POSTOPERATIVE PAIN

This study tests a program to help people with chronic pain who take opioids before surgery reduce or stop their opioid use afterward. The program includes pain education, counseling, and a mobile app. About 210 adults will take part to see if the program improves pain management…

This study compares two regional anesthesia techniques to manage pain in 50 adults undergoing heart surgery via a chest incision. One group receives an Erector Spinae Plane Block, while the other gets a combination of Superficial Parasternal Intercostal Plane Block and Serratus A…

This study tests whether a special nerve block called the rectus-intercostal fascial plane (RIFP) block can reduce pain and the need for morphine in people who donate part of their liver. Sixty-four donors will be randomly assigned to get either the block plus standard pain medic…

This study tests whether a nerve block called the transversalis fascia plane block can reduce pain and opioid use after hand-assisted laparoscopic donor nephrectomy. Fifty living kidney donors will be randomly assigned to receive either standard anesthesia alone or standard anest…

This study tests whether an ultrasound-guided nerve block, given before lumbar spine surgery, can reduce the need for strong painkillers (opioids) afterward. Fifty adults scheduled for back surgery will be randomly assigned to receive either the nerve block plus standard pain car…

This study tests whether a robotic seal named PARO can reduce agitation, anxiety, and pain in patients recovering from abdominal surgery. 300 adults having elective visceral surgery will be randomly assigned to use PARO or not. Researchers will monitor agitation, pain, and anxiet…

This study compares two types of nerve blocks—sacral erector spinae plane block and pericapsular nerve group block—for pain relief after hip hemiarthroplasty. Eighty adults aged 50-90 with a hip fracture will receive one of the blocks before surgery. Researchers will measure pain…

This study compares two liquids used during gallbladder surgery to see which one reduces pain better afterward. Half the patients get bupivacaine, a numbing medicine, and the other half get plain saline. The goal is to find a safer, more effective way to manage pain after surgery…

This study compares three common IV painkillers—fentanyl, tramadol, and ibuprofen—given after keyhole lung surgery. The goal is to see which one controls pain best and helps patients breathe more easily in the first three days after surgery. The trial will enroll 135 adults aged …

This study tests whether giving oxytocin (the 'love hormone') through an IV during surgery can reduce pain and the need for opioid painkillers after a minimally invasive hysterectomy. Researchers will compare oxytocin to a placebo in 152 adults aged 18-65. The goal is to find a s…

This study tests whether giving the anti-inflammatory drug dexketoprofen through a vein can prevent or lessen the severe 'rebound pain' that often happens when a shoulder nerve block wears off. About 66 adults having arthroscopic shoulder surgery will receive either standard pain…

This study tests whether a specific nerve block, called the serratus posterior superior intercostal plane block, can reduce pain and opioid use after minimally invasive heart bypass surgery. Sixty adults undergoing this surgery will be randomly assigned to receive either the nerv…

This study compares two types of nerve blocks given before lung surgery to see which one better controls pain and reduces the need for strong painkillers. Sixty adults having planned lung surgery will receive either a paravertebral block or an erector spinae plane block, both usi…

This study compares two methods for controlling pain after hip surgery: a nerve block (fascia iliaca compartment block) and a spinal injection of nalbuphine. 120 adults having hip surgery under spinal anesthesia will be randomly assigned to one of the two methods. The main goal i…

This study tests a single injection of tegileridine fumarate, a new painkiller, for adults recovering from orthopedic surgeries like spinal fusion or knee replacement. Researchers aim to find the dose that works for 90% of patients without causing too many side effects. 180 parti…

This study tests a new ultrasound-guided nerve block called Quadro-Iliac Plane Block to manage pain after lower back surgery. Researchers want to see if it reduces the need for strong painkillers (opioids) and improves recovery. The trial will involve 80 adults scheduled for elec…

This study tests whether using virtual reality (VR) can help people recover better and leave the hospital sooner after major abdominal surgery. Sixty adults will either use VR for guided relaxation and mindfulness before and after surgery, or receive standard care. The goal is to…

