POSTOPERATIVE PAIN

This study compares two types of nerve blocks (paravertebral block and erector spinae plane block) in 60 adults undergoing lung surgery. The goal is to see which block better reduces the need for strong pain medicines during and after surgery, using a special monitor to guide dos…

This study tests whether a special nerve block (RIFP block) can reduce pain and the need for morphine in people who donate part of their liver. 64 donors will either get the block plus standard pain relief, or standard pain relief alone. The goal is to see if the block helps them…

This study compares two ways to manage pain after minimally invasive surgery for pectus excavatum (a sunken chest). One method freezes the nerves between the ribs (cryoanalgesia), and the other uses an epidural block. The goal is to see which approach leads to a shorter hospital …

This study looks at whether adding a low dose of morphine to the usual spinal anesthesia can better manage pain after a planned cesarean section, without causing serious side effects for mothers or newborns. About 1,300 women having planned C-sections will receive either morphine…

This study tests whether adding a second nerve block (EXOP) to the standard M-TAPA block provides better pain relief after laparoscopic gynecologic surgery. About 86 adults will be enrolled, and their pain levels, need for extra pain medication, and recovery quality will be track…

This study compares two types of pain blocks (QLB and QIPB) in 70 children aged 1-7 years having surgery for an undescended testicle. The goal is to see which block reduces pain and the need for extra pain medicine after surgery. Both blocks are given with ultrasound guidance bef…

This study compares two pain-blocking techniques for people having total knee replacement. Both methods target the back of the knee to reduce pain without affecting leg strength. The goal is to see which approach provides better pain relief, lowers the need for opioids, and helps…

This study tests if a special nerve block (SPSIP block) works better than standard local numbing medicine for reducing pain during port catheter implantation. About 70 adults having this procedure will be randomly assigned to one of the two pain relief methods. The goal is to see…

This study tests whether a special nerve block (called FRONT) can help people recover better after hip replacement surgery. About 80 adults having hip replacement will either get the nerve block or standard care. The goal is to see if the block reduces pain and improves overall r…

This study tests whether asking patients to keep a pain diary after gallbladder surgery helps them report pain more accurately than standard methods. About 142 adults having their first laparoscopic gallbladder removal will either use a diary or receive usual care. The goal is to…

This study tests three different nerve block methods to manage pain after shoulder arthroscopy. The goal is to find a technique that works well but avoids the common side effect of breathing problems. About 120 adults having shoulder surgery will be randomly assigned to one of th…

This study looks at two common pain medicines, fentanyl and remifentanil, used during gallbladder removal surgery. The goal is to see which one helps the bowel start working again sooner and controls pain better after the operation. About 106 adults having planned laparoscopic ga…

This study compares a nerve block (paravertebral block) to standard pain medication in 60 women having a mastectomy with immediate breast reconstruction. The goal is to see if the nerve block reduces pain right after surgery and may help prevent long-term chronic pain. Participan…

This study looks at whether giving numbing injections before or after gallbladder surgery helps reduce pain and the need for strong painkillers. About 96 adults having planned gallbladder removal will be randomly assigned to receive the injections either before the surgeon starts…

This study tests whether a special nerve block, called a transversalis fascia plane block, can help control pain after kidney donation surgery. Half of the 50 participants will receive the nerve block plus standard anesthesia, while the other half will receive only standard anest…

This study looks at two different methods to control pain after lower back surgery: a nerve block injection or pain medicine through an IV. About 100 adults having elective lumbar spine surgery will be randomly assigned to one of these groups. Researchers will use a special monit…

This study compares two types of ultrasound-guided nerve blocks to control pain after laparoscopic gallbladder removal. 70 adults will receive one of the two blocks, and researchers will measure how much pain medication they need in the first 24 hours. The goal is to find a safer…

This study tests whether a nasal spray containing two medicines (dexmedetomidine and esketamine) can reduce pain in children after tonsil and adenoid surgery. About 160 children aged 3 to 7 will take part. The goal is to find a safe and effective way to manage pain without strong…

This study tests whether tea tree oil mouthwash works as well as chlorhexidine mouthwash for reducing pain, swelling, and jaw stiffness after having a wisdom tooth removed. About 54 adults will use one of the two mouthwashes three times a day for a week. Researchers will measure …

