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Could your own blood speed wisdom tooth recovery?

NCT ID NCT07672951

Symptom relief Sponsor: PAEC General Hospital, Islamabad Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 29, 2026 · Last updated Jun 30, 2026 · Updated 1 time

Summary

This trial tests whether placing a clot made from a patient's own blood (platelet-rich fibrin, or PRF) into the socket after wisdom tooth removal can reduce pain, jaw stiffness, and facial swelling. About 134 adults with impacted lower wisdom teeth will receive either PRF or a standard gelatin sponge. Researchers will measure pain, mouth opening, and swelling before surgery and again on days 1 and 7 after the procedure.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Platelet-rich fibrin (PRF)
What this could lead to
If it works, PRF could become a standard, low-cost way to speed recovery and reduce discomfort after wisdom tooth surgery.
What could go wrong
This is a single-center trial with 134 participants, so results may not apply to everyone. PRF may not outperform the standard gelatin sponge, and individual healing varies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

134 people

The number who actually took part.

Started

Dec 2025

Finished

May 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 50 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Patients aged 18 to 50 years Patients with impacted mandibular third molars indicated for surgical extraction Mesioangular or vertical impactions (Winter classification) Class II or Class III impactions, Position B or C (Pell and Gregory classification) Patients who provide written informed consent Exclusion Criteria: Pregnant or lactating females Patients with systemic diseases affecting healing (e.g., uncontrolled diabetes, immunocompromised states) Smokers Patients on medications affecting bone or soft tissue healing Patients with acute infection at the surgical site

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Conditions

The condition(s) this trial relates to.

Edema Pain, Postoperative Trismus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Edema face Impacted mandibular third molar Postoperative pain Trismus

Contacts and locations

Locations

  • PAEC General Hospital, Islamabad

    Islamabad, Federal, 44100, Pakistan

More trials for these conditions

Other studies related to the condition(s) this trial covers.