Temporomandibular joint disorder

This trial tests whether a dental compass and its software can create more accurate therapeutic splints for people with temporomandibular joint (TMJ) dysfunction and pain. It compares a group using this 3D-guided method to a group using manual fabrication, looking at the number o…

This trial compares two surgical techniques for treating a painful jaw condition called disc displacement without reduction, where the jaw's cushioning disc slips out of place and limits mouth opening. Participants will receive either arthroscopic lysis and lavage, a procedure th…

This trial compares two arthroscopic procedures for treating painful jaw joint disc displacement with reduction. One procedure involves rinsing the joint and releasing adhesions, while the other adds further tissue adjustment. The study will see which method better improves mouth…

This study tests whether botulinum toxin (Botox) injections into the jaw muscle can reduce pain and alter pain-related gene activity in people with painful jaw disorders. Half of the 100 participants receive Botox, the other half a placebo (saline). Researchers compare pain level…

This phase 3 trial tests whether injecting a concentrate of your own bone marrow (BMAC) into the jaw joint during arthroscopy reduces pain and damage better than a standard steroid shot. Twenty adults with long-lasting TMJ pain will be randomly assigned to one of the two treatmen…

This study tests whether injecting a mixture of hyaluronic acid and I-PRF (a concentrate of healing factors from your own blood) into the jaw joint, after a cleaning procedure called arthrocentesis, can reduce pain and improve jaw movement in people with a displaced disc. Partici…

This study compares two types of hip replacement materials in 100 adults aged 18 to 65 who need a total hip replacement. One group gets a ceramic-on-polyethylene implant where the polyethylene is infused with vitamin E to reduce wear. The other group gets a standard ceramic-on-ce…

This study aims to see if a special MRI designed for teeth can diagnose jaw joint disorders, tooth infections, and help plan dental implants as well as or better than traditional X-rays. About 470 adults needing dental imaging will get both an MRI and standard X-rays, and the res…

This study is testing a computer program called DystoniaNet that uses artificial intelligence to help doctors diagnose isolated dystonia, a movement disorder. The trial will enroll 1000 people with dystonia or other conditions that look like it, such as Parkinson's disease or ess…

This pilot study will test whether a non-invasive vagus nerve stimulation (nVNS) device can reduce jaw pain and improve mood in 10 premenopausal women with temporomandibular disorders (TMD). Participants will receive the treatment twice a week for 8 weeks and undergo brain scans,…

This study compares a new injection of liquid phase concentrated growth factor (LPCGF) to standard arthrocentesis (joint washing) for people with painful jaw clicking and limited mouth opening due to a displaced disc. Thirty-two adults aged 18-45 with unilateral disc displacement…

This study tests whether adding dry needling to standard physical therapy helps people with jaw pain (TMJ dysfunction). One hundred adults will either get standard rehab alone or rehab plus dry needling. Researchers will measure pain, jaw movement, and quality of life to see if t…

This trial tests whether a specific type of manual therapy, based on the Fascial Distortion Model, can reduce pain and improve function in people with temporomandibular disorders (TMD), which cause jaw, face, or neck pain. Participants are randomly assigned to receive either the …

This study is testing whether applying a special mud (peloid) to the jaw and chewing muscles can reduce pain and improve jaw function in adults with temporomandibular joint (TMJ) disorders. Forty participants will receive 20-minute mud treatments five days a week for two weeks. R…

This study tests whether a 2-week gratitude journaling activity is feasible and acceptable for people with temporomandibular disorder (TMD) and other chronic pain conditions. Sixty participants will either write down things they are grateful for or reflect on daily activities. Re…

This study is testing whether open-label placebo pills—capsules with no active ingredients that patients know are fake—can reduce chronic pain and improve sleep in people with temporomandibular disorder (TMD). About 111 participants will be split into three groups: one gets the p…

This study tests a short, two-session telehealth program called Physical Self-Regulation for people with chronic masticatory muscle pain (jaw pain). Participants will be randomly assigned to either this program or a control session that teaches about jaw anatomy. The goal is to s…

