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Which surgery unlocks a locked jaw? a Head-to-Head test

NCT ID NCT06782178

Disease control Sponsor: Karolinska Institutet Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 06, 2026 · Last updated Aug 07, 2026 · Updated 1 time

Summary

This trial compares two surgical techniques for treating a painful jaw condition called disc displacement without reduction, where the jaw's cushioning disc slips out of place and limits mouth opening. Participants will receive either arthroscopic lysis and lavage, a procedure that rinses the joint and breaks up adhesions, or arthrocentesis, a simpler irrigation, both under general anesthesia. The study will measure improvements in mouth opening, jaw pain, and disability over two years, and also look for factors that predict success. The goal is to determine which method offers better relief for people with this disabling condition.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Arthroscopic lysis and lavage (a surgical procedure to rinse the jaw joint and break up adhesions) compared to arthrocentesis (a blind irrigation of the joint with saline).
What this could lead to
If arthroscopic lysis and lavage proves superior, it could become the preferred surgical option for people with painful, locked jaw joints, offering better mouth opening and pain relief.
What could go wrong
This is a randomized trial with 100 participants, so results may not apply to everyone. Both procedures are invasive and carry risks such as infection, swelling, or temporary nerve irritation, and the study does not guarantee long-term benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2025

Expected to finish

Feb 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Uni- or bilateral DDwoR affecting the patients mouth opening capacity to a range of ≤ 35 mm, verified with clinical and magnetic resonance imaging (MRI) findings. * TMJ pain ≥ 3 (NRS) * TMJ disability ≥ 3 (NRS) * Age ≥ 18 years Exclusion Criteria: * Prior open TMJ surgery * Patient diagnosed with rheumatologic joint disease. * ASA (American Society of Anaesthesiologists) \> 3 * Patient unable to verify informed consent.

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Conditions

The condition(s) this trial relates to.

temporomandibular joint disorder temporomandibular joint dysfunction syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Temporomandibular disorders (TMD) Temporomandibular joint disc displacement Temporomandibular joint disc displacement, without reduction

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Karolinska Institutet

    RECRUITING

    Huddinge, 14104, Sweden

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