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Could deep breathing help your jaw pain? new study combines physical therapy with nerve stimulation

NCT ID NCT05272488

Symptom relief Sponsor: University of Alcala Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether adding a simple nerve-stimulation technique (using deep breathing to activate the vagus nerve) to standard physical therapy can better reduce pain and improve jaw movement in people with jaw joint disorders. Sixty adults with jaw muscle pain will receive either physical therapy alone or physical therapy plus the nerve stimulation over four sessions. The goal is to see if the combined approach leads to greater pain relief and better quality of life.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2022

Expected to finish

Sep 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Clinical diagnosis of myogenic pain according to the CD / TTM diagnostic criteria. * Presence of pain during the last 30 days. * Patients with decreased jaw function and mobility due to pain. * Patients who have not received physiotherapy treatment in the last 3 weeks. * Patients of legal age. Exclusion Criteria: * Patients with drug treatment: sedatives, anti-inflammatories, antidepressants, anxiolytics or muscle relaxants. * Patients with cardiac pacemakers and implanted defibrillators. Patients diagnosed with severe cardiorespiratory and / or respiratory diseases, carcinogenic processes, infectious processes and / or systemic pathologies. * Clinical diagnosis of temporomandibular disorder of joint or mixed origin according to the Diagnostic Criteria for Temporomandibular Disorders (CD / TMD). * Patients with psychiatric or psychological disorders, intellectual or motor deficiencies that, due to their nature, prevent them from correctly performing the prescribed exercises, correctly following the physiotherapist's instructions or understanding the questionnaires and / or measurement scales of the variables. * Patients with dental processes scheduled during the study period or who have undergone surgery in the last 3 months. * Patients with suspicion or certainty that their pain has appeared as a consequence of a local or general trauma. * Patients diagnosed with fibromyalgia, neuropathic pain or degenerative diseases

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Conditions

The condition(s) this trial relates to.

myofascial pain syndrome Pain temporomandibular joint disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pain Temporomandibular joint disorders

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The study's own enquiry address

    This study publishes an address for enquiries. See it below .

  2. The places running it

    3 sites. The list below names each one and where it is.

  3. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  4. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Clinical University Physiotherapy and pain

    RECRUITING

    Alcalá de Henares, Madrid, 2805, Spain

  • Martinez-Merinero, Patricia

    RECRUITING

    Alcalá de Henares, Madrid, 28805, Spain

    Contact Email: •••••@•••••

  • Physioterapy and Pain center research

    RECRUITING

    Alcalá de Henares, Madrid, 28805, Spain

    Contact Email: •••••@•••••

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