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Heart surgery patients may get better pain relief with morphine during operation

NCT ID NCT07472959

Symptom relief Sponsor: Istanbul University - Cerrahpasa Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether giving morphine during coronary artery bypass surgery can improve pain control and reduce side effects like nausea after the operation. Sixty adults scheduled for elective heart surgery will be randomly assigned to receive either morphine or no additional morphine during the procedure. Researchers will measure pain levels and side effects in the first 24 hours after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
morphine
What this could lead to
If it works, this could show that giving morphine during heart surgery helps control pain better and reduces side effects like nausea afterward.
What could go wrong
This is a small, single-center trial with only 60 people, so results may not apply to everyone. Morphine can cause nausea, vomiting, and breathing problems.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2026

Expected to finish

May 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * patients aged 18 to 80 years * classified as American Society of Anesthesiologists (ASA) III * who are scheduled for elective coronary artery bypass grafting. Exclusion Criteria: * Chronic opioid use. * Severe liver or kidney disease. * History of alcohol or substance abuse. * Left ventricular ejection fraction below 40%. * Inability to be weaned from mechanical ventilation within 12 hours after completion of surgery. * Undergoing combined cardiac surgery, including valve procedures. * Requirement for intra-aortic balloon pump (IABP) support. * Surgery performed on a beating heart. * Emergency surgery. * Reoperation due to bleeding or other complications. * Refusal to participate in the study.

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Conditions

The condition(s) this trial relates to.

agnosia coronary artery disorder Pain Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiac surgery patient Pain after surgery Postoperative pain

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Istanbul University -Cerrahpasa Institute of Cardiology

    RECRUITING

    Istanbul, Outside of the US, 34000, Turkey (Türkiye)

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