Pain management

This trial investigates whether adding a booster session and extended access to the rehabilitation team after standard interdisciplinary care can improve outcomes for people with chronic pain. Two hundred participants in Swedish primary healthcare will be randomly assigned to eit…

Researchers compare two medicines placed inside root canals during a two-visit root canal treatment for infected mandibular molars. One medicine is Hyalone, a hyaluronic acid gel, and the other is calcium hydroxide, a standard disinfectant paste. The trial enrolls 24 adults with …

This trial compares two ways to control pain after open liver surgery: an epidural pump that delivers pain medicine near the spine, versus a standard IV pump. About 230 adults having elective open liver resection will be randomly assigned to one method. The goal is to see which a…

This study tests whether adding a nerve stimulator to standard ultrasound guidance improves the quality of nerve blocks for upper limb surgery. 82 adults having elective arm surgery will be randomly assigned to receive the block with or without the stimulator active. Researchers …

This trial tests whether acupressure, a technique that applies gentle pressure to specific body points, can reduce pain, fear, and anxiety in children aged 6-12 during removal of K-wires (thin metal pins used to heal elbow fractures). Children will be randomly assigned to receive…

This trial asks whether an opioid-free anesthesia method can control acute pain after laparoscopic colorectal surgery as well as or better than standard opioid-based anesthesia. Adults aged 18 to 90 scheduled for this surgery will be randomly assigned to receive either a combinat…

This study compares three treatments for shoulder impingement and carpal tunnel syndrome: ultrasound-guided corticosteroid injections, standard injections guided by touch, and oral pain medication. Researchers want to see which approach provides the best long-term pain relief, im…

This study tests a computer dashboard that helps doctors and nurses in the Neonatal Intensive Care Unit (NICU) manage pain in newborn babies. The dashboard shows real-time data to flag when a baby may be in discomfort. Researchers will compare pain levels in 1,250 babies before a…

This study looks at whether adding dexamethasone or dexmedetomidine to the usual numbing medicine (bupivacaine) can improve pain relief after shoulder arthroscopy. About 100 adults having elective shoulder surgery will take part. The goal is to reduce pain and help recovery.

This study tests whether a long-acting numbing medication (liposomal bupivacaine) can better control pain after septorhinoplasty (nose surgery) compared to standard numbing drugs or a placebo. About 72 adults having nose surgery will receive one of three treatments at the end of …

This study compares three ways to manage pain after lower abdominal surgery: a spinal injection of morphine, a nerve block in the abdominal wall, or standard painkillers. Sixty-six adults having surgery through a midline incision will be randomly assigned to one of these groups. …

This study tests a device called Buzzy Bee that vibrates and cools the skin to distract children during a dental numbing shot. About 30 healthy kids aged 4-12 will try both the Buzzy Bee and standard care to see which hurts less. The goal is to make dental visits easier for child…

This study tests whether acupressure (applying pressure to specific points on the body) and back massage can reduce pain, fatigue, and improve sleep quality in women recovering from a cesarean section. About 111 new mothers will receive these non-drug treatments after surgery. Th…

This study tests whether a medication applied directly during shoulder replacement surgery (ZYNRELEF) can reduce the need for strong painkillers after the operation, compared to the standard method of using a nerve block with a catheter. About 86 adults having shoulder replacemen…

This study tests whether giving patients a pain education booklet and video before knee or hip replacement surgery helps them feel less anxious and have less pain afterward. About 70 adults scheduled for elective joint replacement will be randomly assigned to receive the educatio…

This study compares two types of nerve blocks (PECS II-PIFB vs. SAPB) to see which provides better pain relief for women undergoing modified radical mastectomy. Seventy women aged 18-65 will be enrolled, and the main goal is to measure how much extra pain medicine they need in th…

This study compares personalized electro-acupuncture and auricular-acupuncture against usual care for treating chronic pain in adults with musculoskeletal pain or fibromyalgia. Participants are split into three groups: two receive different acupuncture methods, and one receives s…

This study tests a program called COMPASS-NP for home care workers who have chronic pain. The program combines pain education, coping strategies, and safety tips, led by a trained peer. About 140 workers will take part to see if it reduces how much pain interferes with their work…

This study compares two procedures to relieve chronic tailbone pain (coccydynia) that is not related to cancer. About 74 adults aged 20-70 who have not responded to standard medical treatment will be split into two groups. One group will receive conventional radiofrequency ablati…

This study looks at whether using Montage or Montage-CT devices to close the breastbone after heart surgery can lower the need for strong painkillers like opioids. Researchers will review records from 150 adults who had planned heart surgery. They will compare opioid use and reco…

This study looks at whether cannabis oil can help reduce pain and improve sleep and quality of life in people with fibromyalgia who have not found relief from other treatments. Researchers will track pain levels, side effects, and how well patients stick to the treatment. The goa…

This study aimed to see if a team of doctors, nurses, and pharmacists working together could help people recover better after anorectal surgery. It planned to compare standard care with this team-based approach in 126 adults. However, the study was withdrawn before any participan…