C-Section pain breakthrough: scientists pinpoint ideal morphine dose
NCT ID NCT07023497
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study aims to find the most effective dose of morphine given into the spinal fluid to control pain after a C-section. Researchers will test different doses in 100 healthy women having planned C-sections, adjusting the dose based on how well the previous participant's pain was controlled. The goal is to achieve at least 12 hours of pain relief with a low pain score (3 or less out of 10) while minimizing side effects.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 100 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jul 2023
- Expected to finish
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Sep 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 50 years
- Sex
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Female participants only
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * term parturient * single pregnancy * elective cesarean delivery * adult parturient * ASA II Exclusion Criteria: * participants under the age of 18 * extreme somatometric characteristics * lack of patient consent * absolute contraindications for spinal anesthesia * urgent cesarean section * presence of known fetal anomalies * onset of labor prior to administration of the block * history of chronic pain * use of opioids (systemic or otherwise) for any reason (e.g., chronic malignant pain) * communication difficulties (e.g., language barriers, cognitive impairments) * allergy or hypersensitivity to morphine * severe arrhythmia or other serious cardiovascular conditions * severe hepatic or renal insufficiency
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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University Hospital of Ioannina
RECRUITINGIoannina, Epirus, 455 00, Greece
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