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Tea tree oil vs. standard mouthwash: a natural remedy for wisdom tooth pain?

NCT ID NCT07180498

Symptom relief Sponsor: Harran University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tests whether tea tree oil mouthwash can reduce pain, swelling, and jaw stiffness after wisdom tooth extraction as well as the standard chlorhexidine mouthwash. Fifty-four adults will use one of the two mouthwashes three times daily for a week after surgery. Researchers will measure pain levels, mouth opening, and gum healing to see if tea tree oil is a good alternative.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Chlorhexidine gluconate 0.12% mouthwash and tea tree oil mouthwash
What this could lead to
If tea tree oil works as well as chlorhexidine, it could offer a natural alternative for managing pain and swelling after wisdom tooth removal.
What could go wrong
This is a small, early-stage trial with only 54 participants, so results may not apply to everyone. Tea tree oil may cause allergic reactions or be less effective than expected.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 54 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2025

Expected to finish

Dec 2025

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Individuals undergoing extraction of Class 2, Class B mandibular third molars impacted in the lower jaw (Pell \& Gregory). * Individuals aged 18-65. * Individuals must be in stable general health (e.g., free of serious cardiovascular or kidney disease). * Individuals willing to use tea tree extract or other treatments. Exclusion Criteria: * Individuals with a known allergy or hypersensitivity to tea tree extract. * Individuals with serious illnesses such as heart failure or kidney disease. Patients with bleeding disorders. * Individuals during pregnancy and breastfeeding. * Individuals taking medications that may interact with tea tree extract (e.g., blood thinners or antihypertensives) * Individuals previously treated for edema. * Individuals with chronic edema.

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative Postoperative Complications Trismus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Periodontal health Postoperative complications Postoperative pain Trismus

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Harran University, Faculty of Dentistry

    RECRUITING

    Sanliurfa, Turkey (Türkiye)

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