This study tests a wearable device that uses mild electrical pulses to relieve pain from temporomandibular disorders (TMD), which cause jaw, face, and headache pain. About 40 people aged 12 and older with chronic TMD will use the device at home for several weeks. The goal is to s…

This study tests a small, non-invasive device that delivers mild electrical pulses to the ear to see if it can help people with chronic jaw pain (TMD). About 40 adults will use the device at home daily for a few weeks. The main goal is to see if people find it easy and comfortabl…

This study tests whether a special laser device (Erchonia EVRL) can temporarily ease chronic jaw pain caused by TMJ disorder. Researchers will compare the laser to a placebo in 64 adults who have had constant jaw pain for at least 3 months. The main goal is to see if more people …

This study looks at whether adding a simple nerve-stimulation technique (using deep breathing to activate the vagus nerve) to standard physical therapy can better reduce pain and improve jaw movement in people with jaw joint disorders. Sixty adults with jaw muscle pain will recei…

This study looks at whether adding a structured exercise program to standard mouthguard (occlusal splint) therapy can better reduce jaw pain and improve function in people with temporomandibular disorders (TMD). About 38 adults with TMD will either receive the mouthguard alone or…

This study tests whether focused shock wave therapy can reduce pain and improve jaw function in people with temporomandibular disorders (TMD) of muscular origin. One hundred adults with moderate to severe jaw pain for at least 3 months will receive either shock wave therapy or a …

This study tests two ways to manage pain after hip replacement surgery. One group gets a nerve block plus a second nerve block; the other gets a nerve block plus wound numbing. The goal is to see which method reduces pain and the need for opioid painkillers. About 102 adults havi…

This study tests whether online or group physiotherapy can be as effective as individual in-person sessions for treating jaw muscle pain (TMD). About 90 adults with jaw muscle pain will be randomly assigned to one of three treatment formats. The goal is to find more accessible wa…

This study looks at a dental procedure called occlusal equilibration for people with long-term jaw pain (TMD). Researchers want to see if it still reduces pain 10 years later compared to a fake treatment. About 110 adults who had the procedure at a university clinic will be follo…

This study tests a mind-body therapy called Body Awareness Therapy (BAT) for adults with jaw joint disorders. It aims to reduce pain, improve jaw function, and ease anxiety or stress. About 52 adults will be randomly assigned to BAT or standard physiotherapy. Results may show if …

This study tests two noninvasive treatments for jaw muscle pain (TMD): a standard mouth splint and a newer ear stent. About 32 adults with moderate to severe pain will be randomly assigned to one treatment. Researchers will measure changes in muscle activity, mouth opening, and p…

This study compares two common physical therapy techniques—Mulligan and Maitland mobilization—for treating temporomandibular joint (TMJ) dysfunction, which causes jaw pain and limited movement. Thirty adults with TMJ pain will be randomly assigned to one of the two techniques, co…

This study tests whether adding specific orofacial and tongue exercises to standard manual therapy can reduce pain and improve jaw function in adults with temporomandibular disorders (TMD). 48 participants will receive either manual therapy alone or manual therapy plus exercises …

This study looks at whether a self-management program—including education, exercises, and mind-body techniques—can reduce pain in people with chronic orofacial pain and temporomandibular disorders (TMD). About 98 adults will be randomly assigned to either the self-management grou…

This study tests a light-based treatment called photobiomodulation (PBM) for pain caused by temporomandibular disorder (TMD). About 130 adults with long-term jaw or face pain will receive either real PBM or a sham treatment to see if it reduces pain. The goal is to find a safe, n…

This study tests whether a stabilizing occlusal splint (a type of mouthguard) can reduce tinnitus (ringing in the ears) in people who also have temporomandibular joint (TMJ) disorder. Researchers will compare the real splint to a placebo splint in 63 adults over 4 months, measuri…

This study tests whether adding pain neuroscience education (PNE) to standard physiotherapy helps people with chronic jaw pain more than physiotherapy alone. 36 adults with temporomandibular disorder (TMD) will be randomly assigned to either physiotherapy only or physiotherapy pl…

This pilot study is testing whether low-dose radiation can safely reduce pain from arthritis of the temporomandibular joint (jaw joint). Ten adults over 50 with diagnosed TMJ arthritis will receive six small doses of radiation over two weeks. Researchers will track pain levels an…

