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Can a simple nebulizer mist stop Post-Surgery sore throat?

NCT ID NCT07491991

Symptom relief Sponsor: Qianfoshan Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether spraying a mix of budesonide and lidocaine directly on the voice box during thyroid surgery could prevent the common problem of sore throat afterward. 96 adults having thyroid surgery with nerve monitoring were randomly assigned to get either the drug mist or a saltwater mist. The goal was to see if the drug combination reduced pain and other throat symptoms better than plain saline.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
budesonide combined with lidocaine
What this could lead to
If it works, this could provide a simple, non-invasive way to reduce sore throat after thyroid surgery, improving patient comfort and recovery.
What could go wrong
This is a small, single-center Phase 4 trial with only 96 participants. The benefit may be modest or not better than saline, and results may not apply to other surgeries.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

96 people

The number who actually took part.

Started

Mar 2025

Finished

Mar 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Participants have a full understanding of the purpose and significance of this trial, voluntarily participate in the trial, and sign the informed consent form; * Undergoing thyroidectomy with nerve monitoring under general anesthesia (with successful tracheal intubation at the first attempt); * Aged 18 to 60 years, regardless of gender; * Body mass index (BMI) ranging from 18 kg/m² to 30 kg/m²; * Surgical duration of 1 to 4 hours; * American Society of Anesthesiologists (ASA) physical status classification Grade I-II; * No contraindications to the study drugs. Exclusion Criteria: * Current smokers or patients with pre-operative sore throat; * A recent history of upper or lower respiratory tract infection; * Patients who refuse to participate in this study; * Complicated with significant hepatic, renal or other organ dysfunction; * Pregnancy or lactation period; * Patients with a Mallampati classification of Grade Ⅲ or above (Mallampati classification \>2); * Nasogastric tube required during surgery; * Reoperative thyroidectomy; * Pre-operative administration of non-steroidal anti-inflammatory drugs (NSAIDs) or analgesics; * Patients with chronic pharyngitis or gastroesophageal reflux disease (GERD); * More than two attempts of tracheal intubation by an experienced anesthesiologist; * Patients with a known allergy to the study drugs.

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Nebulization Postoperative pain Thyroid surgery

Contacts and locations

Locations

  • Qianfoshan Hospital, The First Hospital affiliated of Shandong First Medical University

    Jinan, Shandong, 250000, China

More trials for these conditions

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