ANALGESIA

This study looked at whether adding dexmedetomidine to standard pain relief after cancer surgery helps elderly patients (65-89 years) live longer. Researchers think it might reduce stress and inflammation, improving immune function. 1500 participants were followed for survival an…

This study tested whether a numbing injection near the hip (femoral nerve block) works better than IV fentanyl for pain from a broken hip in the emergency room. 104 adults with hip fractures took part. The goal was to see which method provides faster and more effective pain relie…

This study tested two types of nerve blocks to control pain after breast surgery. One hundred adults received either a serratus posterior superior intercostal plane block or a pectoral nerve (PECS II) block. Researchers measured how much morphine patients needed and how well they…

This study tested whether an ultrasound-guided TAP block (a type of nerve block in the belly area) can reduce pain and improve stability during a minimally invasive heart valve replacement called TAVI. Fifty adults having elective TAVI took part. The goal was to see if the block …

This study tested whether adding a painkiller called nefopam to standard care could reduce the amount of strong opioids needed for sedating critically ill patients on breathing machines. 60 adults participated in a double-blind trial. The goal was to see if nefopam could help pat…

This study tested two types of nerve blocks—transmuscular quadratus lumborum block and lumbar plexus block—to see which one controls pain better after thigh lift surgery. 42 adults having elective spiral thighplasty took part. Researchers measured pain scores, how soon patients n…

This study tested two different ultrasound-guided nerve blocks to see which provides better pain relief after elective neck surgery. 102 adults were randomly assigned to receive either an inter-semispinal fascial plane block or an erector spinae plane block. The main goal was to …

This study tested two different non-opioid pain medicines given continuously during gallbladder surgery to see which one controls pain better and reduces the need for opioids. 64 adults having laparoscopic gallbladder removal took part. The goal was to find a safer way to manage …

This study looked at whether a specific nerve block (erector spinae plane block) can reduce pain and the need for painkillers after robotic-assisted partial kidney removal. 46 adults aged 18-70 were randomly assigned to receive either the nerve block with bupivacaine or no block.…

This study tested two types of nerve blocks to manage pain after cancer surgery on the upper belly. 70 adults received either an erector spinae plane block or an external oblique intercostal plane block before surgery. The goal was to see which block reduced the need for morphine…

This study looked at different nerve blocks to manage pain after breast cancer surgery. 188 women took part, and researchers measured how long it took before they needed rescue pain medicine. The goal was to find which block provides longer-lasting pain relief.

This study looked at 75 women who had planned cesarean deliveries to see if different pain management methods affect how soon and how exclusively they breastfeed. Researchers compared TAP blocks (a type of abdominal wall injection) with other pain relief options. The goal was to …

This study tested three different pain-relief methods in 75 children aged 2 to 7 years having hernia surgery. The goal was to see which method provides the best pain control after the operation. Researchers measured pain scores and how much extra pain medicine was needed. The res…

This study tested three different nerve blocks (TTPB, MTPB, and ESPB) to see which provides the best pain relief after thoracoscopic sympathectomy, a type of chest surgery. Sixty adults were randomly assigned to one of the three blocks. The main goal was to measure how long it to…

This study tested two different nerve block techniques to control pain after shoulder arthroscopic surgery. Fifty adults were randomly assigned to receive either a serratus posterior superior intercostal plane block or a combination of suprascapular and axillary nerve blocks. The…

This study tested whether a PECS nerve block, given before surgery, could lower the amount of opioids needed and improve pain control in women undergoing breast cancer surgery. Seventy women took part, and the approach aimed to reduce pain and increase satisfaction. The results h…

This study compared two ultrasound-guided nerve blocks—erector spinae plane (ESP) block and rhomboid intercostal block (RIB)—for managing pain after breast surgery. 84 patients undergoing unilateral breast surgery received one of the two blocks, and researchers measured how much …

This study tested whether a 15 mg dose of the painkiller ketorolac works as well as a 60 mg dose for treating sudden muscle pain in a military emergency department. 110 adults with acute muscle pain received one of the two doses. The goal was to see if the lower dose provides sim…

