Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

Could a simple spray prevent dangerous blood pressure spikes after spinal injury?

NCT ID NCT05635851

Prevention Sponsor: Simon Fraser University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 trial tests whether a nitric oxide spray (glyceryl trinitrate) can prevent dangerous blood pressure spikes during bowel care in people with spinal cord injury. 26 participants will receive either the active spray or a placebo during two at-home bowel care sessions. The study measures blood pressure changes and symptoms to see if the drug is safe and effective in real-world use.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
glyceryl trinitrate (nitric oxide donor) sublingual spray
What this could lead to
If it works, this could offer a simple, at-home way to prevent dangerous blood pressure spikes during bowel care for people with spinal cord injury.
What could go wrong
This is a small, early-phase trial with only 26 participants, so results may not apply to everyone. The drug may not work as expected or could cause side effects like low blood pressure or headache.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 26 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Dec 2026

An estimate. Start dates often move.

Expected to finish

Feb 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

19 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * participants must have had a traumatic spinal cord injury at least one year ago * regular bowel care routine * can communicate in English Exclusion Criteria: * cauda equina or conus lesions * currently use ventilator * colostomy, or do not perform regular bowel care * skin breakdown (pressure sores) * cannot communicate in English * under 19 years old * possibly or certainly pregnant * medical/psychiatric condition or substance abuse that is likely to affect ability to complete study * currently using medications containing PDE-5 inhibitors * currently using medications containing GTN * allergy to GTN

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Autonomic dysreflexia are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

autonomic dysreflexia spinal cord injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Autonomic dysreflexia Spinal cord injuries

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

More trials for these conditions

Other studies related to the condition(s) this trial covers.