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Which root canal filler hurts less? study tests three options

NCT ID NCT07339579

Symptom relief Sponsor: Kahramanmaras Sutcu Imam University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at three different root canal sealers to see if any caused less pain or helped teeth heal faster. Seventy-two adults with infected single-rooted teeth received standard root canal treatment with one of the sealers. Pain was checked right after, at 24 hours, and at 72 hours, and healing was checked after six months using X-rays and CT scans.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
root canal sealers (Sealapex, MTA Fillapex, AH Plus)
What this could lead to
If one sealer clearly reduces pain and speeds healing, dentists may choose it to improve patient comfort after root canals.
What could go wrong
This is a small, completed trial with only 72 patients, so results may not apply to everyone. Pain and healing vary widely between individuals.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

72 people

The number who actually took part.

Started

Jan 2024

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18 to 65 years * Patients diagnosed with apical periodontitis * Presence of a single-rooted anterior or premolar tooth with a radiographically visible periapical lesion * Systemically healthy individuals classified as ASA I or ASA II * Ability to understand the study procedures and provide written informed consent Exclusion Criteria: * Teeth with root fractures, external resorption, or open apices * Calcified canals or severely curved root canals (\>30°) * Periodontal pocket depth greater than 3 mm * Pregnancy * Use of antibiotics or analgesics within the previous 7 days * History of previous endodontic treatment or retreatment in the study tooth * Presence of systemic conditions that could affect healing

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Conditions

The condition(s) this trial relates to.

chronic apical periodontitis Pain, Postoperative periapical periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Apical periodontitis Periapical healing Postoperative pain

Contacts and locations

Locations

  • Kahramanmaraş Sutcu İmam University, Faculty of Dentistry

    Kahramanmaraş, onikişubat, 46010, Turkey (Türkiye)

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