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Jaw joint relief: could a natural protein mix beat standard care?

NCT ID NCT07683650

Disease control Sponsor: Mansoura University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 06, 2026 · Last updated Jul 15, 2026 · Updated 3 times

Summary

This study tests whether injecting a mixture of hyaluronic acid and I-PRF (a concentrate of healing factors from your own blood) into the jaw joint, after a cleaning procedure called arthrocentesis, can reduce pain and improve jaw movement in people with a displaced disc. Participants are adults aged 18 to 45 with a specific type of jaw joint problem. The trial compares four different treatment approaches to see which works best.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
hyaluronic acid and I-PRF (injectable platelet-rich fibrin) mixture
What this could lead to
If it works, this could offer a better way to reduce jaw pain and improve mouth opening for people with a common jaw joint problem, possibly reducing the need for more invasive treatments.
What could go wrong
This is a small, early-stage trial with only 72 participants, so results may not apply to everyone. The treatment involves a procedure and injection, which carry risks like infection or temporary discomfort.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 72 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2026

Expected to finish

Feb 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 45 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age: 18 - 45 years. 2. Patients with disc displacement with reduction in any of the TMJs. 3. arthralgia. 4. Limited unassisted mouth opening. 5. Co-operative patients. Exclusion Criteria: 1. Patients with previous history of TMJ minimally invasive interventions. 2. Patients with autoimmune or connective tissue diseases affecting the joints. 3. Patients with neurological disorders. 4. Patients with a history of condylar fractures or ankylosis. 5. Patients with psychological problems. 6. Patients receiving non-steroidal anti-inflammatory drugs within 48 hours preoperatively, or systemic use of corticosteroids within 2 weeks. 7. Patients on anticoagulants, suffering from platelet function disorders or fibrinogen deficiency. 8. Patients with moderate to severe myogenic pain.

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Conditions

The condition(s) this trial relates to.

temporomandibular joint dysfunction syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TMJ disc displacement with reduction

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Faculty of Dentistry Mansoura University

    RECRUITING

    Al Mansurah, Egypt

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