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Can a single spinal injection transform Post-Surgery pain relief?

NCT ID NCT07777627

Symptom relief Sponsor: Tanta University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 20, 2026 · Last updated Aug 21, 2026 · Updated 1 time

Summary

This trial tests whether a single injection of morphine or dexmedetomidine into the spinal fluid, given at the end of spine fixation surgery, can provide better pain relief than a placebo. Adults aged 21 to 60 scheduled for elective lumbar spine surgery will be randomly assigned to one of the three groups. The study measures how long patients go before needing extra pain medication, along with heart rate and blood pressure changes over the first 24 hours after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Intrathecal morphine or intrathecal dexmedetomidine, given as a single injection into the spinal fluid at the end of surgery
What this could lead to
If one of these spinal painkillers works better, it could point to a safer, more effective way to manage pain after spine surgery, reducing the need for strong rescue opioids.
What could go wrong
This is a small, early-stage trial, and results may not apply to everyone. Both drugs carry risks like breathing problems, low blood pressure, or nausea, and the placebo comparison helps measure the true effect.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 90 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2026

Expected to finish

Jul 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Aged between 21 and 60 years. * Both sexes. * American Society of Anesthesiologists (ASA) Physical Status I or II. * Scheduled for elective lumbar spine fixation surgery under general anesthesia. Exclusion Criteria: * Patients' refusal. * Decompensated hepatic or renal or cardiac disease. * Coagulation disorder. * Pregnancy and lactation. * Body mass index above 30 kg/m2. * Severe pulmonary disorders. * Patients on opioid, alcohol or allergy to any of the study drugs.

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Intrathecal dexmedetomidine Intrathecal morphine Placebo Postoperative pain Spine fixation surgeries

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Tanta University

    RECRUITING

    Tanta, El-Gharbia, 31527, Egypt

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