This study tests whether a gentle hands-on treatment called osteopathic manual therapy can reduce jaw pain and improve jaw function in people with fibromyalgia. About 114 adults with both conditions will receive either real or sham therapy. Researchers will measure pain, jaw move…

Researchers at Semmelweis University are studying how orthognathic surgery, which realigns the upper and lower jaws, affects the temporomandibular joint and jaw movement. Fifty adults aged 18 to 45 with severe dentofacial deformities take part. Using a digital facebow device call…

This study is a registry that will collect information from about 200 people who receive a total jaw joint (TMJ) replacement. Researchers will track their health, jaw function, and any complications for up to 5 years after surgery. The goal is to learn more about how these replac…

This study is testing a new type of dental MRI (ddMRI) to see if it can work as well as standard dental X-rays for diagnosing problems like crowded teeth, jaw pain, and infections. About 300 adults will get a ddMRI scan and then compare the results to their regular dental images.…

This study investigates whether people with chronic temporomandibular disorders (TMD) have a less effective natural pain inhibition system compared to healthy individuals. Researchers will apply carefully controlled heat stimuli to the face and other body parts to measure how wel…

This study follows 91 people who had jaw joint surgery (arthroscopy or disc removal) about 10 years ago. Researchers want to see if the improvements seen at 6 months still hold up over the long term, and how the joint changes on X-rays over time. The goal is to understand how sta…

This study will follow 200 people who have had a complex or revision hip replacement at University Hospitals Leuven. The goal is to track how many need another surgery and why, and to improve care by learning from real-world results. No new treatment is being tested—this is an ob…

This study looks at how chronic jaw pain (TMD) influences drinking patterns in heavy drinkers. Researchers will compare people with and without TMD pain, measuring how they drink alcohol in a lab setting and in daily life. The goal is to understand why pain increases the risk of …

This study looks at how immersive virtual reality changes the way the brain processes chronic pain, compared to a placebo effect. Researchers will measure brain activity and pain tolerance in 78 adults with temporomandibular disorder (jaw pain). The goal is to develop new, low-ri…

This study is looking at how problems with the jaw, neck, and head position relate to the severity of temporomandibular disorder (TMD), a condition that causes jaw pain and dysfunction. Researchers will assess 60 adults using questionnaires and physical measurements. The goal is …

This study will track jaw muscle activity in 42 adults with chronic jaw pain and teeth grinding (bruxism) who use a custom mouth splint at night. Participants will wear a portable device for 24 hours to measure muscle activity before starting the splint, two weeks later, and afte…

This study uses a special real-time MRI technique to watch how the jaw joint moves in healthy people and in those with temporomandibular joint (TMJ) disorders. By comparing the motion patterns, researchers hope to better understand what goes wrong in TMJ disorders. The study invo…

This study looks at how emotional intelligence—the ability to understand and manage emotions—relates to chronic orofacial pain (pain in the face or mouth lasting over three months). Researchers will compare 88 adults with and without this pain using questionnaires about emotions,…

This study looks at how chewing sugar-free gum for up to 18 minutes affects jaw muscle fatigue in 30 young adults, half with temporomandibular joint (TMJ) disorders and half without. Participants chew gum in 3-minute cycles, rating their fatigue and having muscle activity measure…

This study looks at whether standard, off-the-shelf jaw joint implants can be planned using 3D virtual software, just like expensive custom implants. Researchers will review X-rays from 30 patients who already had TMJ replacement surgery to see if virtual planning with standard i…

This study looks at how often people can return to sports at least three years after total knee replacement. It compares three different types of knee prostheses to see if one type leads to better sports participation. The study will include 660 adults who had their first knee re…

This study from Boston University is looking at how changes in the mouth, like wearing dental splints or dentures, can affect a person's balance and walking. Researchers will test 40 healthy adults, some with natural teeth and some with full dentures, using motion cameras and mus…

This study uses a smartphone app called SOMA to track daily mood, pain, and activity in 800 people with acute or chronic pain over four months. The goal is to find patterns that predict whether acute pain becomes chronic, or if chronic pain flares up. A smaller group will also ha…