POSTOPERATIVE PAIN

This study tested three different materials used to seal root canals to see if one causes less pain after the procedure and leads to better healing of the bone around the tooth root. 72 adults with a tooth infection received a standard root canal treatment and were randomly assig…

This study tested whether adding a supportive mesh patch during surgery to close a temporary intestinal opening (stoma) works better than standard closure. Researchers compared the two methods in 62 patients to see which one better prevents painful hernias, infections, and reduce…

This study compared two different nerve block techniques to manage pain after breast cancer surgery. Researchers tested ultrasound-guided injections in the back to numb nerves before surgery. They measured which method better reduced patients' pain and need for morphine painkille…

This study compared two different nerve block techniques to see which provides better pain relief after abdominal surgery. Researchers tested the Quadratus Lumborum block against the Erector Spinal block in 100 patients undergoing various abdominal procedures. The main goal was t…

This study tested whether a combination of low-dose ketamine and lidocaine works better than the standard drug fentanyl for controlling pain after gynecologic surgery. It involved 70 women having planned surgery under general anesthesia. Researchers measured pain levels and nause…

This study tested a nerve-block injection to help control pain in children after tonsil and adenoid removal surgery. Researchers compared the standard nerve block to one mixed with a drug called dexmedetomidine, hoping it would provide longer-lasting pain relief. The goal was to …

This study tested whether applying a special elastic tape near the surgical cut could help reduce pain for people recovering from heart bypass surgery. Researchers compared real therapeutic tape, a fake placebo tape, and a different supportive treatment in 195 patients. They meas…

This study compared two different ways to place a pain-numbing catheter for patients having outpatient hand surgery. Researchers tested whether a newer 'costoclavicular' approach provided better pain relief 48 hours after surgery than the standard 'paracoracoid' approach. The goa…

This study aimed to find the optimal dose of morphine injected into the spine during a cesarean section to provide the longest-lasting pain relief after surgery. Researchers compared three different doses in 72 healthy women to see which one delayed the need for additional pain m…

This study tested whether giving a combination painkiller (acetaminophen/ibuprofen) right after anesthesia starts is better at reducing opioid painkiller use after surgery than giving it later when the surgeon starts closing. It involved 154 men having robotic prostate removal su…

This study tested whether giving an IV dose of paracetamol (acetaminophen) right before surgery could help reduce the amount of morphine needed for pain afterward. It involved 40 women having a planned abdominal hysterectomy. Researchers compared the morphine use and pain scores …

This study tested whether adding specific pain-blocking injections and a steroid during a planned C-section could reduce severe pain in the first day after delivery. Researchers compared pain reports from 100 women before and after changing the hospital's standard pain protocol. …

This study tested if talking to a mental health professional before kidney donation surgery helps donors feel less anxious and experience less pain. Researchers worked with 123 healthy adults who volunteered to donate a kidney. They measured anxiety, pain levels, and medication u…

This study tested whether guided relaxation exercises could help patients feel better after emergency surgery. Seventy adults who had emergency surgery were split into two groups: one group did structured breathing and muscle relaxation exercises after their operation, while the …

This study tested if a numbing injection near the neck (a nerve block) helps people feel better after thyroid surgery. 160 patients were randomly given either the real numbing medicine or a harmless saltwater placebo before their operation. Researchers then compared how both grou…

This study tested whether a simple nerve block injection could help patients use fewer opioid painkillers after neck disc surgery. Researchers compared 60 patients who received the block to those who did not. The goal was to see if this safe technique could manage pain effectivel…

This study observed 60 patients after minimally invasive chest surgery to see which of two nerve-blocking techniques worked better for pain relief. Doctors compared the Edge Laminar Block (ELB) and the Serratus Posterior Superior Intercostal Plane Block (SPSIPB). The goal was to …

This study compared two different nerve block techniques for controlling pain after thyroid removal surgery. Researchers tested a newer method (erector spinae plane block) against a standard method (cervical plexus block) in 40 patients undergoing thyroid surgery. The goal was to…

This study tested two ways to improve pain control after minimally invasive colon surgery. Researchers compared adding either a low-dose ketamine infusion or a fentanyl skin patch to a standard nerve-block injection. The goal was to see which combination helped patients need less…

