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Can AI unlock better jaw pain relief?

NCT ID NCT07771296

Disease control Sponsor: En Chu Kong Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 18, 2026 · Last updated Aug 21, 2026 · Updated 3 times

Summary

This trial tests whether combining AI with clinical exams and imaging can create a more targeted treatment plan for people with temporomandibular disorders (TMD), which cause jaw pain and limited movement. Participants receive either low-level laser acupuncture, proprioceptive training, or a combination, based on an AI-assisted diagnosis. The study aims to see if this tailored approach improves pain and jaw function while potentially reducing the need for MRI scans.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Low-level laser acupuncture and proprioceptive training
What this could lead to
If successful, this could lead to a more precise, AI-assisted approach for diagnosing and treating jaw joint disorders, potentially reducing the need for MRI scans and improving treatment outcomes.
What could go wrong
This is an early-stage study, and the AI-based framework may not prove more effective than standard care. Laser acupuncture and training may not relieve symptoms for all participants.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 180 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2026

An estimate. Start dates often move.

Expected to finish

Jul 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients diagnosed with temporomandibular disorders (TMDs) screened by the Department of Dentistry, Division of Oral and Maxillofacial Surgery at En Chu Kong Hospital, who have failed to respond to analgesic treatment for at least one week. * Patients clinically examined and identified as having pain predominantly originating from muscles associated with mandibular movement. * Patients aged between 18 and 70 years (inclusive) with full legal capacity. * Patients who are willing to participate in the study and provide written informed consent. Exclusion Criteria: * Patients meeting any of the following clinical scale thresholds: Generalized Anxiety Disorder-7 (GAD-7)≥ 10, Patient Health Questionnaire-9 (PHQ-9) ≥ 15, Patient Health Questionnaire-15 (PHQ-15) ≥ 10, or Pittsburgh Sleep Quality Index (PSQI) \> 5. * Patients with tumors of the temporomandibular joint (TMJ) or head and neck region. * Patients with acute or chronic infections. * Patients with a history of neuropathy or stroke. * Patients with a history of head and neck trauma. * Patients diagnosed with fibromyalgia. * Patients diagnosed with autoimmune or rheumatic diseases. * Patients diagnosed with irritable bowel syndrome (IBS). * Patients with claustrophobia (unable to undergo MRI examination). * Women who are pregnant or lactating, or parents currently in the infant care/nursing period. * Patients who have received invasive treatment for temporomandibular joint disorders within the past 3 months.

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Conditions

The condition(s) this trial relates to.

temporomandibular joint disorder temporomandibular joint dysfunction syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Temporomandibular disorders (TMD) TMJ disorder TMJ pain

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

More trials for these conditions

Other studies related to the condition(s) this trial covers.