Opioid-Free pain relief after surgery: just as good?
NCT ID NCT04976387
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at how satisfied patients were with their pain control after outpatient ear, nose, and throat (ENT) procedures. Researchers compared those who received opioid pain medication to those who received non-opioid alternatives. 160 adults participated, and the main goal was to see if non-opioid options could provide similar satisfaction. The findings could help reduce unnecessary opioid prescriptions.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- opioid and non-opioid pain medications
- What this could lead to
- If successful, this could show that non-opioid pain relief is just as satisfying for patients, potentially reducing opioid use after common surgeries.
- What could go wrong
- This is a completed, small study (160 people) focused on patient perception, not on measuring actual pain relief or long-term outcomes. Results may not apply to all surgeries or patient groups.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
-
160 people
The number who actually took part.
- Started
-
Jul 2021
- Finished
-
May 2023
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Study population is comprised of outpatients undergoing specific outpatient surgery procedures as outline in the inclusion criteria, at an LLUHS associated surgical facility.
- Ages
-
18 to 89 years
- Sex
-
Anyone
- Healthy volunteers
-
Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients between the ages of 18 and 89 years of age * Patients undergoing the following outpatient procedures: * total or partial thyroidectomy * parathyroidectomy * parotidectomy * submandibular gland excision * neck mass excision * facial mass excision * MOHS defect repair * excision of cutaneous lesions * Other surgeries may qualify and will be assessed on a case by case basis. Exclusion Criteria: * Patients under 18 years old or older than 89 years old * Those allergic to Hydrocodone, Acetaminophen, or NSAIDS * Patients who are pregnant * Patients with chronic medical conditions including hepatic/renal disease that precludes their ability to utilize the study medications.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Loma Linda University Health System
Loma Linda, California, 92354, United States
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