New drug combo may ease liposuction pain without opioids

NCT ID NCT04862845

Completed Symptom relief Sponsor: Cairo University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed phase 1 trial tested whether combining duloxetine and pregabalin can reduce pain after liposuction surgery. 90 adults were given either the drug combo, pregabalin alone, or a placebo before and after surgery. The goal was to see if the combo lowers the need for morphine and improves recovery. Results could point to a safer, opioid-free pain management option.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: duloxetine and pregabalin
What this could lead to: If it works, this could offer a safer, non-opioid way to manage pain after liposuction surgery.
What could go wrong: This is a small, early-phase trial (phase 1) with only 90 participants. The results may not apply to other surgeries or larger populations, and side effects from the drug combination are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

POSTOPERATIVE PAIN

Contacts and locations

Locations

facility of medicine Cairo university

Cairo, 12613, Egypt

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