ANALGESIA

This study tests whether adding an extra nerve block (IPACK) to a standard one (adductor canal block) reduces pain and the need for strong painkillers after knee realignment surgery. About 100 adults aged 18-75 will participate. The goal is to find a better way to manage post-sur…

This study tests whether adding a pain-relieving drug (ketorolac) to the standard numbing medicine (lidocaine) can reduce pain during a hysteroscopy, a procedure to look inside the uterus. About 60 women will be randomly assigned to receive either the combination or lidocaine alo…

This study compares two types of nerve blocks (ESPB and PIFB) to see which one provides better pain relief and helps patients breathe easier after open-heart surgery. About 80 adults having their first heart surgery will take part. The main goal is to measure how much pain medici…

This study tests whether a lower dose (15mg) of the painkiller ketorolac works as well as a higher dose (30mg) for kidney stone pain in the emergency room. About 86 adults under 65 with moderate to severe pain will be enrolled. Researchers will measure pain levels over several ho…

This study compares three doses of a medicine called dexmedetomidine added to a standard numbing shot for arm surgery. The goal is to see if a higher dose keeps the arm numb and pain-free longer. About 69 adults having elbow, forearm, or hand surgery will take part.

This study tests a non-drug device called NeuroCuple™ to see if it can reduce pain and the need for opioid painkillers after a cesarean delivery. About 180 women having a C-section will be randomly assigned to use the device, a sham device, or standard care. The goal is to find a…

This study tests whether adding a nerve block to a standard steroid injection provides better pain relief for people with frozen shoulder (adhesive capsulitis). About 50 adults aged 41-65 who have not improved with basic care will be randomly assigned to receive either the combin…

This study tests whether an ultrasound-guided nerve block can reduce pain and the need for strong painkillers after middle ear surgery. About 56 adults having elective ear surgery will either receive the block or standard care. The goal is to see if this approach leads to less op…

This study looks at whether a high-dose nicotine patch placed on the skin before and after chest surgery can reduce pain and the need for strong painkillers in male smokers who have stopped smoking temporarily. About 80 men aged 18-75 who smoke regularly and are having lung surge…

This study tests whether a numbing injection called a TAP block can reduce pain and improve satisfaction for 100 adults undergoing heart procedures like angiography or stent placement through the groin. The block targets nerves that supply feeling to the groin area. Researchers w…

This study tests whether numbing the nerves in the upper and lower jaw before surgery can lower pain and the need for rescue painkillers after the operation. About 60 adults having jaw surgery will take part. The approach aims to make recovery more comfortable and reduce reliance…

This study tests whether using a virtual reality headset during a scheduled cesarean section can help reduce pain and anxiety. Twenty women will use VR from admission through recovery. Researchers will measure how many accept the headset and track their pain and anxiety levels.

This study tests if a long-acting painkiller (liposomal bupivacaine) works better than a standard one (ropivacaine) for pain after open upper abdominal surgery. About 146 adults having this surgery will receive one of the two drugs injected into the belly lining before the wound …

This study compares two ways to decide when surgery patients need extra pain medicine. One method uses a standard pain score, while the other also considers how much pain limits movement. The goal is to give painkillers only when truly needed, reducing overtreatment. About 76 adu…

This study tests if a long-lasting painkiller called Exparel can better control pain and reduce the need for strong narcotic pain pills in children and teens after knee surgery. About 100 participants aged 13 and older will receive either Exparel plus a standard painkiller or the…

This study looks at two common ways to give morphine for pain after a planned C-section: injecting it into the spinal fluid or into the space around the spinal cord. Researchers want to find out which method provides better pain control with fewer side effects. About 120 women ha…

This study tests if a special nerve block (SPSIPB) can reduce pain and the need for strong painkillers after minimally invasive heart surgery. Sixty adults having heart bypass surgery will be split into two groups: one gets the nerve block plus standard pain care, the other gets …

This study tests whether adding dexmedetomidine or dexamethasone to a standard numbing medicine (bupivacaine) provides better pain relief after thyroid surgery. Sixty adults having their thyroid removed will receive one of the two combinations via a nerve block. The goal is to se…

This study tests whether a special nerve block (PENG block) given before hip replacement surgery can help patients have less pain, use fewer strong painkillers, and get out of bed and walk sooner. The study will include 60 adults between 40 and 85 years old who are having hip rep…

This study tests whether giving a single dose of paracetamol or ibuprofen before nose surgery can reduce the need for stronger opioid painkillers during and after the operation. It involves 54 adults undergoing septorhinoplasty. The goal is to find a safer way to manage pain and …

This study looks at different ways to manage pain for adults with broken bones or dislocations in the emergency room. Researchers want to find which method gives the best pain relief and makes patients most satisfied. About 200 adults will take part, and their pain and satisfacti…

This early-phase study aims to understand how a device that stimulates nerves in the ear (tAN) reduces pain. Researchers will test if the pain relief comes from the body releasing its own natural opioids. The study involves 136 healthy adults and uses a drug that blocks opioids t…

This study aims to compare how much people like (abuse potential) and how well they tolerate pain after taking low-dose buprenorphine versus a common opioid, oxycodone. 120 healthy adults aged 18-65 will receive different doses of buprenorphine, oxycodone, or placebo in separate …

This study explores whether a person's genetic makeup influences their risk of complications during and after surgery, such as nausea, vomiting, heart problems, and pain. Researchers will collect data from 20,000 adults scheduled for surgery to look for links between genes and ou…

This study compares three standard pain relief methods used after open heart surgery: IV pain medicine, an epidural, and a nerve block. The goal is to see which method reduces the chance of long-term pain three months after surgery. Researchers will follow 90 adults and track the…

This study is observing 5,000 adults having elective surgery to see if their genes influence how much pain they feel afterward. Researchers will also look at other factors like medication use and recovery after one year. The goal is to better understand why some people have more …

This study follows 2000 adults who are having weight-loss surgery to understand how pain and daily activities change afterward. Researchers will ask patients about their pain, side effects, and ability to do everyday tasks. The goal is to learn what influences pain after surgery,…