sudden high blood pressure) have changes in their heart structure. Researchers will use MRI scans to compare two groups: 24 people with high-level injury and dysreflexia, and 24 people with low-level injury without dysreflexia. The goal is to understand if dysreflexia is a hidden risk factor for heart problems.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 48 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jun 2026
- Expected to finish
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Oct 2028
An estimate. End dates often move.
- Lead sponsor
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A research network
The lead sponsor is a research network or cooperative group.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Participants will be recruited from all patients with a chronic spinal cord injury arriving for a routine urology check-up at the Swiss Paraplegic Center in Nottwil, Switzerland
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * adults aged 18 years or older * long-term (\>10 years), motor-complete SCI/D (AIS A and B) * Group A (24 individuals): high-level (\>Th6) SCI/D and autonomic dysreflexia * Group B (24 individuals): low-level (\<Th10) SCI/D without autonomic dysreflexia * signed informed consent Exclusion Criteria: * congenital heart defects * valvular disease(s) * cardiomyopathy * medium to severe arrhythmia * myocardial infarction * comorbidities causing morphologic heart changes including primary hypertension, aortic stenosis * comorbidities causing arterial hypertension * use of anti-hypertensive treatment * smokers * individuals after sacral deafferentation surgery * pregnancy * active implanted medical devices * claustrophobia * inability to comply with the measurement procedures
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Swiss Paraplegic Center
RECRUITINGNottwil, 6207, Switzerland
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Heart-Thickening drug trial aims to reverse damage
- Spinal stimulation may steady blood pressure in paralyzed patients
- Spinal stimulation may help bladder and blood pressure after injury
- Spinal cord injury study reveals body's hidden stress during routine catheterization
- Could a simple spray prevent dangerous blood pressure spikes after spinal injury?