This study tested whether a non-opioid pain treatment called HTX 011 could help reduce the need for opioid painkillers after hernia repair surgery. The trial involved 63 adults undergoing hernia surgery who received the experimental treatment as part of their pain management plan…

This study tested two experimental pain medications (HTX-011 and HTX-002) to see if they could effectively reduce pain after tummy tuck surgery. The trial involved 277 adults who underwent this cosmetic procedure. Researchers compared how well these medications worked against eac…

This study tested if a new way of stitching the muscle layer closed after a planned C-section could help reduce pain and allow mothers to walk sooner. Sixty women were randomly assigned to get either the standard stitching method or the new 'guide-suture' technique. Researchers t…

This study tested whether injecting a local anesthetic (ropivacaine) into the chest cavity after lung cancer surgery could reduce severe pain. Researchers enrolled 90 patients who had major chest surgery for cancer. They compared this injection method to standard pain relief to s…

This study aimed to find the best way to position patients when giving a specific type of pain-blocking injection after gallbladder removal surgery. Researchers compared giving the injection while patients were lying on their side, lying on their stomach, or sitting up. They meas…

This study tested whether giving two existing medications, duloxetine and pregabalin, together could better manage pain after liposuction surgery. The goal was to see if this combination could reduce patients' need for strong opioid painkillers and improve their recovery experien…

This study compared two methods for managing pain after major abdominal surgery. Researchers tested whether a newer nerve block technique could provide pain relief similar to a standard spinal morphine injection, but with fewer side effects like nausea or breathing problems. The …

This study looked at whether adding a specific type of pain-blocking injection (called a TAP block) to standard pain medication after a planned C-section could help the surgical wound heal better. Researchers tested this in 105 women by comparing standard care to two different TA…

This study compared two different injection approaches for numbing shoulder pain after arthroscopic surgery. Researchers tested whether injecting pain-blocking medication from the front (anterior) or back (posterior) of the shoulder provided better pain relief with fewer side eff…

This study tested whether letting children play with sand before tonsillectomy surgery could help reduce their anxiety and pain. It involved 68 children aged 7 to 10, who were randomly assigned to either receive sand play therapy or standard care before their operation. Researche…

This study tested an experimental pain medication called HTX-011, given as a nerve block before breast augmentation surgery. Researchers wanted to see if it reduced pain better than standard options and lowered the need for opioid painkillers after the operation. The study involv…

This study looked at whether it's better to give patients their pain medication prescription before or after outpatient surgery. It involved 200 adults having day surgery under general anesthesia. The goal was to see which timing leads to less pain at home after the operation.

This study compared two anesthesia methods for adults having elective nasal surgeries like sinus surgery or septoplasty. Researchers tested whether an opioid-free anesthesia mix (using dexmedetomidine and lignocaine) works as well as or better than standard opioid-based anesthesi…

This study investigated whether reducing noise in the operating room while patients are under anesthesia could help lower their pain levels after major abdominal surgery. Researchers tested this by using noise-isolating headphones on 304 adult patients during their operations. Th…

This study tested whether adding a low-dose ketamine infusion to standard pain medication could help patients after knee replacement surgery. 100 adults were randomly assigned to receive either the standard pain plan or the standard plan plus ketamine. Researchers measured pain l…

This study tested whether giving ketamine during and after breast cancer surgery helps reduce pain and the need for morphine in recovery. It involved 230 women undergoing mastectomy or lumpectomy. Researchers compared pain levels and morphine use in the first 48 hours after surge…

This study tested if showing patients a video before hip replacement surgery could help them move sooner and with less fear after the operation. 96 patients were split into two groups: one watched a video showing safe movement techniques, while the other received standard verbal …

This study compared two types of nerve blocks used to manage pain after keyhole gallbladder removal surgery. Researchers tested whether a newer block (QLB-1) provided better pain relief and reduced the need for strong opioid painkillers compared to a more common block (TAP). The …

This study tested whether a specific nerve block, given in the lower back before surgery, could help control pain afterward. Researchers compared 102 adults having planned spine surgery, with one group getting the new nerve block and the other receiving standard pain medicine. Th…

This study tested whether using a surgical drain after a total knee replacement reduces early post-surgery pain. Researchers compared pain levels in 60 patients over age 60 who had knee replacement, with half receiving a drain and half not. The goal was to see if this common prac…