This study looks at whether a special nerve block (paravertebral block) can better control pain after a mastectomy with immediate breast reconstruction compared to usual pain medicines. About 60 women aged 18-70 will take part. The goal is to see if the nerve block reduces pain a…

This study looks at whether a special ultrasound-guided nerve block (Quadro-Iliac Plane Block) can help control pain after lumbar spinal surgery. Researchers will follow 60 adults who are having elective back surgery and compare those who get the block plus standard pain medicine…

This study looks at whether getting women up and moving early after a C-section, plus drinking coffee, can help their bowels work better, reduce pain, and improve mood. About 60 women who had a planned C-section will take part. Researchers will check pain, bowel function, and psy…

This study compares two types of nerve blocks to control pain after total knee replacement. 78 adults will receive one of two combinations of ultrasound-guided injections near the knee. The goal is to see which approach reduces pain and the need for opioid painkillers in the firs…

This study tests whether giving a combination of two drugs (lidocaine and dexmedetomidine) during weight-loss surgery can reduce pain, inflammation, and cell stress afterward. About 104 adults having laparoscopic bariatric surgery will receive either the combo, one drug alone, or…

This study compares two methods of giving anesthesia during brain surgery: a computer-controlled system versus manual dosing by the anesthesiologist. The goal is to see which approach reduces confusion, pain, and nausea after surgery. About 70 adults having planned brain surgery …

This study tests whether using a mindfulness app for 4 weeks can lower anxiety in adults waiting for elective surgery. Forty participants will either use the app plus standard care or standard care alone. Researchers will measure anxiety on the day of surgery and also track pain …

This study is testing whether adding a small amount of morphine to the standard spinal anesthesia can improve pain control after a planned C-section, without causing serious side effects for mothers or babies. About 1,300 women will be randomly assigned to receive either morphine…

This study tests three different nerve blocks to control pain after shoulder surgery. The goal is to find a block that works as well as the standard one but doesn't cause breathing side effects. 120 adults scheduled for shoulder arthroscopy will be randomly assigned to one of the…

This study tests whether combining virtual reality with pleasant smells can lower pain and anxiety in people recovering from heart or lung surgery. About 80 adults scheduled for cardiothoracic surgery will either receive the VR-and-scent therapy or standard care. The goal is to s…

This study tests whether a long-acting painkiller (liposomal bupivacaine) works better than a standard one (ropivacaine) for pain after gallbladder removal. About 86 adults having laparoscopic cholecystectomy will receive one of the two drugs via a nerve block during surgery. Res…

This study tests a newer nerve block technique (external oblique intercostal block) against a standard one (erector spinae plane block) for pain after laparoscopic stomach removal. About 184 adults having this surgery will be randomly assigned to one of the two blocks. The main g…

This study tests whether spraying lidocaine inside the belly plus giving it through an IV can reduce pain after laparoscopic fibroid removal. One hundred adults having this surgery will be randomly assigned to get lidocaine or a placebo. The main goal is to see if fewer people ha…

This study compares two types of nerve blocks—Deep Iliacus Plane Block and Suprainguinal Fascia Iliaca Block—for pain relief after hip replacement surgery. Seventy adults having hip surgery will receive one of the two blocks at the end of their operation. Researchers will measure…

This study tests whether a specific nerve block, called an external oblique intercostal block, can reduce pain and the need for opioid painkillers after laparoscopic gallbladder removal. Researchers will compare patients who receive the block to those who get standard care. The t…

This study tests a new type of nerve block called a deep rectus sheath block to see if it reduces pain and the need for morphine after laparoscopic gallbladder removal. Sixty adults scheduled for this surgery will receive the block or standard care. Researchers will measure how m…

This study tests whether a newer root canal medication called Bio-C Temp causes less pain between dental visits than the standard calcium hydroxide. Sixty adults needing root canal retreatment will receive one of the two medications. Their pain levels and painkiller use will be t…

