NICOTINE DEPENDENCE

This study tests whether the medication varenicline can help adults quit using e-cigarettes. About 326 people who vape daily will receive either varenicline or a placebo for 12 weeks, and researchers will check if they have stopped vaping at 12 and 26 weeks. The goal is to find a…

This study looks at whether e-cigarettes or nicotine pouches can help adults who smoke cigarettes cut down. About 256 people will be given one of these products to use for 4 weeks, with different flavors and nicotine levels. Researchers will track how many cigarettes they smoke a…

This study tests new treatments to help people with HIV quit smoking. Smoking is a major health risk for this group, causing more harm than HIV itself. The study will compare different approaches, including medication and support, to find what works best. About 340 adults with HI…

This study looks at whether tobacco-free nicotine pouches (like Zyn) can help people who smoke cigarettes switch to a less harmful option. Fifty adult smokers will use the pouches for 4 weeks and report their smoking habits. The goal is to see if pouches reduce or replace cigaret…

This study tests if a non-invasive brain stimulation technique called rTMS can help people with mental illness quit smoking. Forty daily smokers with a psychiatric condition will either receive rTMS or standard care. Researchers will also talk to patients and doctors to see if ad…

This study looks at whether starting a quit attempt during the first half of the menstrual cycle (follicular phase) helps women stop smoking more successfully than starting during the second half (luteal phase) or without cycle timing. About 1,200 women who smoke daily and have r…

This study is testing a new way to help people stop smoking by using pleasant smells to reduce cigarette cravings. Participants will use a smartphone app and a special device that delivers different odors. The goal is to see if sniffing specific scents can lower cravings and help…

This study tests whether a personalized exercise program can help smokers who are afraid of bodily sensations (like a racing heart) quit smoking. 360 adults will take part in a YMCA-based program. The goal is to see if exercise reduces smoking and helps people stay smoke-free for…

This study tests a social media-based program called the Quit the Hit Toolkit to help teens and young adults stop vaping. Researchers will train coaches to lead 5-week online support groups for participants aged 13-21 who vape regularly. The goal is to see if the program is pract…

This study tests a smartphone app called ACT on Vaping to help young adults (ages 18-30) quit using e-cigarettes. The app teaches skills to manage cravings and avoid triggers. Researchers will compare the app's effectiveness in helping participants stay nicotine-free for 30 days.

This study looks at whether cannabidiol (CBD) can reduce stress and withdrawal symptoms in people who smoke cigarettes. About 90 smokers will take CBD and then be exposed to stress. Researchers will measure mood, pain, heart rate, and stress hormones to see if CBD helps. Some par…

This study tests a free, internet-based program that uses mindfulness and behavioral strategies to help adults reduce or quit smoking and vaping. About 406 adults in Switzerland and Türkiye who smoke or vape will be randomly assigned to the program or a control group. The program…

This study looks at whether a high-dose nicotine patch placed on the skin before and after chest surgery can reduce pain and the need for strong painkillers in male smokers who have stopped smoking temporarily. About 80 men aged 18-75 who smoke regularly and are having lung surge…

This study tests whether adding ear acupressure (small seeds taped to ear points) to standard nicotine patches can better reduce cravings, withdrawal symptoms, and anxiety in psychiatric patients who must stop smoking while in the hospital. About 60 adults aged 18-65 will be rand…

This study tests a program called QuitVaping, which combines coaching and text message support, to help teens ages 14-18 quit vaping. About 400 teens who vape at least weekly will be randomly assigned to either the QuitVaping program or standard advice and resources. The main goa…

This study aims to understand whether relighting a cigarette (instead of smoking it all at once) increases the amount of harmful chemicals smokers inhale. Researchers will observe 30 smokers who regularly relight, measuring their smoking habits and collecting cigarette butts. No …

This study looks at how a beta-blocker (propranolol) and nicotine patches, alone or together, affect smokers' brain activity and cravings when they see smoking-related cues. About 80 daily smokers will have MRI scans and rate their urges. Participants do not try to quit or take t…

This study looks at how the amount of nicotine and how fast it enters the body affects a person's desire to smoke and the drug's addictive potential. Researchers will give nicotine through an IV to closely mimic smoking. The goal is to understand what makes nicotine addictive, wh…

This study tests whether suvorexant, a drug approved for insomnia, can reduce cravings and brain responses linked to smoking in daily smokers and vapers aged 18-60. Researchers will use brain scans and sleep tracking to see how the drug works over a few weeks. A separate group of…

This study looks at how the body handles synthetic nicotine compared to natural nicotine from tobacco. About 18 experienced e-cigarette users will try three types of nicotine liquid and have their blood, heart rate, and cravings measured. The goal is to understand if synthetic ni…

This study aims to develop better MRI techniques to see how drug addiction changes the brain. Researchers will scan the brains of up to 1,000 adults, including smokers, non-smokers, and people who use drugs or not. The goal is to improve our understanding of addiction and pave th…