ANALGESIA

This study tests whether numbing the nerves in the upper and lower jaw before surgery can reduce pain and the need for rescue painkillers after the procedure. About 60 adults having elective jaw surgery will be randomly assigned to receive either the nerve block or a placebo. The…

This study tests whether a special nerve block (PENG block) given before hip replacement surgery can reduce pain, lower the need for strong painkillers, and help patients get up and walk sooner. About 60 adults aged 40-85 having hip replacement will be enrolled. The goal is to se…

This study tests a device called NeuroCuple™, which uses no medication, to manage pain after cesarean delivery. Researchers will compare it to a sham device and standard care in 180 women. The goal is to see if it reduces pain and the need for opioid painkillers.

This study tests whether adding a shoulder nerve block to a standard steroid injection provides better pain relief for people with frozen shoulder (adhesive capsulitis) than the steroid injection alone. About 50 adults aged 41-65 with persistent shoulder pain and stiffness will t…

This study tests whether an opioid-free anesthesia method can control pain and agitation as well as or better than standard opioid-based anesthesia in 90 children aged 3 months to 7 years undergoing cleft lip or palate repair. The opioid-free group receives ketamine and dexmedeto…

This study tests whether giving a single dose of paracetamol or ibuprofen before nose surgery (septorhinoplasty) can reduce the need for stronger opioid painkillers during and after the operation. Researchers will enroll 54 adults and measure total opioid use, pain scores, and re…

This study tests whether a 15mg or 30mg dose of the painkiller ketorolac provides longer pain relief for people with kidney stone pain in the emergency department. About 86 adults under 65 with moderate to severe pain will receive one dose, and their pain levels will be tracked o…

This study looks at whether a high-dose nicotine patch, applied before and after chest surgery, can help reduce pain and the need for strong painkillers in male smokers who have temporarily quit. About 80 men who smoke regularly and are having lung surgery will take part. The goa…

This study tests if a long-acting painkiller (liposomal bupivacaine) works better than a standard one (ropivacaine) for pain after open upper abdominal surgery. About 146 adults having this surgery will receive one of the two drugs injected into the belly lining before the incisi…

This study compares two types of nerve blocks (ESPB and PIFB) to see which one provides better pain relief and helps patients breathe easier after open-heart surgery. About 80 adults having their first heart surgery will take part. The main goal is to measure how much pain medici…

This study is looking at whether a person's genetic makeup influences how they recover from surgery. Researchers will track 20,000 adults to see if certain genes are linked to complications like nausea, pain, or heart problems after an operation. The goal is to better understand …

This study aims to understand why some people feel more pain after surgery than others. Researchers will analyze genetic and non-genetic factors in 5,000 adults undergoing elective surgery. The goal is to improve pain management by identifying factors that influence pain and reco…

This study looks at whether a gentle electrical stimulation on the ear (called tAN) can help the body release its own natural pain-relieving chemicals (endogenous opioids). Researchers will test this in 136 healthy adults by measuring pain tolerance after the stimulation, with an…

This study aims to see if low-dose buprenorphine, a partial opioid, is less addictive than oxycodone while providing similar pain relief. Healthy volunteers will receive different doses of buprenorphine, oxycodone, or a placebo in separate sessions. Researchers will measure pain …