ANALGESIA

This study looked at whether adding dexmedetomidine to standard pain relief after cancer surgery helps elderly patients (65-90 years old) live longer. The idea is that this drug may reduce stress, inflammation, and confusion, possibly improving immune function and long-term outco…

This study tested whether a non-opioid pain regimen, including a long-acting numbing shot (HTX-011) and standard pain relievers like ibuprofen and acetaminophen, could help people avoid opioids after hernia surgery. About 209 adults scheduled for open inguinal hernia repair took …

This study tested whether giving the sedative dexmedetomidine during lung surgery (without a breathing tube) can reduce coughing and pain. 144 adults took part. Researchers measured cough severity and the need for other painkillers. The goal is to make recovery smoother and more …

This study compared two types of nerve blocks for pain control after breast surgery: the serratus posterior superior intercostal plane block and the PECS II block. One hundred adults aged 21 to 70 were enrolled. Researchers measured how much morphine patients needed in the first …

This study looked at 120 boys aged 4 months to 12 years having urogenital surgery. It compared an opioid-free caudal block (using bupivacaine) with an opioid-supplemented penile nerve block (using fentanyl) to see which provides better pain control and less post-surgery delirium.…

This study compared two pain relief methods for people undergoing lower back decompression surgery. One group received a nerve block (erector spinae plane block), while the other received ketamine through an IV. Researchers measured how well patients recovered using a quality-of-…

This study tested three different pain-blocking methods in 75 children aged 2 to 7 having hernia surgery. The goal was to see which method works best to keep kids comfortable after the operation. Researchers measured pain levels, how much extra pain medicine was needed, and any s…

This study compared two types of nerve blocks (Serratus Anterior Plane Block and Serratus Posterior Superior Intercostal Plane Block) to see which one provides better pain relief after breast surgery. 62 adults having a mastectomy were included. The goal was to reduce pain and th…

This study tested two types of nerve blocks to manage pain after cancer surgery on the upper belly. 70 adults having liver or kidney surgery received either an erector spinae plane block or an external oblique intercostal plane block. The main goal was to see which block reduced …

This completed study tested whether an ultrasound-guided nerve block (TAP block) provides better pain relief after C-section than standard pain medicine. 100 women aged 20-50 who had a C-section took part. Researchers measured pain scores to see which method worked better.

This study looked at whether adding a low-dose ketamine infusion to standard pain medication can help people who just had knee replacement surgery. One hundred adults were randomly assigned to get either standard pain relief alone or standard relief plus ketamine through a patien…

This study tested whether a nerve block called an erector spinae plane block can reduce pain and the need for painkillers after robotic-assisted partial kidney removal. Forty-six adults aged 18-70 were randomly assigned to receive either the nerve block or standard care. The goal…

This study compared two types of nerve blocks (ISPB and ESPB) to see which provides better pain relief for adults undergoing elective neck surgery. A total of 102 participants were randomly assigned to receive one of the two blocks. The main goal was to measure how much opioid pa…

This study tested whether an ultrasound-guided PECS nerve block could reduce opioid use and improve pain control in 70 women undergoing breast cancer surgery. Participants received either the nerve block or standard care. The goal was to see if the block leads to less pain, less …

This study tested two drugs, dexmedetomidine and lidocaine, given continuously during gallbladder surgery to control pain and reduce the need for strong opioids. 64 adults having laparoscopic cholecystectomy took part. The goal was to see which drug provides better pain relief an…

This study looked at whether adding a sedative called dexmedetomidine to standard pain relief can prevent delirium (sudden confusion) in older adults after cancer surgery. Delirium is common in elderly patients and can lead to worse recovery. The trial involved 1,500 patients age…

This study compared two methods of pain relief after hip replacement surgery: a newer technique called erector spinae plane block (ESPB) and the standard epidural. 60 adults having hip replacement took part. Researchers measured pain levels, opioid use, muscle strength, and walki…

This study looked at two different nerve blocks to control pain after thigh lift surgery. 42 adults received either a quadratus lumborum block or a lumbar plexus block. Researchers measured pain levels and how long it took for patients to need extra pain medicine.

This study tested whether a lower dose (15 mg) of the painkiller ketorolac works as well as a higher dose (60 mg) for treating sudden muscle pain in a military emergency department. 110 adults with acute muscle pain received one injection of either dose. The results showed that t…

This study looked at different ways to control pain after breast cancer surgery. 188 women took part to see which method helped them go longer without needing extra pain medicine. The goal was to improve comfort and recovery after surgery.

