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Can a targeted nerve block cut opioid use after gallbladder surgery?

NCT ID NCT07745972

Symptom relief Sponsor: Istinye University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 04, 2026 · Last updated Aug 11, 2026 · Updated 3 times

Summary

This trial tests whether an ultrasound-guided nerve block, using the anesthetic bupivacaine, can reduce pain and the need for opioid painkillers after laparoscopic gallbladder removal. Sixty adults with a healthy weight and low surgical risk will receive either the nerve block or a placebo before surgery. Researchers will measure pain scores, opioid use, and quality of recovery during the first 24 hours after the operation.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
An ultrasound-guided nerve block using bupivacaine, a local anesthetic, injected near the ribs to numb the area.
What this could lead to
If effective, this nerve block could offer a way to manage post-surgical pain with fewer opioids, potentially reducing side effects and speeding recovery.
What could go wrong
This is a small, early-stage trial, and the block may not provide significant pain relief for everyone. There are also risks like infection, bleeding, or allergic reaction to the anesthetic.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2026

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * BMI \< 35 kg/m² * Patients with ASA scores I and II Exclusion Criteria: * Patients who do not want to be included in the study * Psychiatric and neurological disease with blurred consciousness * Patients with ASA \> 3 * BMI \> 35 kg/m² * Abnormality in coagulation parameters * History of allergy to local anesthetic drugs * Infection at the injection site

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Conditions

The condition(s) this trial relates to.

agnosia pain agnosia Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Analgesia Pain management Pain, acute post-operative

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Istinye University Liv Topkapı Hospital

    RECRUITING

    Istanbul, 34050, Turkey (Türkiye)

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