This study tests whether a numbing injection (paracervical block) given during vNOTES surgery can lower pain after pelvic organ prolapse repair. About 58 women will be randomly assigned to receive either the numbing medicine or a placebo. The main goal is to measure pain levels 6…

This study compares two types of nerve blocks (EXORA and ESP) for pain relief in 114 adults having gallbladder removal surgery. The goal is to see which block better reduces the need for strong painkillers (opioids) and helps patients recover faster. Both blocks are given before …

This study tests if a numbing injection near the breastbone, given before heart surgery, can lower the amount of strong painkillers (opioids) needed during the operation. The goal is to reduce side effects like nausea and slow breathing. The study will include 80 adults having pl…

This study tests whether giving a combination of two drugs (lidocaine and dexmedetomidine) during laparoscopic weight-loss surgery can reduce pain, inflammation, and oxidative stress afterward. About 104 adults having bariatric surgery will be randomly assigned to receive the com…

This study tests whether using a mindfulness app for 4 weeks before surgery can lower anxiety on the day of the operation. 40 adults scheduled for elective surgery will either use the app plus standard care or receive standard care alone. Researchers will measure anxiety levels, …

This study looks at whether a newer dental material (Bio-C Temp) can reduce pain after root canal retreatment better than the standard calcium hydroxide. About 60 adults needing retreatment on a single-root tooth will be randomly assigned to one of the two medicaments. They will …

This study looks at whether a simple, non-invasive device called TENS can help people recover more comfortably after laparoscopic gallbladder removal. TENS uses mild electrical pulses through the skin to calm nerves. Researchers will compare patients who get TENS plus standard ca…

This study looks at whether getting women up and moving early after a C-section, plus drinking coffee, can help their bowels work better, reduce pain, and improve mood. About 60 women who had a planned C-section will take part. The goal is to find simple ways to make recovery smo…

This study compares 4mg and 8mg of dexamethasone (a steroid) to a placebo for controlling pain after dental implant surgery. About 138 adults will be randomly assigned to one of three groups. Pain levels and the number of pain pills needed will be tracked for 6 days after surgery…

This study is for children under 6 years old who need heart surgery. It compares a long-lasting pain medicine called EXPAREL with a standard painkiller to see which works better and is safer. The goal is to improve pain control after surgery in young children.

This study tests whether combining virtual reality (VR) with pleasant scents can help reduce pain and anxiety in people recovering from major heart or lung surgery. About 80 adults scheduled for cardiothoracic surgery will either receive the VR and scent therapy or standard care.…

This study looks at 60 adults having lumbar disc surgery to see if giving a nerve block (ESPB) before surgery works better than giving it during surgery. The goal is to reduce pain, the need for strong painkillers (opioids), and side effects like nausea. Researchers will also che…

This study compares two types of nerve blocks (DIPB and SIFIB) to see which provides better pain relief after hip replacement surgery. Seventy adults having hip surgery will be randomly assigned to receive one of the blocks. Researchers will measure pain levels, opioid use, and l…

This study looks at whether a special nerve block called the Quadro-Iliac plane block can help people recover better after laparoscopic inguinal hernia surgery. About 70 adults having this surgery will either get the nerve block or a placebo, and their recovery quality will be me…

This study tests whether a rectus sheath block, a type of nerve block, can reduce pain and the need for opioid painkillers after cardiac surgery. About 75 adults having heart surgery with chest tubes will be randomly assigned to get the block or not. Researchers will measure pain…

This study tests whether giving a single dose of ketamine during surgery can reduce pain, lower the need for opioids, and improve depression and PTSD symptoms in adults with serious orthopedic injuries. About 90 participants will be randomly assigned to receive either ketamine or…

This study aims to find the ideal dose of spinal morphine to control pain after a C-section. Researchers will test different doses in 100 healthy women having planned C-sections, adjusting the dose based on each woman's pain relief. The goal is to keep pain scores low for at leas…

This study tests whether a numbing injection around the cervix during vaginal hysterectomy for pelvic organ prolapse can lower pain and reduce the need for opioid painkillers after surgery. About 56 adults having this surgery will be randomly assigned to receive either the numbin…