This study tested if a local pain injection (liposomal bupivacaine) works as well as an epidural for pain relief after open gynecologic surgery. 106 adults participated. The goal was to see if the injection could provide similar pain control and recovery while being more cost-eff…

This study tested a new non-opioid pain medicine called HTX-011 in 116 people having knee replacement surgery. Everyone received the medicine as part of a pain plan that did not include opioids. The goal was to see how well it controlled pain after surgery. The study is complete,…

This study tested a non-invasive heart monitor (ANI) to see if it can assess comfort in 20 non-communicating patients at the end of life. The monitor measures heart rate changes to detect stress or pain. Researchers compared ANI readings to nurses' pain scores during a painful pr…

This study tested whether adding ketamine or magnesium sulfate to a standard nerve block could reduce pain and the need for morphine after breast cancer surgery. Sixty adults undergoing mastectomy received one of the two add-ons alongside the numbing medication. The main goal was…

This study tested whether a special nerve block called the erector spinae plane (ESP) block can improve pain control after flexible ureteroscopy, a common surgery for kidney stones. 70 adults were randomly assigned to receive either the ESP block plus standard pain care or standa…

This study tested a procedure called cooled radiofrequency to treat chronic knee pain from osteoarthritis. It compared the standard nerve targets with newer, more complete targets. Ten adults with moderate to severe knee pain were followed for six months to see which approach wor…

This study looked at whether a specific nerve block (recto-intercostal fascial plane block) can reduce pain after epigastric hernia repair. Forty adults having elective surgery received either the block or standard care. The goal was to see if the block delayed the need for extra…

This study tested three different numbing injections (nerve blocks) to see which one provides the best pain relief after a type of chest surgery called thoracoscopic sympathectomy. Sixty adults took part, and researchers measured how long it took before they needed morphine for p…

This study compared two types of nerve blocks (ESP and RIB) to see which one provides better pain relief after breast surgery. 84 patients received one of the blocks, and researchers measured how much morphine they needed and their pain scores. The goal was to find a more effecti…

This study looked at whether adding nalbuphine to a standard spinal anesthetic (levobupivacaine) could reduce the need for morphine after total hip replacement. Sixty adults were randomly assigned to receive either the standard anesthetic alone or with nalbuphine. Researchers mea…

This study tested whether adding dexmedetomidine to fentanyl could reduce the amount of fentanyl needed for pain and sedation in full-term newborns on breathing machines. Forty newborns participated. The goal was to see if the combination could safely lower fentanyl doses while s…

This study tested three different nerve blocks to control pain after video-assisted chest surgery. Sixty adults received one of the blocks, and researchers measured how long they could go before needing morphine. The goal is to find the best way to reduce pain and the need for st…

This study tested whether an ultrasound-guided belly muscle nerve block (TAP block) can reduce pain and movement during a minimally invasive heart valve replacement (TAVI). Fifty adults having elective TAVI received either the block plus sedation or sedation alone. The goal was t…

This study looked at whether taking ibuprofen for eight days after hip or knee replacement surgery is safe. Over 2,900 adults were followed for 90 days to track serious problems like heart attack, stroke, bleeding, or kidney failure. The goal was to help doctors decide if ibuprof…

This study tested whether adding a painkiller called nefopam to standard care could lower the amount of strong opioids needed by ICU patients on breathing machines. 60 adults took part in a double-blind trial where some received nefopam and others standard care. The goal was to s…

This study looked at whether taking aspirin and ketamine together by mouth can help adults whose depression hasn't improved with standard antidepressants. Fifteen people with treatment-resistant depression took the combination for one week. Researchers measured changes in depress…

This study looked at two ways to control pain after open gynecologic cancer surgery: an epidural block and a newer erector spinae plane block. Researchers measured pain scores, opioid use, and how soon patients could move after surgery. The goal was to see if the newer block work…

This study tested two different nerve block techniques to control pain after shoulder arthroscopic surgery. Fifty adults were randomly assigned to receive either a serratus posterior superior intercostal plane block or a combination of suprascapular and axillary nerve blocks. The…

This study tested whether a numbing injection near the hip (femoral nerve block) works better than IV fentanyl for pain from a broken hip in the emergency room. 104 adults with hip fractures took part. The goal was to see which method provides faster and more effective pain relie…

This study tested two methods to reduce pain after a planned C-section: injecting local anesthetic into the belly and wound, versus using morphine in the spine. 46 women participated, and researchers measured how much extra pain medicine they needed in the first 24 hours. The goa…

This study tested how well BD NRFit spinal needles and syringes work in real-world medical settings. A total of 161 patients receiving anesthesia or pain relief procedures were included. Researchers measured successful needle placement, syringe function, and safety issues like he…

This study looked at how satisfied patients were with their pain control after outpatient ear, nose, and throat (ENT) procedures. Researchers compared those who received opioid pain medication to those who received non-opioid alternatives. 160 adults participated, and the main go…

This study looked at how different pain relief methods after planned C-sections affect how soon and how exclusively mothers breastfeed. Researchers followed 75 women who had elective C-sections with spinal anesthesia and compared pain management approaches. The goal was to see if…

This study looked at whether a tool called the Surgical Pleth Index (SPI), which measures stress during surgery, can predict how much pain a person will feel after waking up from a brain operation. 52 adults having craniotomy were monitored, and their pain scores and painkiller u…

This study looked at how much lidocaine and ropivacaine stay in the blood when both are used for pain control during major abdominal surgery. It involved 51 adults having open abdominal surgery. The goal was to understand if combining these drugs is safe and how their levels chan…

This study looked at whether adding a brain wave monitor (pEEG) to standard sedation checks helps reduce delirium and time on a breathing machine in ICU patients. Researchers followed 150 adults on ventilators who needed sedation. They compared those who got both the brain monito…

This study looked at how a low dose of the sedative drug dexmedetomidine affects pain signals in the brain. Researchers used brain scans to measure changes in fluid flow. 17 healthy adults took part. The goal was to understand the drug's pain-relieving effects, not to test a new …