This study tests whether tea tree oil mouthwash can reduce pain, swelling, and jaw stiffness after wisdom tooth removal as well as the standard chlorhexidine mouthwash. Fifty-four adults getting their lower wisdom teeth out will use one of the two mouthwashes three times daily fo…

This study compares a new gel wound dressing called Ora-Aid to a standard plastic stent for reducing pain after gum graft surgery. Twenty adults having the procedure will be randomly assigned to one of the two treatments. Researchers will measure pain levels, painkiller use, woun…

This study tests whether a specific nerve block, called the serratus posterior superior intercostal plane block, can reduce pain and the need for opioid painkillers after minimally invasive heart valve surgery. 90 adults will be randomly assigned to receive either the nerve block…

This study compares an herbal extract called Aescin (Reparil®) to the common painkiller ibuprofen for managing pain, swelling, and jaw stiffness after wisdom tooth removal. About 100 adults aged 18-40 will take either Aescin or ibuprofen for five days after surgery. Researchers w…

This study tests if a safe, non-invasive nerve stimulation on the ear can lower pain and the need for strong painkillers after abdominal or urologic surgery. 174 adults will receive either real stimulation at different frequencies or a sham (fake) treatment before and after surge…

This study tests three different agents (sodium hypochlorite, chlorhexidine, and cold saline) to stop bleeding during a partial pulpotomy, a dental procedure that removes part of the tooth's pulp. Researchers will track pain levels and pulp survival in 75 adults with cavities tha…

This study tests if giving ketamine before laparoscopic sleeve gastrectomy (a type of weight-loss surgery) can reduce pain after the operation. Researchers will compare how long it takes for patients to need extra pain medicine. The study includes 90 adults with a BMI between 35 …

This study tests if a numbing injection near the breastbone, given before heart surgery, can lower the amount of strong painkillers (opioids) needed during the operation. The goal is to reduce side effects like nausea and slow breathing. The study will include 80 adults having pl…

This study tests two different ointments—lignocaine and GTN—to see which one works better for pain after hemorrhoid surgery. About 64 adults with severe hemorrhoids will take part. The goal is to find which ointment reduces pain, helps wounds heal faster, and makes patients more …

This study compares two ways to manage pain after minimally invasive pectus excavatum repair: freezing the intercostal nerves (cryoanalgesia) versus an epidural block. About 40 participants aged 13 and older will be randomly assigned to one method. The goal is to see which approa…

This study tests a special gel called RADA-16 (PuraStat) to see if it helps stop bleeding and reduce pain after tonsil removal. About 134 adults having tonsillectomy will either get the gel or standard care. Participants will track their symptoms through online surveys every two …

This study tests if simple breathing exercises (pranayama) can reduce pain and improve comfort for women after a cesarean section. About 100 women who had a planned C-section and feel at least moderate pain will be asked to do these exercises. The goal is to see if this drug-free…

This study looks at whether a special nerve block called the Quadro-Iliac plane block can help people recover better after laparoscopic inguinal hernia surgery. About 70 adults having this surgery will either get the nerve block or a placebo, and their recovery quality will be me…

This study tests whether having patients keep a pain diary after gallbladder surgery helps them report their pain more accurately than standard methods. About 142 adults having laparoscopic gallbladder removal will either use a diary or receive usual care. The goal is to improve …

This study tests whether injecting a local anesthetic (bupivacaine) at the incision sites and vaginal cuff can reduce pain after laparoscopic hysterectomy. About 120 women having the surgery for non-cancer reasons will be randomly assigned to receive the injection or standard car…

This study tests whether a local anesthetic injection (paracervical block) given during vNOTES surgery can lower pain right after the procedure. About 58 women having surgery for pelvic organ prolapse will be randomly assigned to receive either the numbing medicine or a placebo. …

This study tests whether a numbing medicine injected around the cervix during vaginal hysterectomy for prolapse can lower pain and reduce the need for strong opioid painkillers afterward. About 56 participants will receive either the numbing medicine or a placebo (saltwater) inje…

