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Chewing gum study seeks to uncover jaw fatigue secrets in TMJ sufferers

NCT ID NCT07273123

Knowledge-focused Sponsor: University of Milan Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how chewing sugar-free gum for up to 18 minutes affects jaw muscle fatigue in 30 young adults, half with temporomandibular joint (TMJ) disorders and half without. Participants chew gum in 3-minute cycles, rating their fatigue and having muscle activity measured. The goal is to see if people with TMJ disorders experience fatigue differently, which could inform future care.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
sugar-free chewing gum
What this could lead to
If successful, this could help understand how chewing affects jaw fatigue in people with TMJ disorders, potentially guiding future treatments or self-care advice.
What could go wrong
This is a small, early-stage observational study with only 30 participants. It measures fatigue during a short chewing task, not long-term outcomes, so results may not apply broadly.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2025

Expected to finish

Jul 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population will consist of volunteer participants recruited from the undergraduate dentistry program and postgraduate specialty training programs at the University of Milan.

Ages

19 to 35 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria (both groups): * Age 19-35 years * Chewing-gum users, even occasional * Good general health * Good oral health Inclusion criteria (Healthy controls): \- no diagnosed temporomandibular joint disorders Inclusion criteria (study group) \- diagnosed temporomandibular joint disorders Exclusion criteria (both groups): * Non chewing gum users * History of neurological disorders * History of musculoskeletal diseases * History of facial or cervical injuries * Presence of cervical pain * Two or more missing teeth * Current treatment with fixed or removable orthodontic appliances * Active periodontal disease * Presence of cavitated carious lesions

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Conditions

The condition(s) this trial relates to.

temporomandibular joint disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Temporomandibular joint disorder

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • University of Milan

    RECRUITING

    Milan, Milan, 20142, Italy

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