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Could a nicotine patch replace opioids for Post-Surgery pain in smokers?

NCT ID NCT07250230

Symptom relief Sponsor: Henan Provincial People's Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This pilot study is testing whether a high-dose nicotine patch can reduce pain and the need for opioid painkillers in male smokers who are having chest surgery. The patch is given before and after surgery. The study will track how much pain medication participants use. It includes 80 male smokers aged 18-75 who are undergoing lung surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
nicotine patch
What this could lead to
If it works, this could point toward a non-opioid way to manage pain after surgery for smokers, potentially reducing opioid side effects.
What could go wrong
This is a small pilot study with only 80 men, so results may not apply to everyone. Nicotine patches can cause side effects like skin irritation, dizziness, or nausea.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 80 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2025

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Male participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Male, aged 18-75 years, with a body mass index (BMI) of 18-28 kg/m2 Between; 2. Thoracoscopic lobectomy/segmental/wedge resection under general anesthesia; 3. American Society of Anesthesiologists (ASA) classifications I-III Level; 4. Regular smoking for more than 2 years, smoking more than 10 cigarettes per day in the past 6 months, and not successfully quitting smoking within 1 month (after admission, the doctor and nurse informed the smoking cessation plan to intervene before starting to stop smoking or 1 ≤ cigarette count ≤ 10 cigarettes/day in the past month), FTND score ≥ 2; 5. No severe respiratory diseases, no serious cardiovascular and cerebrovascular diseases (hypertension is treated with SBP ≤ 160mmHg, DBP ≤ 90mmHg after systemic treatment); 6. Obtain informed consent. Exclusion Criteria: 1. Those who have a history of alcoholism, long-term use of sedatives or analgesics; 2. Patients with psychiatric and nervous system diseases (such as Parkinson's, depression, schizophrenia) and severe audio-visual dysfunction before surgery; 3. Preoperative systolic blood pressure \> 180mmHg or diastolic blood pressure \> 110mmHg; 4. Patients who were converted to thoracotomy during thoracoscopic surgery 5. Patients who are transferred to the intensive care unit after surgery; 6. Patients who refuse to use analgesic pump treatment/do not configure the analgesic pump according to regulations; 7. Patients who have self-removed patches/short hospital stay resulting in a postoperative observation time of \< 48 hours

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Conditions

The condition(s) this trial relates to.

agnosia nicotine dependence pain agnosia Thoracic Diseases

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Analgesia Nicotine dependence Thoracic diseases

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Department of Anaesthesiology and Perioperative Medicine, People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou, Henan

    RECRUITING

    Zhengzhou, Henan, 450003, China

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