This study looks at 60 adults having lumbar disc surgery to see if giving a nerve block (ESPB) before or during surgery better reduces pain and the need for strong painkillers (opioids). The goal is to improve recovery, reduce side effects like nausea, and keep blood pressure sta…

This study compares opioid-free anesthesia to standard opioid-based anesthesia in 40 adults undergoing open abdominal aortic aneurysm repair. The goal is to see if avoiding opioids reduces the body's stress response and inflammation during and after surgery. Researchers will meas…

This study tests whether using a special brain-wave monitor (Conox) during children's tonsil and adenoid surgery can lower the amount of strong painkillers needed and improve recovery. About 128 children aged 3 to 12 will be randomly assigned to either standard monitoring or Cono…

This study tests whether a special nerve block, called an erector spinae plane block, can reduce pain and the need for strong painkillers after kidney removal surgery. About 66 adults having open nephrectomy will be randomly assigned to get either standard pain relief or the nerv…

This study tests whether a higher dose (8 mg) of the steroid dexamethasone works better than a lower dose (4 mg) or a placebo for pain after dental implant surgery. About 138 adults getting a single tooth implant will be randomly assigned to one of three groups. Pain will be meas…

This study tests a new medicine called TLC590 for pain after bunionectomy (foot bone surgery). About 300 adults will receive either TLC590, a standard painkiller, or a placebo. The goal is to see if TLC590 reduces pain and the need for opioid painkillers in the first 72 hours aft…

This study compares two techniques used during lumbar fusion surgery to see which one better reduces bleeding and pain after the operation. About 62 adults having back fusion surgery will be randomly assigned to receive either a large-volume injection of numbing medicine with a v…

This study tests whether a compressive cryotherapy device (Game Ready®) can reduce the need for opioid painkillers after total knee replacement surgery. About 74 adults aged 60-80 will be randomly assigned to use either the device or traditional ice packs four times daily for a w…

This study compares two types of nerve blocks to see which one works better for pain after mastectomy surgery. About 66 women having a mastectomy will receive one of the two blocks before surgery. The goal is to find a method that reduces pain, lowers the need for painkillers, an…

This study tests two types of nerve blocks to see which one works better for pain after breast cancer surgery. 50 women having a mastectomy will get either a newer or a standard block. The goal is to find a way to reduce the need for strong painkillers like morphine and help pati…

This study tests whether a combination of two medicines given as a nose spray can reduce pain in children after tonsil and adenoid surgery. About 160 children aged 3 to 7 will take part. The goal is to find a safe and effective way to manage pain without strong side effects.

This study tests a new pain-blocking injection called the External Oblique Intercostal Plane Block for people having major upper abdominal surgery (like stomach, liver, or pancreas surgery). The goal is to see if it reduces the need for strong painkillers (opioids) and improves r…

This study tests if a nerve block done during laparoscopic hernia repair can lower pain and help people recover faster. One hundred adults having elective hernia surgery will be randomly assigned to get the block or not. The block uses a numbing medicine injected under direct vis…

This study compares two common pain medicines, fentanyl and remifentanil, given during gallbladder surgery to see which one helps the bowel start working again sooner and controls pain better. About 106 adults having planned laparoscopic gallbladder removal will take part. The go…

This study tests whether a nerve block called the external oblique intercostal plane block can reduce pain after liver transplant surgery. Sixty adults receiving a liver transplant will be split into two groups: one gets the nerve block plus standard care, the other gets standard…

This study tests whether giving ketamine during surgery can reduce pain, lower the need for opioids, and improve depression and PTSD symptoms in adults with serious orthopedic injuries. About 90 participants will be randomly assigned to receive either ketamine or standard anesthe…

This study looks at two different ways to numb the belly area in children aged 1 to 7 who are having surgery for an undescended testicle. The goal is to see which method reduces pain and the need for extra pain medicine after the operation. About 70 children will take part, and n…

This study compares two types of nerve blocks (meta-PENG and fascia iliaca) to see which one better reduces pain during hip fracture surgery. About 80 adults having hip fracture surgery will receive one of the blocks as part of their routine care. The goal is to find which block …

