ANALGESIA

This study tests whether using a virtual reality headset during a scheduled cesarean section can help reduce pain and anxiety. Twenty women will be offered the headset at different stages of care, from admission to after birth. Researchers will measure how many accept and use it,…

This study tests whether adding an extra nerve block (IPACK) to a standard one (adductor canal block) can better control pain and reduce opioid use after knee realignment surgery. About 100 adults undergoing specific knee osteotomies will be randomly assigned to receive either th…

This study compares three doses of a medicine called dexmedetomidine, added to the numbing drugs used for nerve blocks during arm surgery. The goal is to see if a higher dose keeps the arm numb and pain-free for longer. About 69 adults having surgery below the elbow will take par…

This study tests whether a numbing injection (TAP block) given before heart procedures done through the groin can reduce pain and improve patient and doctor satisfaction. About 100 adults having planned heart catheterization or stent placement will be randomly assigned to receive…

This study compares giving a single dose of paracetamol or ibuprofen before septorhinoplasty (nose surgery) to see if it reduces the amount of opioid painkillers needed during and after surgery. Researchers will track total opioid use, pain scores, and recovery quality in 54 adul…

This study compares two types of nerve blocks (ESPB and PIFB) to see which one provides better pain relief and helps patients recover their breathing after open-heart surgery. About 80 adults having their first heart surgery will take part. The goal is to find the best way to man…

This study tests whether a nerve block (injecting numbing medicine near a nerve in the ear) can reduce pain and the need for strong painkillers after middle ear surgery. About 56 adults having ear surgery will be randomly assigned to get the nerve block or standard care. The main…

This study tests whether a special nerve block (SPSIPB) can reduce pain and the need for strong painkillers after minimally invasive heart surgery. Sixty adults having heart bypass surgery will be randomly assigned to receive either the nerve block plus standard pain care or stan…

This study compares two ways of giving morphine after a planned C-section: through a shot in the spine (intrathecal) or through a small tube near the spine (epidural). The goal is to find which method provides better pain relief with fewer side effects like nausea or itching. Abo…

This study tests if a long-lasting painkiller called Exparel can reduce pain and the need for strong narcotic pain pills in children aged 13 and older after knee surgery. About 100 participants will receive either Exparel plus a standard painkiller or the standard painkiller alon…

This study compares two types of anesthesia for children having cleft lip or palate surgery: one using opioids and one without opioids. The goal is to see if the opioid-free approach can control pain and reduce agitation just as well, while causing fewer side effects like nausea …

This study looks at whether a lower dose (15mg) of the painkiller ketorolac works as well as a higher dose (30mg) for people with kidney stone pain in the emergency room. About 86 adults under 65 with moderate to severe pain will be enrolled. The main goal is to see how much pain…

This study tests a device called NeuroCuple™ that uses no drugs to manage pain after cesarean delivery. Researchers want to see if it reduces pain and the need for opioid painkillers. The study will include 180 women having a C-section. Half will get the real device, and the othe…

This study tests whether a nerve block given before surgery (TAP block) works as well as numbing medicine injected into the wound by the surgeon for controlling pain after gynecologic cancer surgery. About 80 women having surgery through a vertical belly cut will take part. The g…

This study tests if a long-acting painkiller (liposomal bupivacaine) works better than a standard one (ropivacaine) for pain after upper abdominal surgery. About 146 adults having open surgery will receive one of the two drugs injected into the belly lining before the incision is…

This study tests whether a new pain scale that considers both pain level and ability to move can better guide when to give extra painkillers after surgery. About 76 adults having scheduled surgery will be randomly assigned to receive rescue pain medication based on either the sta…

This study tests whether adding a nerve block to a steroid injection works better than a steroid injection alone for people with frozen shoulder (adhesive capsulitis). About 50 adults aged 41-65 with persistent shoulder pain will be enrolled. The goal is to see which approach pro…

This study is testing whether a special nerve block (PENG block) given before hip replacement surgery can help reduce pain, lower the need for strong painkillers, and help patients get moving sooner. About 60 adults aged 40-85 who are having hip replacement will take part. The go…

This study looks at whether numbing the upper and lower jaw nerves before surgery can lower pain and the need for extra pain medicine after jaw surgery. About 60 adults having planned jaw surgery will take part. The goal is to see if this nerve block helps control pain better tha…

This study looks at whether a high-dose nicotine patch placed on the skin before and after chest surgery can help male smokers who have quit temporarily feel less pain and need fewer opioids. About 80 men aged 18-75 who smoke regularly will take part. The goal is to find a safer …

This study compares a newer type of nerve block (serratus plane block) to standard local anesthesia for pain control during chest tube placement in intensive care patients. About 70 awake, non-intubated adults will be enrolled. The goal is to see if the nerve block reduces pain s…

This study compares two types of nerve blocks to see which provides better pain relief after total hip replacement. Fifty adults having hip surgery will receive one of the two blocks. Researchers will measure pain scores and how much extra morphine is needed. The goal is to impro…

This study tests whether adding ketorolac (an anti-inflammatory) to the standard lidocaine numbing shot reduces pain during office hysteroscopy, a procedure to look inside the uterus. About 60 women with abnormal bleeding will be randomly assigned to get either the combined numbi…

This study compares two medicines, dexmedetomidine and dexamethasone, added to a standard numbing drug for a neck nerve block in people having their thyroid removed. The goal is to see which combination provides better pain relief after surgery. Sixty adults will take part in thi…

This observational study looks at different ways to manage pain and sedation for adults with broken bones or dislocations in the emergency department. Researchers will compare standard care with various sedation and pain relief methods to see which one patients prefer and which p…

This study looks at how a device that gently stimulates nerves in the ear might relieve pain. Researchers want to know if it works by making the body release its own natural painkillers (opioids). They will test this in 136 healthy adults by giving some a drug that blocks opioids…

This study follows 2000 adults having planned bariatric surgery to learn what influences their pain and daily functioning afterward. Researchers will track pain levels, medication use, and long-term discomfort using patient questionnaires. The goal is to identify factors that lea…

This study explores whether a person's genetic makeup influences how they recover from surgery. Researchers will track 20,000 adults having planned operations, looking at complications like nausea, vomiting, and pain. The goal is to identify genetic factors that could help predic…

This study watches 90 adults having open heart surgery to compare three standard pain relief methods: IV drugs, an epidural, or a nerve block. The main goal is to see which method best prevents chronic pain 3 months later. Researchers will also track pain levels, recovery speed, …

This study looks at how a person's genes and other factors influence pain after surgery. Researchers will follow 5,000 adults having planned operations to see which genetic variations are linked to pain levels and painkiller use. The goal is to better understand and personalize p…

This study tests whether low-dose buccal buprenorphine (a film placed in the cheek) can provide pain relief similar to a standard dose of oxycodone but with less potential for abuse. 120 healthy adults will receive different doses of buprenorphine, oxycodone, or placebo in separa…

This study looks at how painkillers and sedatives are given to patients on ECMO, a life support machine for severe heart or lung failure. Researchers will first review current sedation practices in UK hospitals. Then, with help from patients, families, and staff, they will design…

This study looks at how the brain's natural pain-fighting systems relate to pain relief from a common back injection called a medial branch block. About 40 adults with chronic low back pain will take part. Researchers will measure pain levels before and after the injection to und…

This study looks at whether giving fentanyl (a strong painkiller) through a mist sprayed on the face or into the nose works well for emergency pain relief. Twenty healthy adults will try both methods to see how much medicine gets into the body and how comfortable it is. The goal …