This study tests whether giving a set of nerve blocks during heart bypass surgery can reduce pain and the need for strong painkillers (opioids) afterward. About 56 adults having planned bypass surgery will be randomly assigned to receive either the nerve blocks plus standard pain…

This study looks at whether using lidocaine as a spray inside the belly plus an IV injection can lower pain after laparoscopic fibroid removal. About 100 adults having this surgery will be randomly assigned to get the lidocaine combo or a placebo. The main goal is to see if fewer…

This study looks at whether a low dose of ketamine can lower the amount of strong painkillers (opioids) needed and improve pain control in people recovering from a type of aortic repair surgery called TEVAR. About 30 adults scheduled for this surgery will receive either ketamine …

This study tests whether a special nerve block (called a rhomboid intercostal block) can reduce pain and the need for opioid painkillers after breast implant surgery. About 40 women will be randomly assigned to receive either the nerve block plus standard anesthesia or standard a…

This study tests whether giving oxytocin (a natural hormone) through an IV during surgery can reduce pain and the need for opioid painkillers after a minimally invasive hysterectomy. About 152 adults having this surgery will be randomly assigned to receive either oxytocin or a pl…

This study compares two types of nerve blocks (paravertebral and external oblique intercostal) to standard pain medication for people having gallbladder removal surgery. The goal is to see which approach reduces pain and the need for opioids like tramadol. About 147 adults will t…

This study tests whether a gel called RADA16 can improve recovery for children aged 3 to 17 after tonsil removal. About 134 children will either get the gel or standard care. Researchers will track pain and bleeding for 30 days after surgery.

This study tests whether using a special brain monitor (Conox) during anesthesia helps children aged 3 to 12 need less opioid pain medicine during tonsil and adenoid surgery. Half the children will get standard anesthesia care, and the other half will have anesthesia guided by th…

This study tests whether melatonin (a natural sleep hormone) works as well as pregabalin (a nerve pain drug) for reducing pain and anxiety after spine surgery. About 105 adults aged 21-60 having elective spine surgery will be randomly assigned to receive one of the two medicines.…

This study tests a special gel (RADA-16) applied during tonsil removal to see if it reduces bleeding and pain after surgery. About 134 adults having their tonsils out will either get the gel or standard care. Participants will track their symptoms through online surveys every oth…

This study tests if a nerve block done during laparoscopic hernia repair can lower pain and help patients recover faster. One hundred adults having elective hernia surgery will be randomly assigned to receive the block or standard care. Pain levels will be measured at several tim…

This study compares two types of nerve blocks to manage pain after heart surgery through the breastbone. Fifty adults having planned heart surgery will receive either a combination of two blocks or a single block, along with standard pain medicines. The goal is to see which metho…

This study compares two ways to manage pain after a common gum graft procedure. Twenty adults will receive either a new oral wound dressing called Ora-Aid or a standard plastic palatal stent. The main goal is to see which method reduces pain and the need for painkillers during th…

This study compares two ways to control pain after laparoscopic kidney donation surgery: a nerve block injected into the abdominal wall before surgery versus numbing medicine injected into the incision sites at the end of surgery. The goal is to see which method better preserves …

This study compares two pain-relief medicines given during gallbladder surgery to see which one works better and helps patients recover faster. About 86 adults having laparoscopic gallbladder removal will receive either liposomal bupivacaine or ropivacaine as a nerve block. Resea…

This study tests a program for adults who take opioids for chronic pain before surgery. The program includes pain education, therapy, and a mobile app to help patients reduce opioid use and manage pain better after surgery. Researchers will compare how many patients successfully …

This study compares two pain relief methods for people having hip surgery: a fascia iliaca block (injection near the hip nerve) and intrathecal nalbuphine (injection into spinal fluid). The goal is to see which provides longer-lasting pain control. 120 adults will take part, and …

This study compares two techniques used during lower back fusion surgery to reduce bleeding and pain after the operation. One method injects a numbing and blood-vessel-constricting medicine around the surgery area, while the other uses a targeted nerve block. About 62 adults havi…