This study looks at two different methods to control pain after elective lower back surgery. One method uses an ultrasound-guided nerve block, while the other uses standard pain medications given through a vein. Researchers will use a special monitor that tracks heart rate to see…

This study looks at whether giving morphine during coronary artery bypass surgery can lower pain after the operation. About 60 adults having elective bypass surgery will be randomly assigned to receive either morphine or standard care. Researchers will measure pain levels and sid…

This study compares two types of pain blocks—sacral erector spinae plane block and dorsal penile nerve block—in 70 boys aged 1-7 years having hypospadias surgery. The goal is to see which block provides better pain control after the operation. Researchers will measure pain scores…

This study looks at whether a special nerve block called FRONT can help people recover better after hip replacement surgery. About 80 adults having hip replacement will either get this nerve block or standard care. The main goal is to see if it improves their overall recovery and…

This study compares two types of ultrasound-guided nerve blocks to control pain after laparoscopic gallbladder removal. 70 adults having elective surgery will receive one of the two blocks, and researchers will measure how much pain medication they need in the first 24 hours. The…

This study tests two types of ultrasound-guided nerve blocks to see which better controls pain after open kidney cancer surgery. 56 adults scheduled for nephrectomy will receive either an external oblique intercostal plane block or a posterior transversus abdominis plane block. T…

This study compares two types of nerve blocks to control pain after open-heart surgery through the breastbone. Fifty adults having planned heart surgery will receive either a combination of two blocks or a single block, along with standard pain medicines. The goal is to see which…

This study tests whether a 15-20 minute hypnosis session before abdominal surgery can lower anxiety and pain. About 48 adults will be randomly assigned to receive either hypnosis or standard psychological preparation. The goal is to see if hypnosis leads to less worry before surg…

This study looks at two ways to control pain after laparoscopic kidney donation surgery: a nerve block injected into the belly muscles before surgery, or numbing medicine injected into the surgical cuts at the end. Pain can make people take shallow breaths, which may harm lung fu…

This study looks at whether a non-invasive device called TENS, which sends mild electrical pulses through the skin, can help people who are having their gallbladder removed. The goal is to see if it lowers anxiety before surgery, reduces pain afterward, and makes patients more sa…

This study compares two types of pain blocks—sacral erector spinae plane block and caudal epidural block—in 60 children aged 6 months to 7 years undergoing hypospadias repair. The goal is to see which method provides better pain relief in the first 24 hours after surgery. Researc…

This study tests whether a special nerve block (quadro-iliac plane block) can reduce pain and the need for painkillers after kidney stone surgery. About 60 adults having this surgery will be randomly assigned to get the block or not. The main goal is to see if the block lowers pa…

This study compares two pain relief methods for adults having video-assisted chest surgery. One method is a nerve block injection near the ribs, and the other is a spinal injection of morphine. The goal is to see which approach reduces pain and the need for opioid painkillers aft…

This study compares two types of nerve blocks (paravertebral block and external oblique intercostal block) to standard pain medicine for people having gallbladder removal surgery. The goal is to see which method reduces pain and the need for opioids like tramadol. About 147 adult…

This study aims to find the most effective dose of morphine given into the spinal fluid to control pain after a C-section. Researchers will test different doses in 100 healthy women having planned C-sections, adjusting the dose based on how well the previous participant's pain wa…

This study compares a new nerve block technique (EOIB) to a standard combination of blocks for pain after laparoscopic stomach removal. The goal is to see if the new method works just as well or better, reducing the need for strong painkillers. One hundred adults scheduled for th…

This study looks at whether adding a TAP block (a numbing injection in the belly wall) to standard pain care helps women feel less pain after a C-section. About 70 women having a planned C-section under spinal anesthesia will be randomly assigned to get either the TAP block or us…

This study tests whether a nerve block called a rectus sheath block can reduce pain and the need for strong painkillers after heart surgery. About 75 adults having heart surgery with chest tubes will be randomly assigned to receive the block or not. Researchers will measure pain …

