Can a sedative outlast a standard painkiller in spinal anesthesia?

NCT ID NCT07770542

First seen Aug 18, 2026 ยท Last updated Aug 18, 2026

Summary

This trial tests whether adding dexmedetomidine to the spinal anesthetic bupivacaine provides longer-lasting pain relief after lower limb orthopedic surgery than adding fentanyl. Sixty adults undergoing leg surgery under spinal anesthesia will be randomly assigned to receive one of the two combinations. After surgery, pain is measured hourly, and the time until a patient first needs rescue pain medication is recorded. The goal is to see if dexmedetomidine extends the duration of effective analgesia compared to fentanyl.

What this could mean

Our plain-language read of the trial. This is informational only โ€” not medical advice or a prediction.

Active substance
dexmedetomidine added to bupivacaine for spinal anesthesia
What this could lead to
If dexmedetomidine provides longer-lasting pain relief than fentanyl, it could become a preferred addition to spinal anesthesia for leg surgeries, reducing the need for rescue painkillers.
What could go wrong
This is a small, single-center trial, and results may not apply broadly. Dexmedetomidine can cause side effects like low blood pressure or slow heart rate, and its benefit over fentanyl is not yet proven.

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Allama Iqbal Teaching Hospital

    Dera Ghazi Khan, Punjab Province, 32200, Pakistan

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