ANALGESIA

This study is testing if a long-acting numbing medicine called Exparel, given during knee ligament surgery, helps children and teens (ages 13+) feel less pain and need fewer opioid painkillers in the week after their operation. Researchers will compare patients who receive Expare…

This study is testing a new way to decide when to give extra pain medicine after surgery. Researchers want to see if using a scale that measures both pain level and a patient's ability to move around leads to better decisions than using a pain number alone. They will compare two …

This study aims to find which of two drugs works better when added to a standard pain-blocking injection for patients having their thyroid gland removed. Researchers will compare dexmedetomidine and dexamethasone in 60 patients undergoing thyroid surgery to see which provides lon…

This study aims to find the best dose of a drug called dexmedetomidine to make a numbing nerve block last longer after arm surgery. Researchers will compare three different doses added to the standard numbing medicine. The goal is to provide patients with more extended pain relie…

This study aims to find out which of three common pain control methods works best to prevent long-term pain after open heart surgery. Researchers will observe 90 patients receiving standard pain treatments to see which method leads to less chronic pain three months after surgery.…

This study is testing if adding an anti-inflammatory drug (ketorolac) to the standard numbing shot (lidocaine) can better reduce pain for women undergoing a common uterine exam called hysteroscopy. It will compare the new combination shot to the standard shot alone in 60 women. T…

This study is testing if a specific nerve block given before hip replacement surgery helps patients recover better. Researchers will compare 60 patients who get the block to those who don't. They want to see if the block reduces pain after surgery, lowers the need for strong pain…

This study is testing whether combining two types of nerve blocks provides better pain relief than a single nerve block after knee realignment surgery. Researchers will measure how much opioid pain medication patients need and track their pain levels during recovery. The goal is …

This study aims to find the best way to deliver morphine for pain relief after planned cesarean sections. Researchers will compare pain control between morphine injected into the spinal fluid versus morphine injected into the epidural space near the spine. The trial involves 120 …

This study aims to find the safest and most comfortable way to relieve pain for adults while doctors set broken bones or fix dislocated joints in the emergency room. Researchers will compare different sedation and pain-blocking techniques used in routine care across three hospita…

This study is testing if a targeted numbing injection, called a TAP block, can reduce pain for patients undergoing common heart procedures like angiograms. Researchers will give the nerve block to some patients and compare their pain and satisfaction levels to patients who do not…

This study aims to see if giving a single dose of common painkillers like paracetamol (acetaminophen) or ibuprofen before nose surgery can reduce the amount of strong opioid pain medication needed during and after the operation. It will involve 54 adults undergoing elective septo…

This study is testing whether a special patch-like device can help reduce pain after a cesarean delivery, with the goal of helping women need less opioid pain medication. Researchers will compare the device to a fake version and to standard pain care in 180 women. The main thing …

This study is testing whether a new, long-lasting numbing medicine (liposomal bupivacaine) works better than a standard one (ropivacaine) at reducing pain after major abdominal surgery. Doctors will inject one of these medicines into the surgical area right before closing the inc…

This study is testing if a new type of nerve block can better control pain after minimally invasive heart bypass surgery. Sixty patients will be randomly assigned to receive either this new block or standard pain management. The main goal is to see if the block reduces the need f…

This study aims to find the best dose of the pain medication ketorolac for adults coming to the emergency room with severe kidney stone pain. Researchers will compare how well a 15mg dose works versus the standard 30mg dose to relieve pain over two hours. The goal is to provide e…

This study is testing whether a nerve-blocking injection given before jaw surgery can reduce pain and the need for strong painkillers afterward. It will involve 60 adults having planned jaw surgery. Researchers will measure how much pain medication patients need and how much pain…

This study is testing whether adding a nerve block to a standard steroid injection provides better pain relief for people with frozen shoulder. Researchers will compare pain levels, shoulder function, and medication use between the two approaches over 8 weeks. The trial involves …

This study compares two different nerve block techniques used to manage pain after open-heart surgery. Researchers want to see if one method provides better pain relief and helps patients breathe easier during recovery. The trial will involve 80 adults having their first heart su…

This study is testing if a high-dose nicotine patch can help control pain in men who smoke and are having chest surgery. The goal is to see if the patch reduces the need for strong opioid painkillers after the operation, which can have bad side effects. It's a small pilot study w…

This study is testing whether a precise nerve block, guided by ultrasound, can help control pain after middle ear surgery. The goal is to see if this method reduces the need for strong painkillers like morphine and improves patient comfort. Researchers are enrolling 56 adults und…

This study aims to understand why some people experience more pain after surgery than others. Researchers will observe 5,000 adults having elective surgery to see if their genes, along with other factors, are linked to severe pain, high painkiller use, or long-term pain. This is …

This study aims to understand what affects recovery and pain after weight-loss surgery. Researchers will follow 2,000 patients for up to 5 years, collecting information on their pain levels, side effects, and how surgery impacts their daily life and quality of life. The goal is t…

This study aims to find out if a low-dose buprenorphine skin patch is as good at relieving pain as the common pill oxycodone, but with a lower risk of abuse and addiction. Researchers will test 120 healthy adults who don't use opioids, giving them different doses of the patch, th…

This study aims to understand how a gentle electrical stimulation to the ear can reduce pain. Researchers are testing if this method works by triggering the body's own natural pain-relieving chemicals, called endogenous opioids. They will test this in 136 healthy volunteers by co…

This study aims to understand why some people have more complications after surgery than others. Researchers will follow 20,000 adults having planned surgery to see if factors like a person's genetics, the type of surgery, or anesthesia used are linked to problems like severe nau…