This study tests whether a special nerve block (rhomboid intercostal block) can reduce pain and the need for opioid painkillers after breast implant surgery. About 40 women will be randomly assigned to receive either the nerve block plus standard anesthesia or standard anesthesia…

This study tests two types of nerve blocks (EXORA and ESP) to see which one works better for pain after gallbladder removal. About 114 adults having laparoscopic gallbladder surgery will receive one of the blocks before surgery. The goal is to find which block reduces the need fo…

This study is for children under 6 years old who need heart surgery. It tests a pain medicine called EXPAREL to see if it works well and is safe compared to a standard painkiller. The medicine is given near the surgery area to help with pain after the operation. About 48 children…

This study looks at whether giving a numbing injection to the belly muscles before or after gallbladder surgery helps reduce pain and the need for strong painkillers. About 96 adults having their gallbladder removed will be randomly assigned to get the injection either before the…

This study tests whether melatonin (a natural sleep hormone) works as well as pregabalin (a nerve pain drug) for managing pain and anxiety after spine surgery. About 105 adults aged 21-60 having elective spine surgery will receive one of the two medicines right after surgery. Res…

This study tests whether injecting botulinum toxin (Botox) into the anal muscle one week before hemorrhoid removal surgery can lower pain after the operation. About 292 adults with severe hemorrhoids will get either Botox or a placebo injection before surgery. Researchers will tr…

This study tests whether giving a combination of nerve blocks right after heart bypass surgery can reduce pain and the need for strong painkillers like opioids. About 56 adults having planned bypass surgery will be randomly assigned to get either the nerve blocks plus standard pa…

This study is testing whether a low dose of ketamine can reduce the amount of strong painkillers (opioids) needed and improve pain control in people recovering from thoracic endovascular aortic repair (TEVAR). About 30 adults scheduled for this surgery will receive either ketamin…

This study tests whether rinsing the belly with saltwater during a scarless hysterectomy (vNOTES) can lower pain and the need for painkillers after surgery. About 94 women having the procedure will be randomly assigned to get the rinse or not. The goal is to see if this simple st…

This study tests whether combining two ultrasound-guided pain blocks (M-TAPA and EXOP) works better than M-TAPA alone for controlling pain after laparoscopic gynecologic surgery. About 86 women will have their pain scores, need for extra pain medicine, and recovery quality measur…

This study tests whether a gel called RADA16 can reduce pain and bleeding after children have their tonsils removed. About 134 children aged 3 to 17 will either get the gel or standard care. Families will track symptoms through online surveys for 30 days after surgery.

This study looks at how a person's genes and other factors influence pain after surgery. Researchers will follow 5,000 adults having planned operations to see which genetic variations are linked to pain levels and painkiller use. The goal is to better understand and personalize p…

This study is looking at 150 women having breast cancer surgery to see if their sleep quality in the month before surgery can predict how much pain and inflammation they have afterward. Participants fill out a sleep questionnaire before surgery, and their pain and painkiller use …

This study watches 254 adults after elective surgery to see what factors—like age, type of surgery, or anesthesia—affect how much pain medicine they need in the recovery room. No new treatments are given; researchers just collect data from normal care. The goal is to help doctors…

This study looks at whether a person's genetic makeup influences how well the painkiller nalbuphine works after abdominal or pelvic surgery. Researchers will collect blood samples from 263 adults before and after surgery to analyze genes linked to pain relief. The goal is to impr…

This study tests a new device that measures pain by looking at changes in pupil size after a gentle electrical stimulation. Researchers will enroll 100 children and teens ages 6 to 21 who are having surgery or bone marrow transplant. The device is non-invasive and does not change…

This study looks at whether the intense pain people feel right before emergency surgery can turn into chronic pain that lasts for months. Researchers will follow 693 adults having emergency orthopedic or abdominal surgery. They want to see if the level of pain before surgery pred…

This study looks at why some people have more pain than others after gum graft surgery. About 93 adults will answer surveys and track their pain for two weeks. The goal is to find out which factors—like anxiety or gum thickness—affect recovery, so doctors can better manage pain i…