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New drug combo may ease liposuction pain without opioids

NCT ID NCT04862845

Symptom relief Sponsor: Cairo University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed phase 1 trial tested whether combining duloxetine and pregabalin can reduce pain after liposuction surgery. 90 adults were given either the drug combo, pregabalin alone, or a placebo before and after surgery. The goal was to see if the combo lowers the need for morphine and improves recovery. Results could point to a safer, opioid-free pain management option.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
duloxetine and pregabalin
What this could lead to
If it works, this could offer a safer, non-opioid way to manage pain after liposuction surgery.
What could go wrong
This is a small, early-phase trial (phase 1) with only 90 participants. The results may not apply to other surgeries or larger populations, and side effects from the drug combination are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

90 people

The number who actually took part.

Started

Jul 2021

Finished

Jan 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 50 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria: * Patients aged from 18 to40 years. * ASA I-II. * undergoing elective mega -liposuction surgery * BMI from 18 to 50 kg/m2 2\. Exclusion criteria: * Patient refusal * Contraindication or chronic use (consistent use for longer than 3 months) to any of the study drugs ASA III-IV. * Patients aged less than 18 or more than 50. * Body mass index \>50. * Suffered from severe psychiatric disease or drug addiction; * Chronic opioid consumption, * a history of regular sedatives or anticonvulsants intake, serious organ disease or dysfunction * inability to use a PCA device * History of parenteral or oral analgesic intake within the last 48hours.

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Postoperative pain

Contacts and locations

Locations

  • facility of medicine Cairo university

    Cairo, 12613, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.