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New hope for knee pain: cooled radiofrequency targets tested

NCT ID NCT05363241

Symptom relief Sponsor: Universidade Federal de Alfenas Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed study tested two versions of a cooled radiofrequency procedure to relieve chronic knee pain from osteoarthritis. Ten adults with moderate to severe pain received either the standard or a revised nerve-targeting technique. Researchers measured pain, knee function, quality of life, and side effects over six months to see which approach works better.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
cooled radiofrequency procedure
What this could lead to
If successful, this could point toward a more effective, minimally invasive pain relief option for people with knee osteoarthritis who cannot have surgery.
What could go wrong
This is a very small, early study with only 10 participants, so results may not apply to everyone. The procedure carries risks like temporary numbness or discomfort.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

10 people

The number who actually took part.

Started

Sep 2022

Finished

Jul 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients of both genders aged 40 years or older; * Patients diagnosed with knee OA through X-rays and MRI (Alhback classification 2 or 3); * Patients with chronic knee pain for more than 3 months at the time of inclusion; * Patients with moderate to severe knee pain (score of 5 or more on the visual analog scale) * Patients who are literate, can read and write, and have a good understanding of written and verbal language. Exclusion Criteria: * Patients younger than 40 years old, even if diagnosed with knee OA; * Patients not diagnosed through imaging tests with OA; * Patients who have undergone previous knee surgery in the last 3 months before inclusion; * Patients who have received intra-articular corticosteroid injection in the last 3 months before inclusion; * Patients with uncontrolled neurological or psychiatric disease; * Patients with uncontrolled diabetes; * Pregnant patients; * Cancer diagnosed patients; * Patients with lumbar radiculopathy; * Patients on continuous anticoagulant therapy; * Patients who are not literate, can not read and write, and have not a good understanding of written and verbal language.

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Conditions

The condition(s) this trial relates to.

agnosia Chronic Pain chronic pain syndrome osteoarthritis, knee pain agnosia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Analgesia Osteoarthritis, knee Pain, chronic

Contacts and locations

Locations

  • Universidade Federal de Alfenas

    Alfenas, Minas Gerais, Brazil

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