Which additive makes a nerve block last longer for thyroidectomy pain?
NCT ID NCT05793060
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether adding dexmedetomidine or dexamethasone to a standard numbing medicine (bupivacaine) can improve pain control after thyroid removal. Sixty adults undergoing total thyroidectomy will receive one of the two combinations via an ultrasound-guided nerve block. Researchers will track pain scores and side effects for 24 hours after surgery.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Dexmedetomidine and dexamethasone (added to bupivacaine for a nerve block)
- What this could lead to
- If one drug works better, it could provide longer-lasting pain relief after thyroid surgery, helping patients recover more comfortably.
- What could go wrong
- This is a small, early-phase trial with only 60 participants. Results may not apply to everyone, and side effects like slow heart rate or nausea are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
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About 60 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Aug 2025
- Expected to finish
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Dec 2026
An estimate. End dates often move.
- Lead sponsor
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A government agency
The lead sponsor is a government body.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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21 to 60 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * American Society of Anesthesiologists (ASA) physical status ≤ II * Age from 21 to 60 years * Body Mass Index (BMI) ≤ 35 kg/m2 Exclusion Criteria: * ASA physical status \> II * Age \< 21 years or \> 50 years * BMI \> 35 kg/m2 * Bronchial asthma * Chronic obstructive pulmonary disease * Restrictive lung diseases * Sick sinus syndrome * Sinus bradycardia * Hypertension * Chronic hypotension * Ischemic heart disease * Coagulopathies * Hepatic insufficiency * Renal insufficiency * Diabetes mellitus * Peripheral neuropathy * Thyroid malignancy * Hyperthyroidism * Substernal goiter * Patients on beta-blockers * Patients using pacemakers * Alcohol or drug abuse * Allergy to the study drugs
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Damanhour Teaching Hospital
RECRUITINGDamanhūr, El-Beheira, Egypt
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