This study tests whether an ultrasound-guided nerve block (erector spinae plane block) can better manage pain after kidney removal surgery compared to standard opioid-based methods. About 66 adults having open nephrectomy will be randomly assigned to receive either the nerve bloc…

This study compares an herbal extract called Aescin (Reparil®) to ibuprofen for managing pain, swelling, and jaw stiffness after wisdom tooth removal. About 100 adults aged 18-40 will take either Aescin or ibuprofen for five days after surgery. Researchers will measure pain, faci…

This study tests a newer nerve block (EOIB) against a standard one (ESPB) for pain after laparoscopic stomach cancer surgery. About 184 adults will receive one of the two blocks, and researchers will measure how much pain medication they need in the first 24 hours. The goal is to…

This study tests whether pranayama (controlled breathing) exercises can reduce pain and improve comfort for women after a cesarean section. About 100 women who had a planned C-section under spinal anesthesia and report moderate to severe pain will be enrolled. Participants will p…

This study tests whether adding an ultrasound-guided nerve block to standard pain medicine can reduce the need for strong painkillers after lower back surgery. Fifty adults having elective lumbar spine surgery will be randomly assigned to receive either the nerve block plus stand…

This study compares two types of nerve blocks to manage pain after heart surgery through the breastbone. About 50 adults will receive either one block or a combination of two blocks. The goal is to find which method provides better pain relief and reduces the need for strong pain…

This study compares two types of nerve blocks for pain after hip surgery. 80 adults aged 50-90 with a broken hip will receive either a sacral erector spinae plane block or a pericapsular nerve group block. The goal is to see which provides better pain relief while preserving leg …

This study looks at whether a special ultrasound-guided nerve block (Quadro-Iliac Plane Block) can help control pain after lumbar spine surgery. About 60 adults having elective back surgery will be observed. The goal is to see if the block lowers pain scores and reduces the need …

This study tests whether giving ketamine before laparoscopic sleeve gastrectomy (a weight-loss surgery) can reduce pain after the operation. Researchers will compare how long it takes for patients to need extra pain medicine. The study involves 90 adults with a BMI between 35 and…

This study tests whether using virtual reality (VR) can help people recover better and leave the hospital sooner after major abdominal surgery. Sixty adults will either use VR for guided relaxation and mindfulness before and after surgery, or receive standard care. The goal is to…

This study tests two different nerve-blocking techniques to see which one works better for pain after mastectomy (breast removal surgery). About 66 women having this surgery will receive one of the two blocks before the operation. Researchers will measure pain levels, how soon pa…

This study tests two types of ultrasound-guided nerve blocks to manage pain after breast cancer surgery. Fifty women having a mastectomy will receive either a newer SPSIP block or a standard ESPB block. The goal is to see which one reduces the need for morphine and improves recov…

This study tests a new pain-relief technique called the Quadro-Iliac Plane Block for people having lower back surgery. The block uses ultrasound to guide numbing medicine into the muscles around the hip bone. Researchers want to see if it reduces the need for strong painkillers a…

This study is testing whether a 15-20 minute hypnosis session, given just before abdominal surgery, can lower patients' anxiety and pain. About 48 adults having abdominal surgery will be split into two groups: one gets hypnosis, the other gets standard preparation. Researchers wi…

This study tests whether injecting botulinum toxin (Botox) into the anal muscle one week before hemorrhoid surgery can lower pain after the operation. About 292 adults with severe hemorrhoids will receive either Botox or a placebo injection. Researchers will track pain levels, pa…

This study tests whether a specific nerve block, given before surgery, can reduce pain and the need for strong painkillers after minimally invasive heart bypass surgery. Sixty adults will be randomly assigned to receive either the nerve block plus standard care or standard care a…

This study tests a new type of nerve block, called a deep rectus sheath block, to see if it reduces pain after laparoscopic gallbladder removal. Sixty adults having this surgery will receive the block, and researchers will measure how much morphine they need in the first 24 hours…

This study looks at whether a specific nerve block (external oblique intercostal plane block) can better control pain after liver transplant surgery. Sixty adults getting a liver transplant will be split into two groups: one gets the nerve block plus standard care, the other gets…