This study tested whether adding dexmedetomidine to the standard painkiller fentanyl could reduce the amount of fentanyl needed in full-term newborns on breathing machines. Forty infants were enrolled. The goal was to see if the combination could keep babies comfortable with less…

This study tested whether adding dexmedetomidine, a mild sedative, to standard pain relief could lower the risk of delirium (sudden confusion) in older adults after cancer surgery. Delirium is common in elderly patients and can lead to worse recovery. The trial involved 1,500 pat…

This study looked at whether adding a low-dose ketamine drip to standard pain medicine helps people who just had knee replacement surgery. One hundred adults were split into two groups: one got usual pain care, the other got usual care plus ketamine through a pump they could cont…

This study tested three different numbing injections (transversus thoracic muscle plane block, erector spinae plane block, and paravertebral block) in 60 adults having video-assisted chest surgery. The goal was to see which method delays the need for extra pain medicine and reduc…

This study looked at two different methods to control pain after lower back surgery. One method uses a nerve block (erector spinae plane block), and the other uses a drug called ketamine along with other pain medicines. The goal was to see which approach helps patients recover be…

This study tested a new pain management plan for people having total knee replacement. All 116 participants received a long-acting numbing medication (HTX-011) along with other non-opioid pain relievers, avoiding strong opioid drugs. The goal was to see if this approach could eff…

This study tested whether adding ketamine or magnesium sulfate to a standard numbing injection (nerve block) could better control pain after breast cancer surgery. Sixty adults undergoing mastectomy received one of the two add-ons, and researchers measured how much extra morphine…

This study tested two methods to reduce pain after a planned C-section: injecting local anesthetic into the belly and wound, versus using morphine in the spine. 46 women participated, and researchers measured how much extra pain medicine they needed in the first 24 hours. The goa…

This study tested whether a special nerve block (recto-intercostal fascial plane block) can reduce pain after epigastric hernia repair. Forty adults having elective surgery received either the block or standard care. The goal was to see if the block delays the need for rescue mor…

This study looked at 71 women having open surgery for gynecologic cancer. It compared two ways to control pain after surgery: an epidural block and a newer erector spinae plane block. Researchers measured pain scores, how much opioid pain medicine was needed, and how quickly pati…

This study looked at whether taking ibuprofen for eight days after hip or knee replacement is safe. About 2904 adults took part. Researchers tracked serious problems like heart attack, stroke, bleeding, or kidney failure for 90 days after surgery.

This study tested a non-invasive device called ANI that measures heart rate patterns to assess comfort in 20 non-communicating patients receiving end-of-life palliative care. The goal was to see if the ANI could reliably detect pain or stress during routine care, compared to a st…

This study tested whether a special nerve block called the erector spinae plane (ESP) block can improve pain relief after flexible ureteroscopy (URS) surgery for kidney stones. Seventy adults were randomly assigned to receive either the ESP block plus standard pain care or standa…

This study tested two different nerve block techniques to manage pain after breast surgery. 62 adults having a mastectomy were randomly assigned to receive one of the two blocks. Researchers measured pain scores and painkiller use over 24 hours to see which method worked better.

This study looked at how satisfied patients were with their pain control after outpatient ear, nose, and throat (ENT) procedures. Researchers compared patients who received opioid painkillers to those who received non-opioid options. The goal was to see if non-opioid pain relief …

This study looked at how two pain medicines, lidocaine (given through a vein) and ropivacaine (given through a small tube in the back), affect each other's levels in the blood during major abdominal surgery. 51 adults having open abdominal surgery took part. The goal was to under…

This study looked at how well BD NRFit spinal needles and syringes work in real-world medical settings. 161 patients who needed a spinal procedure (like an epidural or spinal tap) were included. The main goal was to see if the needles and syringes performed correctly and safely, …

This study looked at 150 ICU patients on breathing machines to see if adding a brain activity monitor (pEEG) to standard sedation checks could reduce confusion (delirium), time on the ventilator, and long-term problems after ICU. Researchers compared patients who got both the bra…

This study used brain imaging to understand how a low dose of the sedative dexmedetomidine reduces pain. Seventeen healthy adults received the drug while researchers measured changes in brain fluid flow. The goal was to learn more about the drug's pain-relieving effects, not to t…