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Can a sedative outlast a standard painkiller in spinal anesthesia?

NCT ID NCT07770542

Symptom relief Sponsor: Allama Iqbal Teaching Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 18, 2026 · Last updated Aug 19, 2026 · Updated 1 time

Summary

This trial tests whether adding dexmedetomidine to the spinal anesthetic bupivacaine provides longer-lasting pain relief after lower limb orthopedic surgery than adding fentanyl. Sixty adults undergoing leg surgery under spinal anesthesia will be randomly assigned to receive one of the two combinations. After surgery, pain is measured hourly, and the time until a patient first needs rescue pain medication is recorded. The goal is to see if dexmedetomidine extends the duration of effective analgesia compared to fentanyl.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
dexmedetomidine added to bupivacaine for spinal anesthesia
What this could lead to
If dexmedetomidine provides longer-lasting pain relief than fentanyl, it could become a preferred addition to spinal anesthesia for leg surgeries, reducing the need for rescue painkillers.
What could go wrong
This is a small, single-center trial, and results may not apply broadly. Dexmedetomidine can cause side effects like low blood pressure or slow heart rate, and its benefit over fentanyl is not yet proven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

60 people

The number who actually took part.

Started

Aug 2025

Finished

Jan 2026

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * ASA status I and II * Orthopedic leg operations under spinal anesthesia Exclusion Criteria: * Spinal deformity * Coagulopathy (INR \>1.5) * Allergic reaction to local anesthetic * Recent heart attack (≤3-months) * With neurological diseases * Pulmonary diseases * Major liver or kidney disorders and infection of skin at the block site

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Postoperative pain

Contacts and locations

Locations

  • Allama Iqbal Teaching Hospital

    Dera Ghazi Khan, Punjab Province, 32200, Pakistan

More trials for these conditions

Other studies related to the condition(s) this trial covers.