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Opioid-Free pain relief after surgery: just as good?

NCT ID NCT04976387

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at how satisfied patients were with their pain control after outpatient ear, nose, and throat (ENT) procedures. Researchers compared those who received opioid pain medication to those who received non-opioid alternatives. 160 adults participated, and the main goal was to see if non-opioid options could provide similar satisfaction. The findings could help reduce unnecessary opioid prescriptions.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
opioid and non-opioid pain medications
What this could lead to
If successful, this could show that non-opioid pain relief is just as satisfying for patients, potentially reducing opioid use after common surgeries.
What could go wrong
This is a completed, small study (160 people) focused on patient perception, not on measuring actual pain relief or long-term outcomes. Results may not apply to all surgeries or patient groups.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

160 people

The number who actually took part.

Started

Jul 2021

Finished

May 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Study population is comprised of outpatients undergoing specific outpatient surgery procedures as outline in the inclusion criteria, at an LLUHS associated surgical facility.

Ages

18 to 89 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients between the ages of 18 and 89 years of age * Patients undergoing the following outpatient procedures: * total or partial thyroidectomy * parathyroidectomy * parotidectomy * submandibular gland excision * neck mass excision * facial mass excision * MOHS defect repair * excision of cutaneous lesions * Other surgeries may qualify and will be assessed on a case by case basis. Exclusion Criteria: * Patients under 18 years old or older than 89 years old * Those allergic to Hydrocodone, Acetaminophen, or NSAIDS * Patients who are pregnant * Patients with chronic medical conditions including hepatic/renal disease that precludes their ability to utilize the study medications.

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Conditions

The condition(s) this trial relates to.

agnosia pain agnosia Pain, Postoperative Patient Satisfaction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Loma Linda University Health System

    Loma Linda, California, 92354, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.