New pain combo could cut opioid use after liposuction
NCT ID NCT04862845
First seen Jan 22, 2026 · Last updated Jun 21, 2026 · Updated 18 times
Summary
This study tested whether combining duloxetine and pregabalin before and after liposuction surgery can reduce pain and the need for strong opioid painkillers. 90 adults undergoing liposuction were given either the drug combo, pregabalin alone, or a placebo. The goal was to see if the combo leads to less morphine use and better pain control in the first few days after surgery.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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facility of medicine Cairo university
Cairo, 12613, Egypt
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
duloxetine and pregabalin
What this could lead to
If it works, this drug combination could offer a safer way to manage pain after liposuction, reducing the need for opioids and their side effects.
What could go wrong
This is a small, early-phase trial with only 90 participants, so results may not apply to everyone. The drugs can cause side effects like dizziness or drowsiness.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.