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Could a natural enzyme mouthwash replace harsh antiseptics after wisdom tooth surgery?

NCT ID NCT07627945

Symptom relief Sponsor: MBD MARKETING SDN. BHD. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jul 02, 2026 · Updated 3 times

Summary

This study tested whether a natural enzyme-containing mouthwash (ORAL7) helps wounds heal better and reduces pain after impacted wisdom tooth removal, compared to a standard antiseptic mouthwash. 58 adults used either the enzyme mouthwash or chlorhexidine mouthwash for one week after surgery. Researchers measured wound healing, pain levels, and mouth opening to see if the natural option works as well or better with fewer side effects.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ORAL7® mouthwash (contains lactoperoxidase, lysozyme, lactoferrin, glucose oxidase)
What this could lead to
If it works, this could offer a gentler alternative to standard antiseptic mouthwash for recovery after wisdom tooth surgery, with fewer side effects like staining or taste changes.
What could go wrong
This is a small, completed trial with only 58 participants. The results may not apply to everyone, and the natural mouthwash may not be more effective than the standard one.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

58 people

The number who actually took part.

Started

Oct 2025

Finished

Jun 2026

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 18 years old and older until required number of samples has been obtained * Impacted mandibular third molar required bone removal * Absence of acute infection in impacted mandibular third molar * Absence of deep caries in the adjacent tooth * No known medical illness * No known drug allergy * Not on medication (prescribed or over the counter) Exclusion Criteria: * 1 Mandibular third molar with soft tissue impaction only * Distoangulated tooth with deep impaction. * Active smoker * Pregnant women * Patients undergoing removal of impacted mandibular third molar due to trauma justification, such as the impacted tooth is at the fractured site. * Mentally challenged patient

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Conditions

The condition(s) this trial relates to.

injury Pain, Postoperative Trismus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Impacted third molar Postoperative pain Trismus Wound healing

Contacts and locations

Locations

  • Oral and Maxillofacial Surgery Unit, School of Dental Sciences, Universiti Sains Malaysia

    Kota Bharu, Kelantan, 16150, Malaysia

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