Could ketamine be the key to better pain relief after knee surgery?
NCT ID NCT07059429
First seen Oct 31, 2025 · Last updated Jun 19, 2026 · Updated 30 times
Summary
This study looked at whether adding a low-dose ketamine infusion to standard pain medication can help people who just had knee replacement surgery. One hundred adults were randomly assigned to get either standard pain relief alone or standard relief plus ketamine through a patient-controlled pump. Researchers measured how much opioid painkiller they needed and how much pain they felt in the first 24 hours after surgery.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Pirogov National Medical and Surgical Center
Moscow, 105203, Russia
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
ketamine
What this could lead to
If it works, this could offer a way to reduce opioid use and improve pain control after knee replacement surgery.
What could go wrong
This is a small, completed study with no phase designation, so results may not be conclusive or widely applicable. Ketamine can cause side effects like nausea or neuropsychiatric reactions.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.