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New Non-Opioid painkiller shows promise for knee surgery patients

NCT ID NCT03974932

First seen Mar 16, 2026 · Last updated Jun 16, 2026 · Updated 15 times

Summary

This study tested a new non-opioid pain medicine called HTX-011 in 116 people having knee replacement surgery. Everyone received the medicine as part of a pain plan that did not include opioids. The goal was to see how well it controlled pain after surgery. The study is complete, and results may help reduce the need for strong opioid painkillers.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Endeavor Clinical Trials, LLC.

    San Antonio, Texas, 78229, United States

  • First Surgical Hospital

    Bellaire, Texas, 77401, United States

  • Helen Keller Hospital

    Sheffield, Alabama, 35660, United States

  • Midwest Clinical Research Center, LLC

    Dayton, Ohio, 45417, United States

  • Phoenix Clinical Research, LLC

    Tamarac, Florida, 33321, United States

  • Plano Surgical Hospital

    Plano, Texas, 75093, United States

Conditions

The condition(s) this trial relates to.

agnosia pain agnosia Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.