Analgesia
Clinical trials for Analgesia explained in plain language.
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Two strong painkillers go Head-to-Head in the ambulance
Symptom relief Stopped earlyParamedics in the Netherlands often treat severe pain after trauma with either fentanyl or esketamine, but no one knows if one works as well as the other or if a nasal spray works as well as an IV. The FORE-PAIN trial randomly assigns adults with acute traumatic pain to one of fo…
Matched conditions: ANALGESIA
Phase 3 • Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) • Aim: Symptom relief
Last updated Sep 17, 2026 00:00 UTC
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New knee pain block fails to prove extra benefit in small trial
Symptom relief Stopped earlyThis study looked at whether adding an iPACK nerve block to standard pain treatments (adductor canal block and local injections) helps people feel less pain and recover faster after total knee replacement. Only 10 people were enrolled before the study was stopped early. The goal …
Matched conditions: ANALGESIA
Phase 4 • Sponsor: University of Calgary • Aim: Symptom relief
Last updated Jun 27, 2026 13:01 UTC
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Pain relief combo falls short: early trial halted
Symptom relief Stopped earlyThis study tested whether adding baclofen (a muscle relaxant) to buprenorphine (a painkiller) could improve pain relief in 19 healthy volunteers. Participants received either a placebo or baclofen alongside buprenorphine and then underwent heat-based pain tests. The trial was ter…
Matched conditions: ANALGESIA
Phase 2/3 • Sponsor: University of Alabama at Birmingham • Aim: Symptom relief
Last updated Jun 27, 2026 08:08 UTC