This study tested whether a specific nerve block could reduce pain after breast cancer surgery that includes reconstruction. It involved 100 patients who were randomly assigned to receive either the nerve block plus standard anesthesia or just standard anesthesia. The main goal w…

This study compared two different nerve block techniques for managing pain after knee replacement surgery. Researchers tested whether a newer method called PASC block works as well as a standard combination of nerve blocks. They measured how much pain medication patients needed i…

This study tested whether a special type of acupuncture using a tiny, dissolvable thread could help reduce pain and improve recovery for people who donated a kidney. Thirty-two kidney donors were randomly assigned to receive either the real thread acupuncture or a fake version th…

This study tested whether a gentle breathing treatment (nebulizer) given at the throat could reduce sore throat pain after thyroid surgery. Researchers compared a mix of two common drugs (budesonide and lidocaine) against a simple saltwater spray in 96 patients. The goal was to f…

This study tested a new type of nerve block injection to see if it could better control pain after a laparoscopic hysterectomy. Fifty patients having this surgery were split into two groups: one received the new nerve block, and the other received standard pain medication. Resear…

This study tested if a special type of electrical nerve stimulation, inspired by wrist-ankle acupuncture theory, could help reduce pain after lung surgery. Researchers compared the real stimulation to a fake (sham) treatment in 156 patients who had a specific type of minimally in…

This study tested if using a brain wave (EEG) monitor during general anesthesia for children's dental procedures could help. Researchers compared two groups of kids aged 4-10: one had standard anesthesia monitoring, and the other had their brain activity monitored to guide anesth…

This study compared two different nerve block techniques for managing pain after shoulder surgery. Researchers tested whether combining two specific nerve blocks would provide similar pain relief while causing less temporary breathing muscle weakness compared to a single, more ex…

This study compared two ways to keep patients asleep and pain-free during weight-loss surgery. One method uses strong painkillers (opioids), while the other tries to avoid them by using a mix of other drugs. Researchers wanted to see if the opioid-free method led to less pain, le…

This study tested whether listening to relaxing music could help women feel less pain and anxiety after having a cesarean section (C-section). 110 first-time mothers were randomly assigned to either listen to classical music for 15 minutes every hour or receive no special interve…

This study tested an experimental pain medication called HTX-011. It was injected directly into the surgical site during knee replacement surgery to see if it could better control pain in the first few days after the operation. Researchers compared it to a standard pain treatment…

This study compared two common methods for delivering pain relief medication after planned cesarean sections. Researchers wanted to know whether giving diclofenac as an injection into the muscle or as a rectal suppository provided better pain control in the first 24 hours after s…

This study tested if a targeted nerve block could better control pain after kidney removal surgery. Researchers compared the nerve block, given during surgery, to the standard approach of giving morphine pills afterward when patients requested them. The goal was to see which meth…

This study looked at whether giving three medications (lidocaine, ketamine, and magnesium) during lung surgery helps reduce pain and the need for strong opioid painkillers afterward. Researchers observed 118 adults who had lung surgery, comparing those who received the three-drug…

This study compared two methods for managing pain after a planned cesarean section (C-section). Researchers tested whether an ultrasound-guided nerve block injection in the back (Quadratus Lumborum block) works as well as adding morphine directly to the spinal anesthesia. The goa…

This study tested whether giving a low dose of magnesium during and after back surgery helps reduce pain in the days following the operation. It involved 60 adults having lumbar spine surgery. The goal was to see if magnesium could lessen the need for strong opioid painkillers an…

This study tested whether a new medicine called HTX-011 could better control pain and reduce the need for opioid painkillers after hernia surgery. Researchers compared HTX-011 against both a placebo (saltwater injection) and a standard pain medicine in 418 patients. The medicine …

This study compared two antiseptic rinses used at the end of a single-visit root canal procedure to see which one better reduces pain in the first two days after treatment. 142 adults with a specific type of tooth infection received either an octenidine or a chlorhexidine rinse d…

This large study tested whether taking ibuprofen for eight days after hip or knee replacement surgery is safe. Nearly 3,000 patients were randomly given either ibuprofen or a placebo pill to see which group had fewer serious complications. The goal was to find the best balance be…

