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Simple cuff technique may boost heart health in spinal cord injury

NCT ID NCT07488793

Disease control Sponsor: Washington University School of Medicine Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a simple, home-based technique called remote ischemic conditioning can improve heart health in people with spinal cord injury. Participants will use a blood pressure cuff to briefly restrict blood flow to an arm, then release it, repeating this several times a day. The goal is to see if this approach is feasible and can improve blood vessel function and reduce inflammation.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
remote ischemic conditioning using a blood pressure cuff
What this could lead to
If this works, it could offer a simple, low-cost way to improve heart health and reduce cardiovascular risk in people with spinal cord injury.
What could go wrong
This is a very small pilot study (24 people) testing feasibility, not effectiveness. The intervention is experimental and may not produce meaningful health improvements.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 24 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2026

Expected to finish

Jul 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 18 years of age or older * Diagnosis of SCI * Live within the community (not nursing facility) * Not actively engaged in physical activity for exercise * Not having the ability to participate in physical activity due to physical capacity or environmental barriers * Medically stable * Ability to obtain physician approval to participate in the study * Willingness to participate in a 2-day initial assessment visit at research testing location, 30 intervention sessions conducted independently by the participant or caregivers, 2-day post intervention assessment visit at research testing location. Exclusion Criteria: * Medically unstable * Have had a heart-related condition within the past year * Have had a blood clot in the past year * Have a stage 3 or 4 pressure injury * Have taken blood thinners in the past year * Have had surgery in the past year * Have uncontrolled hypertension * Have peripheral artery disease * Have Complex Regional Pain Syndrome (CRPS) in both arms * Have had nerve or tendon transfers in the arms in the past year * Have lymphedema in the arms * Have recent acute illness or injury (within the past 3 months) * Currently pregnant * Enrolled in another clinical trial * Are taking GLP-1 medications * Unable to provide consent * Currently engaged in physical activity for exercise

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Conditions

The condition(s) this trial relates to.

spinal cord injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Spinal cord injuries

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Washington University School of Medicine

    RECRUITING

    St Louis, Missouri, 63108, United States

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