This study looks at whether giving morphine during coronary artery bypass surgery can lower pain levels after the operation. Sixty adults having elective bypass surgery will be randomly assigned to receive either morphine or standard care during the procedure. Researchers will me…

This study tests two different pain-relief methods for people having chest surgery with a camera. One method is a nerve block injection near the ribs, and the other is a spinal injection of morphine. The goal is to see which approach reduces the need for strong painkillers and im…

This study compares two types of pain blocks—sacral erector spinae plane block and dorsal penile nerve block—in 70 boys aged 1-7 years having hypospadias surgery. The goal is to see which block provides better pain relief after the operation. Pain scores and side effects will be …

This study tests two ways of giving anesthesia during brain surgery to see which one leads to less confusion, pain, and nausea after the operation. About 70 adults aged 18-60 having planned brain surgery will take part. One method uses a computer to control the drug dose, while t…

This study tests two different ointments—lignocaine and glyceryl trinitrate (GTN)—to see which one works better for pain relief after hemorrhoid surgery. About 64 adults with severe hemorrhoids will take part. The goal is to find which ointment reduces pain, helps wounds heal fas…

This study tests a newer nerve block method (EOIB) against a standard combination (TAP+RSB) for controlling pain after laparoscopic stomach cancer surgery. About 100 adults will be randomly assigned to receive one of the two blocks before surgery. The goal is to see if the newer …

This study tests whether injecting a numbing medicine (bupivacaine) into the small cuts and the top of the vagina after laparoscopic hysterectomy can lower pain. About 120 women having this surgery for non-cancer reasons will be randomly assigned to get the injection or not. Pain…

This study is testing a single dose of a new pain medicine called tegileridine fumarate to find the best amount for controlling pain after orthopedic surgeries like hip or knee replacement. About 180 adults will receive the drug right after surgery, and researchers will adjust th…

This study tests three different agents (sodium hypochlorite, chlorhexidine, and cold saline) to stop bleeding during a partial pulpotomy, a dental procedure that removes only the top part of the tooth's nerve. The goal is to see which agent leads to less pain and better nerve su…

This study tests an experimental pain-relief injection called TLC590 in 300 adults having bunionectomy (foot bone surgery). The goal is to see if it reduces pain for 3 days after surgery and helps people avoid stronger opioid painkillers. Participants are randomly assigned to get…

This study looks at why some people feel more pain than others after having gum tissue taken from the roof of the mouth for dental surgery. About 93 adults will answer questionnaires and track their pain for two weeks. The goal is to find out which personal and surgical factors a…

This study is testing a new, non-invasive device that measures pain in children and teens by tracking changes in pupil size. Researchers want to see if it can provide a more objective way to assess pain than current methods. The study will include 100 participants ages 6 to 21 wh…

This study looks at whether parents who feel confident helping their child be independent can lower their child's pain after minor surgery. About 150 children aged 3 to 18 and their parents will take part at one hospital in Turkey. Parents fill out questionnaires, and children ra…

This study is observing 150 women scheduled for breast cancer surgery to see if their sleep quality before the operation can predict how much pain and inflammation they will have afterward. Participants will fill out a sleep questionnaire, and researchers will track their pain le…

This study looks at whether the intense pain people feel right before emergency surgery can lead to pain that lasts for months afterward. Researchers will follow about 700 adults having emergency orthopedic or abdominal surgery. They want to see if the level of pain before surger…

This study watches 254 adults after elective surgery to see what factors affect how much pain medicine they need in the recovery room. Researchers will collect data from normal care—no extra treatments or changes. The goal is to find patterns that help doctors personalize pain ma…

This study is observing 5,000 adults having elective surgery to see if their genes influence how much pain they feel afterward. Researchers will also look at other factors like medication use and recovery after one year. The goal is to better understand why some people have more …

This study looks at whether a person's genes change how well the painkiller nalbuphine works after abdominal surgery. Researchers will take blood samples from 263 adults before and after surgery to find gene patterns linked to pain relief. The goal is to make pain treatment safer…

This study looks at how patients experience pain checks after planned surgery. Researchers want to know if these checks feel supportive or stressful, and how that affects trust in nurses and willingness to report pain. About 300 adults having elective general surgery will fill ou…