This study tested whether adding a second type of nerve block to a standard pain control method improves recovery after heart surgery. Researchers compared pain levels, opioid medication use, and breathing function in 62 patients who received either one or two types of nerve bloc…

This study tested three experimental gels designed to relieve pain after bunion surgery. The gels were applied directly to the surgical site and contained different combinations of pain-relieving medications. Researchers compared them to see which worked best at reducing pain in …

This study tested whether applying a local anesthetic (lignocaine) directly inside the abdomen during major gynecologic surgery helps reduce pain afterwards. It involved 112 women undergoing open abdominal surgery, comparing the anesthetic to a placebo. The goal was to see if thi…

This study tested whether adding a single high dose of vitamin C to standard pain-blocking injections could help patients recover better after knee replacement surgery. Researchers enrolled 73 patients aged 50-80 to compare pain levels, need for strong painkillers like morphine, …

This study tested whether a mindfulness training session before surgery could help reduce pain after an inguinal hernia repair. Researchers worked with 68 adults to see if learning mindfulness techniques lowered their pain levels, fear of pain, and how much the pain bothered them…

This study compared two different drugs given through an IV during surgery to see which one better manages pain in the first two days after a mastectomy. It involved 40 women undergoing breast cancer surgery. Researchers measured how long before patients needed extra pain medicin…

This study tested whether adding a new type of nerve block, called a PENG block, to standard pain control methods could better manage pain after hip replacement surgery. Researchers enrolled 64 patients to see if this block could reduce the need for strong painkillers like morphi…

This study tested a new pain medicine called HTX-011, which is applied directly to the surgical site during bunion surgery. The goal was to see if it could reduce pain better than a placebo (saltwater injection) or a standard local anesthetic, and if it could help patients use fe…

This study tested whether giving a specific type of numbing injection (a peribulbar block) around the eye before surgery could help control pain and reduce nausea and vomiting after the operation. Researchers compared different numbing medicines in 184 patients having eye surgery…

This study aimed to find the most effective amount of a specific pain-blocking injection for patients recovering from hip replacement surgery. Researchers compared a standard dose to a smaller dose in 50 patients to see which provided better pain relief with fewer side effects. T…

This study tested if using two specific nerve blocks together is better than one for managing pain after breast reduction surgery. Researchers compared three groups of 90 patients: one with no nerve block, one with a single block, and one with a combination of two blocks. The mai…

This study tested an experimental pain medication called HTX-011. It was injected directly into the surgical site during bunion surgery to see if it could reduce pain and the need for opioid painkillers afterward. The trial involved 78 people and measured their pain levels and me…

This study looked at whether applying an ice pack after hemorrhoid surgery helps patients feel better. Researchers compared 429 patients who had surgery, with one group using a 10-minute ice pack application afterward. They wanted to see if the ice helped reduce pain scores and t…

This study tested whether applying a special desensitizing gel under a tooth-colored filling could reduce pain and sensitivity in the week after the procedure. Researchers compared the gel against a standard treatment in 50 adult patients, with each patient receiving both treatme…

This study tested several new long-acting pain relief injections given during hernia surgery. The goal was to see if these new formulations could safely reduce pain for patients in the first 24 hours after their operation. Researchers compared different drug combinations to find …

This study compared two different nerve-blocking techniques to see which one better manages pain and reduces the need for opioid painkillers after a specific type of lung surgery. It involved 76 adults who had a minimally invasive lung lobe removal. Patients were randomly assigne…

This study tested whether adding aromatherapy foot massage to standard care helps people recover after gallbladder removal surgery. Researchers compared 103 patients who received either the massage or usual postoperative care. They measured pain levels, sleep quality, and overall…

This study compared two anesthesia methods for diagnostic hysteroscopy, a common uterine exam, to see which provides better pain relief and patient satisfaction. Researchers randomly assigned 84 women to receive either spinal anesthesia or general anesthesia during their procedur…

This study compared two common pain medications—gabapentin and diclofenac sodium—to see which works better for pain relief after major abdominal surgery. Researchers followed 240 adults who had elective abdominal operations, measuring their pain levels after receiving one of the …

