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Ultrasound vs. arthroscopy: which injection works better for TMJ pain?

NCT ID NCT07535073

Symptom relief Sponsor: Cairo University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests two methods of injecting platelet-rich fibrin (PRF) into the jaw joint for people with a displaced disc that causes pain and limited mouth opening. One method uses ultrasound to guide the needle, the other uses a tiny camera (arthroscope). The goal is to see which approach reduces pain and improves jaw function better. The trial will enroll 18 adults who have not improved with standard treatments like splints or physical therapy.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
platelet rich fibrin (PRF) injection
What this could lead to
If successful, this could show that a simpler, ultrasound-guided injection works as well as arthroscopic surgery for TMJ pain, offering a less invasive option.
What could go wrong
This is a very small early trial (18 people) comparing two procedures, so results may not apply widely. PRF injections may not provide lasting relief, and both procedures carry risks like infection or pain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 18 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

May 2026

An estimate. Start dates often move.

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged 18-60 years. * Clinically and radiographically diagnosed temporomandibular joint disc displacemet with reduction. * Presence of TMJ pain exacerbated by mandibular movement. * Limited mandibular function and/or reduced maximum mouth opening. * Symptoms persisting for at least 3 months. * Failure of conservative treatment (e.g. occlusal splint, physiotherapy, NSAIDs). -Ability to understand the study protocol and provide informed consent. Exclusion Criteria: * Previous TMJ surgery or arthroscopic intervention. * Intra-articular injection in the TMJ within the last 6 months. * Systemic inflammatory or autoimmune joint diseases. * Coagulation disorders or current anticoagulant therapy. * Active local infection at the injection site. * Pregnancy or lactation. * Severe degenerative joint disease (advanced osteoarthritis). * Known allergy or contraindication to ( PRF) preparation.

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Conditions

The condition(s) this trial relates to.

temporomandibular joint dysfunction syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TMJ disc displacement with reduction

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

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