This study tested if a special nerve-block injection given before open-heart bypass surgery could help control pain afterward. 76 patients were randomly assigned to receive either the real nerve-block medicine or a placebo saline injection. Researchers measured patients' pain lev…

This study tested whether giving the common local anesthetic lidocaine through an IV during and after liver surgery helps patients recover better. Researchers compared lidocaine to a saltwater placebo in 124 patients to see if it reduced pain and the need for strong opioid painki…

This study tested if adding a targeted nerve block to standard general anesthesia could improve pain control after major abdominal surgery. Researchers compared pain levels and opioid medication use in 46 adults who received either standard anesthesia or standard anesthesia plus …

This study tested whether simple distraction methods could help adults manage pain after knee replacement surgery. Researchers compared using a virtual reality headset, squeezing a squishy toy, or reading poetry to standard care alone. The main goal was to see if these activities…

This study looked at how well a long-acting pain medication works for people after surgery. Researchers followed 634 patients having planned operations to see if this medication helped control pain better and improved recovery. The goal was to find safer, more effective ways to m…

This study compared two medications given during surgery to help control pain afterwards. It involved 93 adults having bladder tumor removal under spinal anesthesia. Patients received either magnesium sulfate, dexmedetomidine, or a saline solution during their operation. The magn…

This study tested if giving an ibuprofen dose before surgery could help prevent memory and thinking problems that sometimes occur after an operation in older adults. Researchers gave 76 men aged 65-84 either ibuprofen or a placebo (saltwater) before hernia surgery. They then chec…

This study tested if using a sonic tool during a common children's dental procedure (a root canal on a baby tooth) could reduce pain afterward. It also compared a standard pain scale with a new AI phone app designed to read children's facial expressions to measure their discomfor…

This study compared two different nerve-blocking techniques to manage pain after minimally invasive chest surgery. Researchers tested whether injecting numbing medication near specific nerves could reduce pain better than standard pain medication pumps. The goal was to find which…

This study tested whether specific nerve blocks in the chest could improve recovery after heart bypass surgery. Researchers compared two types of nerve blocks against standard pain medication in 243 patients. They measured how long patients needed breathing support, their pain le…

This study tested whether regularly applying ice packs over surgical incisions helps people recover better after major surgery. Researchers enrolled 196 adults having chest, abdominal, or groin surgery. Half were asked to use ice packs every few hours for three days after their o…

This study compared three different pain-blocking techniques for patients having groin hernia repair surgery. Researchers tested whether newer nerve-blocking methods provide better recovery and longer-lasting pain relief compared to standard local numbing. The goal was to help pa…

This study looked at two different nerve-blocking techniques to manage pain after hip replacement surgery in people aged 65 and older. Doctors compared how well each method improved patients' overall recovery quality in the first day after surgery. The research also tracked pain …

This study looked at whether the gender of the anesthesiologist, and whether it matches the patient's gender, affects pain levels and pain medication needs after mastectomy surgery for breast cancer. Researchers observed 120 female patients to see if these factors, along with the…

This study aimed to understand how a common non-opioid painkiller (IV ketorolac) affects blood clotting in women after a cesarean delivery. Researchers enrolled 40 healthy pregnant women scheduled for a C-section to measure changes in platelet function. The goal was to gather saf…

This study aimed to understand how a person's psychology, like their self-esteem and personality traits, might influence the pain they feel after cosmetic breast surgery. Researchers observed 52 patients, measuring their psychological state before surgery and tracking their pain …

This study observed how well standard pain management works for children after elective surgery. Researchers watched 219 children aged 0-18 years and measured their pain levels in the first hour after their operation using age-appropriate pain scales. The goal was to understand t…

This study aimed to understand if patients who feel a sudden tingling or 'electric' sensation when receiving a nerve block for shoulder surgery are more likely to have arm numbness, pain, or weakness afterward. Researchers observed 120 patients having this type of surgery, record…

This study aimed to understand how common long-term pain is after a specific type of chest surgery called a sternotomy, which is often used for heart operations. Researchers followed 200 patients for three months after their surgery to see who developed chronic pain and to look f…

This study aimed to understand how many children in Sweden experience pain after surgery and whether hospitals follow recommended pain management guidelines. Researchers followed 2000 children aged 1-17 who had common surgeries like hernia repair or tonsil removal. The goal was t…